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Systematic identification of protein function is a key problem in current biology. Most traditional methods fail to identify functionally equivalent proteins if they lack similar sequences, structural data or extensive manual annotations.…

基因组学 · 定量生物学 2016-03-08 Dan Ofer

Genotype imputation enables dense variant coverage for genome-wide association and risk-prediction studies, yet conventional reference-panel methods remain limited by ancestry bias and reduced rare-variant accuracy. We present Genotype…

Graph network science is becoming increasingly popular, notably in big-data perspective where understanding individual entities for individual functional roles is complex and time consuming. It is likely when a set of genes are regulated by…

基因组学 · 定量生物学 2021-03-11 Abhishek Narain Singh

Proteins play a vital role in biological processes and are indispensable for living organisms. Accurate representation of proteins is crucial, especially in drug development. Recently, there has been a notable increase in interest in…

生物大分子 · 定量生物学 2026-05-28 Dan Kalifa , Uriel Singer , Kira Radinsky

The capability of accurate prediction of protein functions and properties is essential in the biotechnology industry, e.g. drug development and artificial protein synthesis, etc. The main challenges of protein function prediction are the…

定量方法 · 定量生物学 2021-12-02 Wei-Cheng Tseng , Po-Han Chi , Jia-Hua Wu , Min Sun

Graph neural networks (GNNs) are shown to be successful in modeling applications with graph structures. However, training an accurate GNN model requires a large collection of labeled data and expressive features, which might be inaccessible…

机器学习 · 计算机科学 2019-06-03 Ziniu Hu , Changjun Fan , Ting Chen , Kai-Wei Chang , Yizhou Sun

Predicting the subsequent event for an existing event context is an important but challenging task, as it requires understanding the underlying relationship between events. Previous methods propose to retrieve relational features from event…

计算与语言 · 计算机科学 2022-05-24 Li Du , Xiao Ding , Yue Zhang , Kai Xiong , Ting Liu , Bing Qin

Graphs can model complex relationships between objects, enabling a myriad of Web applications such as online page/article classification and social recommendation. While graph neural networks(GNNs) have emerged as a powerful tool for graph…

机器学习 · 计算机科学 2023-02-28 Zemin Liu , Xingtong Yu , Yuan Fang , Xinming Zhang

In this study, we implement a novel BERT architecture for multitask fine-tuning on three downstream tasks: sentiment classification, paraphrase detection, and semantic textual similarity prediction. Our model, Multitask BERT, incorporates…

计算与语言 · 计算机科学 2024-08-29 Christopher Sun , Abishek Satish

Article prediction is a task that has long defied accurate linguistic description. As such, this task is ideally suited to evaluate models on their ability to emulate native-speaker intuition. To this end, we compare the performance of…

计算与语言 · 计算机科学 2022-06-10 Harish Tayyar Madabushi , Dagmar Divjak , Petar Milin

Graph Neural Networks (GNNs) achieve strong performance on node classification tasks but remain difficult to interpret, particularly with respect to which input features drive their predictions. Existing global GNN explainers operate at the…

机器学习 · 计算机科学 2026-05-06 Rishi Raj Sahoo , Subhankar Mishra

The identification of essential genes/proteins is a critical step towards a better understanding of human biology and pathology. Computational approaches helped to mitigate experimental constraints by exploring machine learning (ML) methods…

分子网络 · 定量生物学 2021-08-02 João Schapke , Anderson Tavares , Mariana Recamonde-Mendoza

Although syntactic information is beneficial for many NLP tasks, combining it with contextual information between words to solve the coreference resolution problem needs to be further explored. In this paper, we propose an end-to-end parser…

计算与语言 · 计算机科学 2023-09-12 Yuan Meng , Xuhao Pan , Jun Chang , Yue Wang

Pre-trained models for programming language have achieved dramatic empirical improvements on a variety of code-related tasks such as code search, code completion, code summarization, etc. However, existing pre-trained models regard a code…

Understanding protein structure-function relationships is a key challenge in computational biology, with applications across the biotechnology and pharmaceutical industries. While it is known that protein structure directly impacts protein…

生物大分子 · 定量生物学 2020-11-02 Nicolas Swenson , Aditi S. Krishnapriyan , Aydin Buluc , Dmitriy Morozov , Katherine Yelick

Relation prediction in knowledge graphs is dominated by embedding based methods which mainly focus on the transductive setting. Unfortunately, they are not able to handle inductive learning where unseen entities and relations are present…

计算与语言 · 计算机科学 2021-03-15 Hanwen Zha , Zhiyu Chen , Xifeng Yan

We study the problem of incorporating prior knowledge into a deep Transformer-based model,i.e.,Bidirectional Encoder Representations from Transformers (BERT), to enhance its performance on semantic textual matching tasks. By probing and…

计算与语言 · 计算机科学 2021-02-23 Tingyu Xia , Yue Wang , Yuan Tian , Yi Chang

While deep learning has achieved great success in many fields, one common criticism about deep learning is its lack of interpretability. In most cases, the hidden units in a deep neural network do not have a clear semantic meaning or…

基因组学 · 定量生物学 2019-06-04 Tianle Ma , Aidong Zhang

Gene studies are crucial for fields such as protein structure prediction, drug discovery, and cancer genomics, yet they face challenges in fully utilizing the vast and diverse information available. Gene studies require clean, factual…

数据库 · 计算机科学 2024-12-18 Yuwei Miao , Yuzhi Guo , Hehuan Ma , Jingquan Yan , Feng Jiang , Weizhi An , Jean Gao , Junzhou Huang

We introduce a new language representation model called BERT, which stands for Bidirectional Encoder Representations from Transformers. Unlike recent language representation models, BERT is designed to pre-train deep bidirectional…

计算与语言 · 计算机科学 2019-05-28 Jacob Devlin , Ming-Wei Chang , Kenton Lee , Kristina Toutanova