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相关论文: Exploring Large Protein Language Models in Constra…

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Contrastive Language-Image Pretraining (CLIP) models are able to capture the semantic relationship of images and texts and have enabled a wide range of applications, from image retrieval to classification. These models are trained with…

计算机视觉与模式识别 · 计算机科学 2023-11-09 Calvin Metzger

Fine-grained vision-language understanding requires precise alignment between visual content and linguistic descriptions, a capability that remains limited in current models, particularly in non-English settings. While models like CLIP…

计算机视觉与模式识别 · 计算机科学 2026-05-26 Chunyu Xie , Bin Wang , Fanjing Kong , Jincheng Li , Dawei Liang , Ji Ao , Dawei Leng , Yuhui Yin

The advancement of large language models (LLMs) has led to a greater challenge of having a rigorous and systematic evaluation of complex tasks performed, especially in enterprise applications. Therefore, LLMs need to be able to benchmark…

计算与语言 · 计算机科学 2024-10-18 Bing Zhang , Mikio Takeuchi , Ryo Kawahara , Shubhi Asthana , Md. Maruf Hossain , Guang-Jie Ren , Kate Soule , Yada Zhu

Deciphering the function of unseen protein sequences is a fundamental challenge with broad scientific impact, yet most existing methods depend on task-specific adapters or large-scale supervised fine-tuning. We introduce the…

机器学习 · 计算机科学 2025-10-14 Xinhui Chen , Zuchao Li , Mengqi Gao , Yufeng Zhang , Chak Tou Leong , Haoyang Li , Jiaqi Chen

Proteins, essential to biological systems, perform functions intricately linked to their three-dimensional structures. Understanding the relationship between protein structures and their amino acid sequences remains a core challenge in…

定量方法 · 定量生物学 2024-11-04 Liang He , Peiran Jin , Yaosen Min , Shufang Xie , Lijun Wu , Tao Qin , Xiaozhuan Liang , Kaiyuan Gao , Yuliang Jiang , Tie-Yan Liu

Reasoning has emerged as the next major frontier for language models (LMs), with rapid advances from both academic and industrial labs. However, this progress often outpaces methodological rigor, with many evaluations relying on…

Harnessing the power of human-annotated data through Supervised Fine-Tuning (SFT) is pivotal for advancing Large Language Models (LLMs). In this paper, we delve into the prospect of growing a strong LLM out of a weak one without the need…

机器学习 · 计算机科学 2024-06-18 Zixiang Chen , Yihe Deng , Huizhuo Yuan , Kaixuan Ji , Quanquan Gu

Click-through rate (CTR) prediction plays as a core function module in various personalized online services. The traditional ID-based models for CTR prediction take as inputs the one-hot encoded ID features of tabular modality, which…

信息检索 · 计算机科学 2024-10-31 Hangyu Wang , Jianghao Lin , Xiangyang Li , Bo Chen , Chenxu Zhu , Ruiming Tang , Weinan Zhang , Yong Yu

Deep neural-network-based language models (LMs) are increasingly applied to large-scale protein sequence data to predict protein function. However, being largely black-box models and thus challenging to interpret, current protein LM…

Learning effective protein representations is critical in a variety of tasks in biology such as predicting protein functions. Recent sequence representation learning methods based on Protein Language Models (PLMs) excel in sequence-based…

定量方法 · 定量生物学 2023-10-19 Zuobai Zhang , Chuanrui Wang , Minghao Xu , Vijil Chenthamarakshan , Aurélie Lozano , Payel Das , Jian Tang

Protein Language Models (PLMs), pre-trained on extensive evolutionary data from natural proteins, have emerged as indispensable tools for protein design. While powerful, PLMs often struggle to produce proteins with precisely specified…

生物大分子 · 定量生物学 2025-09-15 Long-Kai Huang , Rongyi Zhu , Bing He , Jianhua Yao

Protein modeling is an increasingly popular area of machine learning research. Semi-supervised learning has emerged as an important paradigm in protein modeling due to the high cost of acquiring supervised protein labels, but the current…

机器学习 · 计算机科学 2019-06-20 Roshan Rao , Nicholas Bhattacharya , Neil Thomas , Yan Duan , Xi Chen , John Canny , Pieter Abbeel , Yun S. Song

CLIP models perform remarkably well on zero-shot classification and retrieval tasks. But recent studies have shown that learnt representations in CLIP are not well suited for dense prediction tasks like object detection, semantic…

计算机视觉与模式识别 · 计算机科学 2024-05-16 Pavan Kumar Anasosalu Vasu , Hadi Pouransari , Fartash Faghri , Oncel Tuzel

The objective in this paper is to improve the performance of text-to-image retrieval. To this end, we introduce a new framework that can boost the performance of large-scale pre-trained vision-language models, so that they can be used for…

计算机视觉与模式识别 · 计算机科学 2025-10-21 Guanqi Zhan , Yuanpei Liu , Kai Han , Weidi Xie , Andrew Zisserman

Unlocking the potential of Large Language Models (LLMs) in data classification represents a promising frontier in natural language processing. In this work, we evaluate the performance of different LLMs in comparison with state-of-the-art…

计算与语言 · 计算机科学 2025-01-16 Arina Kostina , Marios D. Dikaiakos , Dimosthenis Stefanidis , George Pallis

Fine-tuning large language models (LLMs) with limited data poses a practical challenge in low-resource languages, specialized domains, and constrained deployment settings. While pre-trained LLMs provide strong foundations, effective…

计算与语言 · 计算机科学 2025-10-29 Marton Szep , Daniel Rueckert , Rüdiger von Eisenhart-Rothe , Florian Hinterwimmer

Reasoning has substantially improved the performance of large language models (LLMs) on complicated tasks. Central to the current reasoning studies, Process Reward Models (PRMs) offer a fine-grained evaluation of intermediate reasoning…

机器学习 · 计算机科学 2025-11-05 Qi Cao , Ruiyi Wang , Ruiyi Zhang , Sai Ashish Somayajula , Pengtao Xie

Despite the impressive performance of large language models (LLMs), they often lag behind specialized models in various tasks. LLMs only use a fraction of the existing training data for in-context learning, while task-specific models…

计算与语言 · 计算机科学 2024-02-02 Giorgos Vernikos , Arthur Bražinskas , Jakub Adamek , Jonathan Mallinson , Aliaksei Severyn , Eric Malmi

Contrastive language-image pre-training (CLIP) models have demonstrated considerable success across various vision-language tasks, such as text-to-image retrieval, where the model is required to effectively process natural language input to…

计算机视觉与模式识别 · 计算机科学 2024-02-26 Hyunjae Kim , Seunghyun Yoon , Trung Bui , Handong Zhao , Quan Tran , Franck Dernoncourt , Jaewoo Kang

Protein language models (pLMs), pre-trained via causal language modeling on protein sequences, have been a promising tool for protein sequence design. In real-world protein engineering, there are many cases where the amino acids in the…

机器学习 · 计算机科学 2023-03-30 Youhan Lee , Hasun Yu