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In observational studies, the causal effect of a treatment may be confounded with variables that are related to both the treatment and the outcome of interest. In order to identify a causal effect, such studies often rely on the…

统计方法学 · 统计学 2017-10-17 Emma Persson , Jenny Häggström , Ingeborg Waernbaum , Xavier de Luna

Nonparametric covariate adjustment is considered for log-rank type tests of treatment effect with right-censored time-to-event data from clinical trials applying covariate-adaptive randomization. Our proposed covariate-adjusted log-rank…

统计方法学 · 统计学 2023-01-23 Ting Ye , Jun Shao , Yanyao Yi

Randomized Controlled Trials (RCTs) may suffer from limited scope. In particular, samples may be unrepresentative: some RCTs over- or under- sample individuals with certain characteristics compared to the target population, for which one…

统计方法学 · 统计学 2024-03-15 Bénédicte Colnet , Julie Josse , Gaël Varoquaux , Erwan Scornet

Feature selection is an important but challenging task in causal inference for obtaining unbiased estimates of causal quantities. Properly selected features in causal inference not only significantly reduce the time required to implement a…

统计方法学 · 统计学 2025-02-04 Tianyu Yang , Md. Noor-E-Alam

In high-dimensions, many variable selection methods, such as the lasso, are often limited by excessive variability and rank deficiency of the sample covariance matrix. Covariance sparsity is a natural phenomenon in high-dimensional…

统计方法学 · 统计学 2010-06-08 X. Jessie Jeng And Z. John Daye

In recent years, data selection has emerged as a core issue for large-scale visual-language model pretraining, especially on noisy web-curated datasets. One widely adopted strategy assigns quality scores such as CLIP similarity for each…

机器学习 · 计算机科学 2024-02-06 Yiping Wang , Yifang Chen , Wendan Yan , Kevin Jamieson , Simon Shaolei Du

The goals in clinical and cohort studies often include evaluation of the association of a time-dependent binary treatment or exposure with a survival outcome. Recently, several impactful studies targeted the association between…

应用统计 · 统计学 2019-01-24 Daniel Nevo , Tsuyoshi Hamada , Shuji Ogino , Molin Wang

Selection of covariates is crucial in the estimation of average treatment effects given observational data with high or even ultra-high dimensional pretreatment variables. Existing methods for this problem typically assume sparse linear…

统计方法学 · 统计学 2023-03-20 Juan Chen , Yingchun Zhou

Modern randomization methods in clinical trials are invariably adaptive, meaning that the assignment of the next subject to a treatment group uses the accumulated information in the trial. Some of the recent adaptive randomization methods…

统计方法学 · 统计学 2024-02-12 Alan R. Vazquez , Weng Kee Wong

Quantile treatment effects (QTEs) can characterize the potentially heterogeneous causal effect of a treatment on different points of the entire outcome distribution. Propensity score (PS) methods are commonly employed for estimating QTEs in…

统计方法学 · 统计学 2023-08-15 Yahang Liu , Kecheng Wei , Chen Huang , Yongfu Yu , Guoyou Qin

A typical assumption in supervised machine learning is that the train (source) and test (target) datasets follow completely the same distribution. This assumption is, however, often violated in uncertain real-world applications, which…

机器学习 · 计算机科学 2021-08-17 Masahiro Nomura , Yuta Saito

Two commonly used methods for improving precision and power in clinical trials are stratified randomization and covariate adjustment. However, many trials do not fully capitalize on the combined precision gains from these two methods, which…

统计方法学 · 统计学 2020-09-04 Bingkai Wang , Ryoko Susukida , Ramin Mojtabai , Masoumeh Amin-Esmaeili , Michael Rosenblum

Reliable uncertainty quantification is essential in survival prediction, particularly in clinical settings where erroneous decisions carry high risk. Conformal prediction has attracted substantial attention as it offers a model-agnostic…

统计方法学 · 统计学 2025-12-04 Jaeyoung Shin , Chi Hyun Lee , Sangwook Kang

An individualized treatment rule (ITR) is a decision rule that aims to improve individual patients health outcomes by recommending optimal treatments according to patients specific information. In observational studies, collected data may…

统计方法学 · 统计学 2023-10-03 Zeyu Bian , Erica EM Moodie , Susan M Shortreed , Sylvie D Lambert , Sahir Bhatnagar

The first step towards investigating the effectiveness of a treatment via a randomized trial is to split the population into control and treatment groups then compare the average response of the treatment group receiving the treatment to…

计量经济学 · 经济学 2022-08-30 Hossein Babaei , Sina Alemohammad , Richard Baraniuk

Companies offering web services routinely run randomized online experiments to estimate the causal impact associated with the adoption of new features and policies on key performance metrics of interest. These experiments are used to…

统计方法学 · 统计学 2023-07-13 Lorenzo Masoero , Doug Hains , James McQueen

With a large number of baseline covariates, we propose a new semi-parametric modeling strategy for heterogeneous treatment effect estimation and individualized treatment selection, which are two major goals in personalized medicine. We…

统计方法学 · 统计学 2021-08-12 Wenchuan Guo , Xiao-hua Zhou , Shujie Ma

We study optimization for data-driven decision-making when we have observations of the uncertain parameters within the optimization model together with concurrent observations of covariates. Given a new covariate observation, the goal is to…

最优化与控制 · 数学 2022-07-28 Rohit Kannan , Güzin Bayraksan , James R. Luedtke

Sliced inverse regression is a popular tool for sufficient dimension reduction, which replaces covariates with a minimal set of their linear combinations without loss of information on the conditional distribution of the response given the…

机器学习 · 统计学 2018-09-18 Kean Ming Tan , Zhaoran Wang , Tong Zhang , Han Liu , R. Dennis Cook

Healthcare data often come from multiple sites in which the correlations between confounding variables can vary widely. If deep learning models exploit these unstable correlations, they might fail catastrophically in unseen sites. Although…

机器学习 · 计算机科学 2023-10-25 Minh Nguyen , Alan Q. Wang , Heejong Kim , Mert R. Sabuncu