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Limited availability of labeled physiological data often prohibits the use of powerful supervised deep learning models in the biomedical machine intelligence domain. We approach this problem and propose a novel encoding framework that…

For protein sequence datasets, unlabeled data has greatly outpaced labeled data due to the high cost of wet-lab characterization. Recent deep-learning approaches to protein prediction have shown that pre-training on unlabeled data can yield…

机器学习 · 计算机科学 2020-12-02 Pascal Sturmfels , Jesse Vig , Ali Madani , Nazneen Fatema Rajani

Gene expression levels, hormone secretion, and internal body temperature each oscillate over an approximately 24-hour cycle, or display circadian rhythms. Many circadian biology studies have investigated how these rhythms vary across…

Metabolomic data can potentially enable accurate, non-invasive and low-cost prediction of coronary artery disease. Regression-based analytical approaches however might fail to fully account for interactions between metabolites, rely on a…

Pulse timing is an important topic in nuclear instrumentation, with far-reaching applications from high energy physics to radiation imaging. While high-speed analog-to-digital converters become more and more developed and accessible, their…

仪器与探测器 · 物理学 2023-09-28 Pengcheng Ai , Le Xiao , Zhi Deng , Yi Wang , Xiangming Sun , Guangming Huang , Dong Wang , Yulei Li , Xinchi Ran

The gene networks that comprise the circadian clock modulate biological function across a range of scales, from gene expression to performance and adaptive behaviour. The clock functions by generating endogenous rhythms that can be…

分子网络 · 定量生物学 2012-10-25 Ozgur Akman , Steven Watterson , Andrew Parton , Nigel Binns , Andrew Millar , Peter Ghazal

This paper presents an approach to trajectory-centric learning control based on contraction metrics and disturbance estimation for nonlinear systems subject to matched uncertainties. The approach uses deep neural networks to learn uncertain…

系统与控制 · 电气工程与系统科学 2024-07-25 Pan Zhao , Ziyao Guo , Yikun Cheng , Aditya Gahlawat , Hyungsoo Kang , Naira Hovakimyan

Facial feature tracking is essential in imaging ballistocardiography for accurate heart rate estimation and enables motor degradation quantification in Parkinson's disease through skin feature tracking. While deep convolutional neural…

计算机视觉与模式识别 · 计算机科学 2024-05-09 Jose Chang , Torbjörn E. M. Nordling

Temporal anomaly detection looks for irregularities over space-time. Unsupervised temporal models employed thus far typically work on sequences of feature vectors, and much less on temporal multiway data. We focus our investigation on…

机器学习 · 计算机科学 2020-09-22 Duc Nguyen , Phuoc Nguyen , Kien Do , Santu Rana , Sunil Gupta , Truyen Tran

Motivation: Drug discovery demands rapid quantification of compound-protein interaction (CPI). However, there is a lack of methods that can predict compound-protein affinity from sequences alone with high applicability, accuracy, and…

生物大分子 · 定量生物学 2020-12-17 Mostafa Karimi , Di Wu , Zhangyang Wang , Yang Shen

Accurate predictions of peptide retention times (RT) in liquid chromatography have many applications in mass spectrometry-based proteomics. Herein, we present DeepRT, a deep learning based software for peptide retention time prediction.…

定量方法 · 定量生物学 2017-05-17 Chunwei Ma , Zhiyong Zhu , Jun Ye , Jiarui Yang , Jianguo Pei , Shaohang Xu , Ruo Zhou , Chang Yu , Fan Mo , Bo Wen , Siqi Liu

Accurate estimation of the human circadian phase plays an important role in personalized health monitoring, but most existing wearable-based approaches operate retrospectively and require full circadian cycle recordings, leading to high…

信号处理 · 电气工程与系统科学 2026-05-05 Mengzhu Xu , Nemanja Cabrilo , Merel van Gilst , Jean-Paul Linnartz

Subtle periodic signals, such as blood volume pulse and respiration, can be extracted from RGB video, enabling noncontact health monitoring at low cost. Advancements in remote pulse estimation -- or remote photoplethysmography (rPPG) -- are…

计算机视觉与模式识别 · 计算机科学 2024-04-23 Jeremy Speth , Nathan Vance , Patrick Flynn , Adam Czajka

We introduce a new predictive mechanism that operates in the presence of hidden confounding across distributionally diverse data sources while ensuring consistent estimation of causal parameters-despite their recognized suboptimality for…

统计理论 · 数学 2025-04-01 Carlos García Meixide , David Ríos Insua

We propose a systematic methodology to identify the topological phase transition through a self-supervised machine learning model, which is trained to correlate system parameters to the non-local observables in time-of-flight experiments of…

量子气体 · 物理学 2021-09-01 Chi-Ting Ho , Daw-Wei Wang

Machine learning techniques have been shown to be effective to recognize different phases of matter and produce phase diagrams in the parameter space interested, while they usually require prior labeled data to perform well. Here, we…

Neural population activity relating to behaviour is assumed to be inherently low-dimensional despite the observed high dimensionality of data recorded using multi-electrode arrays. Therefore, predicting behaviour from neural population…

神经元与认知 · 定量生物学 2022-02-17 Justin Jude , Matthew G Perich , Lee E Miller , Matthias H Hennig

Biological data are extremely diverse, complex but also quite sparse. The recent developments in deep learning methods are offering new possibilities for the analysis of complex data. However, it is easy to be get a deep learning model that…

机器学习 · 计算机科学 2019-01-21 Florian Richoux , Charlène Servantie , Cynthia Borès , Stéphane Téletchéa

Identifying phase transitions is one of the key challenges in quantum many-body physics. Recently, machine learning methods have been shown to be an alternative way of localising phase boundaries also from noisy and imperfect data and…

Deep regression is an important problem with numerous applications. These range from computer vision tasks such as age estimation from photographs, to medical tasks such as ejection fraction estimation from echocardiograms for disease…

计算机视觉与模式识别 · 计算机科学 2023-02-16 Weihang Dai , Xiaomeng Li , Kwang-Ting Cheng