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Radiography Report Generation (RRG) has gained significant attention in medical image analysis as a promising tool for alleviating the growing workload of radiologists. However, despite numerous advancements, existing methods have yet to…

计算机视觉与模式识别 · 计算机科学 2025-09-29 Valentin Samokhin , Boris Shirokikh , Mikhail Goncharov , Dmitriy Umerenkov , Maksim Bobrin , Ivan Oseledets , Dmitry Dylov , Mikhail Belyaev

We present a multi-objective binder design paradigm based on instruction fine-tuning and direct preference optimization (DPO) of autoregressive protein language models (pLMs). Multiple design objectives are encoded in the language model…

生物物理 · 物理学 2024-03-08 Pouria Mistani , Venkatesh Mysore

With the boom of e-commerce and web applications, recommender systems have become an important part of our daily lives, providing personalized recommendations based on the user's preferences. Although deep neural networks (DNNs) have made…

人工智能 · 计算机科学 2024-03-13 Xiaonan Xu , Yichao Wu , Penghao Liang , Yuhang He , Han Wang

Large language model (LLM) applications, such as ChatGPT, are a powerful tool for online information-seeking (IS) and problem-solving tasks. However, users still face challenges initializing and refining prompts, and their cognitive…

人机交互 · 计算机科学 2024-02-12 Ben Wang , Jiqun Liu , Jamshed Karimnazarov , Nicolas Thompson

As large language models (LLMs) become more capable, fine-tuning techniques for aligning with human intent are increasingly important. A key consideration for aligning these models is how to most effectively use human resources, or model…

机器学习 · 计算机科学 2024-07-01 William Muldrew , Peter Hayes , Mingtian Zhang , David Barber

Background: The potential of large language models (LLMs) to automate and support pharmacoepidemiologic study design is an emerging area of interest, yet their reliability remains insufficiently characterized. General-purpose LLMs often…

Questions are essential tools for acquiring the necessary information to complete information-seeking tasks. However, large language models (LLMs), especially open-source models, often perform poorly in generating informative questions, as…

计算与语言 · 计算机科学 2024-10-18 Davide Mazzaccara , Alberto Testoni , Raffaella Bernardi

Large language models (LLMs) such as ChatGPT have gained considerable interest across diverse research communities. Their notable ability for text completion and generation has inaugurated a novel paradigm for language-interfaced problem…

As large language models (LLMs) see greater use in academic and commercial settings, there is increasing interest in methods that allow language models to generate texts aligned with human preferences. In this paper, we present an initial…

机器学习 · 计算机科学 2024-06-07 Victoria Lin , Eli Ben-Michael , Louis-Philippe Morency

Scientific research indicates that for every hour spent in direct patient care, physicians spend nearly two additional hours on administrative tasks, particularly on electronic health records (EHRs) and desk work. This excessive…

计算与语言 · 计算机科学 2025-09-25 Hui Yi Leong , Yi Fan Gao , Ji Shuai , Yang Zhang , Uktu Pamuksuz

Aligning large language models (LLMs) depends on high-quality datasets of human preference labels, which are costly to collect. Although active learning has been studied to improve sample efficiency relative to passive collection, many…

机器学习 · 计算机科学 2026-02-03 Yao Zhao , Kwang-Sung Jun

Multi-objective preference alignment of large language models (LLMs) is critical for developing AI systems that are more configurable, personalizable, helpful, and safe. However, optimizing model outputs to satisfy diverse objectives with…

计算与语言 · 计算机科学 2025-03-04 Raghav Gupta , Ryan Sullivan , Yunxuan Li , Samrat Phatale , Abhinav Rastogi

Large Language Models (LLMs) demonstrate strong generalization and reasoning abilities, making them well-suited for complex decision-making tasks such as medical consultation (MC). However, existing LLM-based methods often fail to capture…

计算与语言 · 计算机科学 2025-10-13 Zhihao Jia , Mingyi Jia , Junwen Duan , Jianxin Wang

Effective training of language models (LMs) for mathematical reasoning tasks demands high-quality supervised fine-tuning data. Besides obtaining annotations from human experts, a common alternative is sampling from larger and more powerful…

计算与语言 · 计算机科学 2024-07-26 Tianduo Wang , Shichen Li , Wei Lu

Large language models (LLMs) have shown remarkable performance on many tasks in different domains. However, their performance in closed-book biomedical machine reading comprehension (MRC) has not been evaluated in depth. In this work, we…

计算与语言 · 计算机科学 2024-10-28 Shubham Vatsal , Ayush Singh

Aligning large language models (LLMs) with human intentions has become a critical task for safely deploying models in real-world systems. While existing alignment approaches have seen empirical success, theoretically understanding how these…

机器学习 · 计算机科学 2024-08-08 Shawn Im , Yixuan Li

Importance: We introduce a novel Retrieval Augmented Generation (RAG)-Large Language Model (LLM) framework as a Clinical Decision Support Systems (CDSS) to support safe medication prescription. Objective: To evaluate the efficacy of…

Large Language Models (LLMs) excel in handling general knowledge tasks, yet they struggle with user-specific personalization, such as understanding individual emotions, writing styles, and preferences. Personalized Large Language Models…

人工智能 · 计算机科学 2025-09-23 Jiahong Liu , Zexuan Qiu , Zhongyang Li , Quanyu Dai , Wenhao Yu , Jieming Zhu , Minda Hu , Menglin Yang , Tat-Seng Chua , Irwin King

Advancements in large language models (LLMs) have demonstrated remarkable capabilities across a diverse range of applications. These models excel in generating text completions that are contextually coherent and cover an extensive array of…

计算与语言 · 计算机科学 2024-01-22 Bradley Butcher

Human preference alignment can greatly enhance Multimodal Large Language Models (MLLMs), but collecting high-quality preference data is costly. A promising solution is the self-evolution strategy, where models are iteratively trained on…

机器学习 · 计算机科学 2024-12-23 Wentao Tan , Qiong Cao , Yibing Zhan , Chao Xue , Changxing Ding