相关论文: Learning Cross-Domain Representations for Transfer…

Phenotype-based screening has attracted much attention for identifying cell-active compounds. Transcriptional and proteomic profiles of cell population or single cells are informative phenotypic measures of cellular responses to…

Accurate and robust drug response prediction is of utmost importance in precision medicine. Although many models have been developed to utilize the representations of drugs and cancer cell lines for predicting cancer drug responses (CDR),…

To successfully apply trained neural network models to new domains, powerful transfer learning solutions are essential. We propose to introduce a novel cross-domain latent modulation mechanism to a variational autoencoder framework so as to…

Self-supervised learning has demonstrated considerable potential in hyperspectral representation, yet its application in cross-domain transfer scenarios remains under-explored. Existing methods, however, still rely on source domain…

Microscopy-based phenotypic profiling is scalable for drug discovery but lacks the mechanistic depth of transcriptomics, which remains costly and scarce. Existing multimodal approaches either use images to support other modalities or…

While representation learning aims to derive interpretable features for describing visual data, representation disentanglement further results in such features so that particular image attributes can be identified and manipulated. However,…

Predicting drug response in patients from preclinical data remains a major challenge in precision oncology due to the substantial biological gap between in vitro cell lines and patient tumors. Rather than aiming to improve absolute in vitro…

Domain adaptation refers to the process of learning prediction models in a target domain by making use of data from a source domain. Many classic methods solve the domain adaptation problem by establishing a common latent space, which may…

Cross-domain recommendation (CDR) is crucial for improving recommendation accuracy and generalization, yet traditional methods are often hindered by the reliance on shared user/item IDs, which are unavailable in most real-world scenarios.…

When reliable target structures are unavailable at scale or phenotypes arise from dysregulated pathways, transcriptomic perturbations provide a system-level functional readout for drug action. In this work, we formalize…

In the field of image-based drug discovery, capturing the phenotypic response of cells to various drug treatments and perturbations is a crucial step. However, existing methods require computationally extensive and complex multi-step…

CDR (Cross-Domain Recommendation), i.e., leveraging information from multiple domains, is a critical solution to data sparsity problem in recommendation system. The majority of previous research either focused on single-target CDR (STCDR)…

In the problem of domain transfer learning, we learn a model for the predic-tion in a target domain from the data of both some source domains and the target domain, where the target domain is in lack of labels while the source domain has…

Cross-domain recommendation (CDR) aims to alleviate the data sparsity by transferring knowledge across domains. Disentangled representation learning provides an effective solution to model complex user preferences by separating intra-domain…

Emerging diseases present challenges in symptom recognition and timely clinical intervention due to limited available information. An effective prognostic model could assist physicians in making accurate diagnoses and designing personalized…

Contrastive learning has shown to learn better quality representations than models trained using cross-entropy loss. They also transfer better to downstream datasets from different domains. However, little work has been done to explore the…

In this paper, we present DRANet, a network architecture that disentangles image representations and transfers the visual attributes in a latent space for unsupervised cross-domain adaptation. Unlike the existing domain adaptation methods…

The study of cells and their responses to genetic or chemical perturbations promises to accelerate the discovery of therapeutic targets. However, designing adequate and insightful models for such data is difficult because the response of a…

Transformer-based models have achieved remarkable success in natural language and vision tasks, but their application to gene expression analysis remains limited due to data sparsity, high dimensionality, and missing values. We present…

Predicting drug-induced cellular state changes at single-cell resolution remains a central challenge in virtual cell modeling, particularly under out-of-distribution (OOD) conditions. Current approaches predominantly rely on RNA-based…