相关论文: Scaling Up ESM2 Architectures for Long Protein Seq…

Inferring the structural properties of a protein from its amino acid sequence is a challenging yet important problem in biology. Structures are not known for the vast majority of protein sequences, but structure is critical for…

Proteins adopt multiple structural conformations to perform their diverse biological functions, and understanding these conformations is crucial for advancing drug discovery. Traditional physics-based simulation methods often struggle with…

Effective representations of protein sequences are widely recognized as a cornerstone of machine learning-based protein design. Yet, protein bioengineering poses unique challenges for sequence representation, as experimental datasets…

Understanding biological processes, drug development, and biotechnological advancements requires a detailed analysis of protein structures and functions, a task that is inherently complex and time-consuming in traditional protein research.…

Protein-nucleic acid interactions play a very important role in a variety of biological activities. Accurate identification of nucleic acid-binding residues is a critical step in understanding the interaction mechanisms. Although many…

Proteins are essential macromolecules defined by their amino acid sequences, which determine their three-dimensional structures and, consequently, their functions in all living organisms. Therefore, generative protein modeling necessitates…

Large-scale Protein Language Models (PLMs) have improved performance in protein prediction tasks, ranging from 3D structure prediction to various function predictions. In particular, AlphaFold, a ground-breaking AI system, could potentially…

Protein language models (PLMs) have demonstrated remarkable capabilities in learning relationships between protein sequences and functions. However, finetuning these large models requires substantial computational resources, often with…

Computational biology and bioinformatics provide vast data gold-mines from protein sequences, ideal for Language Models taken from NLP. These LMs reach for new prediction frontiers at low inference costs. Here, we trained two…

Increasing the number of parameters in large language models (LLMs) usually improves performance in downstream tasks but raises compute and memory costs, making deployment difficult in resource-limited settings. Quantization techniques,…

While protein language models (PLMs) are one of the most promising avenues of research for future de novo protein design, the way in which they transform sequences to hidden representations, as well as the information encoded in such…

Large language models (LLMs) have transformed artificial intelligence, yet classical architectures impose a fundamental constraint: every trainable parameter demands classical memory that scales unfavourably with model size. Quantum…

Large Language Models (LLMs) have been extensively researched and used in both academia and industry since the rise in popularity of the Transformer model, which demonstrates excellent performance in AI. However, the computational demands…

Tokenization is a crucial step in processing protein sequences for machine learning models, as proteins are complex sequences of amino acids that require meaningful segmentation to capture their functional and structural properties.…

Despite the growing prevalence of large language model (LLM) architectures, a crucial concern persists regarding their energy and power consumption, which still lags far behind the remarkable energy efficiency of the human brain. Recent…

Supervised fine-tuning (SFT) is a standard approach for adapting large language models to specialized domains, yet its application to protein sequence modeling and protein language models (PLMs) remains ad hoc. This is in part because…

Entity Matching (EM) involves identifying different data representations referring to the same entity from multiple data sources and is typically formulated as a binary classification problem. It is a challenging problem in data integration…

Large Language Models (LLMs) have been emerging as prominent AI models for solving many natural language tasks due to their high performance (e.g., accuracy) and capabilities in generating high-quality responses to the given inputs.…

Pre-trained models have been successful in many protein engineering tasks. Most notably, sequence-based models have achieved state-of-the-art performance on protein fitness prediction while structure-based models have been used…

The structure and function of a protein are determined by its amino acid sequence. While random mutations change a protein's sequence, evolutionary forces shape its structural fold and biological activity. Studies have shown that neutral…