相关论文: PROTECT: Protein circadian time prediction using u…
Modeling biological rhythms helps understand the complex principles behind the physical and psychological abnormalities of human bodies, to plan life schedules, and avoid persisting fatigue and mood and sleep alterations due to the…
Epileptic biomarkers play a crucial role in identifying the origin of seizures, an essential aspect of pre-surgical planning for epilepsy treatment. These biomarkers can vary significantly over time. By studying these temporal fluctuations,…
Machine learning and in particular deep learning algorithms are the emerging approaches to data analysis. These techniques have transformed traditional data mining-based analysis radically into a learning-based model in which existing data…
Adapting to regularities of the environment is critical for biological organisms to anticipate events and plan. A prominent example is the circadian rhythm corresponding to the internalization by organisms of the $24$-hour period of the…
An important occurrence in many cellular contexts is the crossing of a prescribed threshold by a regulatory protein. The timing of such events is stochastic as a consequence of the innate randomness in gene expression. A question of…
Rhythmic data are ubiquitous in the life sciences. Biologists need reliable statistical tests to identify whether a particular experimental treatment has caused a significant change in a rhythmic signal. When these signals display…
Objective. We identify two linked problems related to estimating the phase of the alpha rhythm when the signal after a specific event is unknown (real-time case), or corrupted (offline analysis). We propose methods to estimate the phase…
Chronobiological rhythms, such as the circadian rhythm, have long been linked to neurological disorders, but it is currently unknown how pathological processes affect the expression of biological rhythms in the brain. Here, we use the…
When faced with distribution shift at test time, deep neural networks often make inaccurate predictions with unreliable uncertainty estimates. While improving the robustness of neural networks is one promising approach to mitigate this…
The classification of electrocardiogram (ECG) plays a crucial role in the development of an automatic cardiovascular diagnostic system. However, considerable variances in ECG signals between individuals is a significant challenge. Changes…
The mammalian circadian system comprises a network of cell-autonomous oscillators, spanning from the central clock in the brain to peripheral clocks in other organs. These clocks are tightly coordinated to orchestrate rhythmic physiological…
Deep learning models have shown great promise in various healthcare monitoring applications. However, most healthcare datasets with high-quality (gold-standard) labels are small-scale, as directly collecting ground truth is often costly and…
Quantitatively predicting phenotype variables by the expression changes in a set of candidate genes is of great interest in molecular biology but it is also a challenging task for several reasons. First, the collected biological…
In this work, we investigate unsupervised representation learning on medical time series, which bears the promise of leveraging copious amounts of existing unlabeled data in order to eventually assist clinical decision making. By evaluating…
The prediction of intrinsic disorder regions has significant implications for understanding protein functions and dynamics. It can help to discover novel protein-protein interactions essential for designing new drugs and enzymes. Recently,…
Epilepsy is a common, chronic neurological disorder characterized by recurrent seizures caused by sudden bursts of abnormal electrical activity in the brain. Seizures can often be unpredictable, leading to uncertainty and anxiety for people…
As clinical data are becoming increasingly available, machine learning methods have been employed to extract knowledge from them and predict clinical events. While promising, approaches suffer from at least two main issues: low availability…
Survival time prediction from medical images is important for treatment planning, where accurate estimations can improve healthcare quality. One issue affecting the training of survival models is censored data. Most of the current survival…
Many biological processes display oscillatory behavior based on an approximately 24 hour internal timing system specific to each individual. One process of particular interest is gene expression, for which several circadian transcriptomic…
The human ability to track musical downbeats is robust to changes in tempo, and it extends to tempi never previously encountered. We propose a deterministic time-warping operation that enables this skill in a convolutional neural network…