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Digital PCR (dPCR) has revolutionized nucleic acid diagnostics by enabling absolute quantification of rare mutations and target sequences. However, current detection methodologies face challenges, as flow cytometers are costly and complex,…

Absolute quantification of biological samples entails determining expression levels in precise numerical copies, offering enhanced accuracy and superior performance for rare templates. However, existing methodologies suffer from significant…

Deep learning models have gained increasing adoption in medical image analysis. However, these models often produce overconfident predictions, which can compromise clinical accuracy and reliability. Bridging the gap between high-performance…

图像与视频处理 · 电气工程与系统科学 2026-03-24 Jutika Borah , Hidam Kumarjit Singh

Prostate cancer being one of the frequently diagnosed malignancy in men, the rising demand for biopsies places a severe workload on pathologists. The grading procedure is tedious and subjective, motivating the development of automated…

计算机视觉与模式识别 · 计算机科学 2026-03-06 Riddhasree Bhattacharyya , Pallabi Dutta , Sushmita Mitra

Digital mammography is essential to breast cancer detection, and deep learning offers promising tools for faster and more accurate mammogram analysis. In radiology and other high-stakes environments, uninterpretable ("black box") deep…

计算机视觉与模式识别 · 计算机科学 2024-06-11 Julia Yang , Alina Jade Barnett , Jon Donnelly , Satvik Kishore , Jerry Fang , Fides Regina Schwartz , Chaofan Chen , Joseph Y. Lo , Cynthia Rudin

MLLMs (Multimodal Large Language Models) have showcased remarkable capabilities, but their performance in high-stakes, domain-specific scenarios like surgical settings, remains largely under-explored. To address this gap, we develop…

计算机视觉与模式识别 · 计算机科学 2025-10-03 Gui Wang , Yang Wennuo , Xusen Ma , Zehao Zhong , Zhuoru Wu , Ende Wu , Rong Qu , Wooi Ping Cheah , Jianfeng Ren , Linlin Shen

Recent advances in AIGC have exacerbated the misuse of malicious deepfake content, making the development of reliable deepfake detection methods an essential means to address this challenge. Although existing deepfake detection models…

计算机视觉与模式识别 · 计算机科学 2025-10-31 Changtao Miao , Yi Zhang , Weize Gao , Zhiya Tan , Weiwei Feng , Man Luo , Jianshu Li , Ajian Liu , Yunfeng Diao , Qi Chu , Tao Gong , Zhe Li , Weibin Yao , Joey Tianyi Zhou

Deep learning methods, in particular convolutional neural networks, have emerged as a powerful tool in medical image computing tasks. While these complex models provide excellent performance, their black-box nature may hinder real-world…

图像与视频处理 · 电气工程与系统科学 2022-10-18 Yuzhe Lu , Adam Perer

Computational imaging is crucial in many disciplines from autonomous driving to life sciences. However, traditional model-driven and iterative methods consume large computational power and lack scalability for imaging. Deep learning (DL) is…

图像与视频处理 · 电气工程与系统科学 2024-08-26 Weiru Fan , Xiaobin Tang , Yiyi Liao , Da-Wei Wang

High-throughput technologies such as next generation sequencing allow biologists to observe cell function with unprecedented resolution, but the resulting datasets are too large and complicated for humans to understand without the aid of…

应用统计 · 统计学 2021-10-08 David S. Watson

The field of medical diagnosis has undergone a significant transformation with the advent of large language models (LLMs), yet the challenges of interpretability within these models remain largely unaddressed. This study introduces…

计算与语言 · 计算机科学 2024-09-17 Junying Chen , Chi Gui , Anningzhe Gao , Ke Ji , Xidong Wang , Xiang Wan , Benyou Wang

Deep neural networks (DNNs) have achieved remarkable success in radio frequency (RF) fingerprinting for wireless device authentication. However, their practical deployment faces two major limitations: domain shift, where models trained in…

密码学与安全 · 计算机科学 2026-02-04 Tianya Zhao , Junqing Zhang , Haowen Xu , Xiaoyan Sun , Jun Dai , Xuyu Wang

Diagnosing rare diseases presents a common challenge in clinical practice, necessitating the expertise of specialists for accurate identification. The advent of machine learning offers a promising solution, while the development of such…

Deep learning (DL) models for image-based malware detection have exhibited their capability in producing high prediction accuracy. But model interpretability is posing challenges to their widespread application in security and…

机器学习 · 计算机科学 2021-01-14 Yuzhou Lin , Xiaolin Chang

Medical image classification is a critical problem for healthcare, with the potential to alleviate the workload of doctors and facilitate diagnoses of patients. However, two challenges arise when deploying deep learning models to real-world…

计算机视觉与模式识别 · 计算机科学 2023-10-06 An Yan , Yu Wang , Yiwu Zhong , Zexue He , Petros Karypis , Zihan Wang , Chengyu Dong , Amilcare Gentili , Chun-Nan Hsu , Jingbo Shang , Julian McAuley

In point-based sensing systems such as coordinate measuring machines (CMM) and laser ultrasonics where complete sensing is impractical due to the high sensing time and cost, adaptive sensing through a systematic exploration is vital for…

机器学习 · 统计学 2019-10-08 Hao Yan , Kamran Paynabar , Jianjun Shi

In recent years, molecular graph representation learning (GRL) has drawn much more attention in molecular property prediction (MPP) problems. The existing graph methods have demonstrated that 3D geometric information is significant for…

机器学习 · 计算机科学 2022-12-01 Hao Zhang , Nan Zhang , Ruixin Zhang , Lei Shen , Yingyi Zhang , Meng Liu

The precise quantification of nucleic acids is pivotal in molecular biology, underscored by the rising prominence of nucleic acid amplification tests (NAAT) in diagnosing infectious diseases and conducting genomic studies. This review…

定量方法 · 定量生物学 2024-08-01 Yuanyuan Wei , Xianxian Liu , Changran Xu , Guoxun Zhang , Wu Yuan , Ho-Pui Ho , Mingkun Xu

Deep neural network (DNN) models for retinopathy have estimated predictive accuracies in the mid-to-high 90%. However, the following aspects remain unaddressed: State-of-the-art models are complex and require substantial computational…

Dermatological diseases are among the most common disorders worldwide. This paper presents the first study of the interpretability and imbalanced semi-supervised learning of the multiclass intelligent skin diagnosis framework (ISDL) using…

计算机视觉与模式识别 · 计算机科学 2024-06-11 Futian Weng , Yuanting Ma , Jinghan Sun , Shijun Shan , Qiyuan Li , Jianping Zhu , Yang Wang , Yan Xu
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