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Fluorescence microscopy is a key driver to promote discoveries of biomedical research. However, with the limitation of microscope hardware and characteristics of the observed samples, the fluorescence microscopy images are susceptible to…

图像与视频处理 · 电气工程与系统科学 2022-09-15 Xuanyu Tian , Qing Wu , Hongjiang Wei , Yuyao Zhang

Fluorescence microscopy has enabled a dramatic development in modern biology. Due to its inherently weak signal, fluorescence microscopy is not only much noisier than photography, but also presented with Poisson-Gaussian noise where Poisson…

计算机视觉与模式识别 · 计算机科学 2019-04-09 Yide Zhang , Yinhao Zhu , Evan Nichols , Qingfei Wang , Siyuan Zhang , Cody Smith , Scott Howard

Magnetic resonance imaging (MRI) is a powerful noninvasive diagnostic imaging tool that provides unparalleled soft tissue contrast and anatomical detail. Noise contamination, especially in accelerated and/or low-field acquisitions, can…

图像与视频处理 · 电气工程与系统科学 2025-05-12 Jiachen Tu , Yaokun Shi , Fan Lam

Image denoising is a fundamental problem in computer vision and medical imaging. However, real-world images are often degraded by structured noise with strong anisotropic correlations that existing methods struggle to remove. Most…

图像与视频处理 · 电气工程与系统科学 2025-10-03 Jianxu Wang , Ge Wang

Self-supervised image denoising techniques emerged as convenient methods that allow training denoising models without requiring ground-truth noise-free data. Existing methods usually optimize loss metrics that are calculated from multiple…

Image enhancement approaches often assume that the noise is signal independent, and approximate the degradation model as zero-mean additive Gaussian. However, this assumption does not hold for biomedical imaging systems where sensor-based…

图像与视频处理 · 电气工程与系统科学 2023-04-10 Calvin-Khang Ta , Abhishek Aich , Akash Gupta , Amit K. Roy-Chowdhury

Fluoroscopy is critical for real-time X-ray visualization in medical imaging. However, low-dose images are compromised by noise, potentially affecting diagnostic accuracy. Noise reduction is crucial for maintaining image quality, especially…

图像与视频处理 · 电气工程与系统科学 2024-11-05 Sun-Young Jeon , Sen Wang , Adam S. Wang , Garry E. Gold , Jang-Hwan Choi

Noise in low-dose computed tomography (LDCT) can obscure important diagnostic details. While deep learning offers powerful denoising, supervised methods require impractical paired data, and self-supervised alternatives often use opaque,…

图像与视频处理 · 电气工程与系统科学 2026-02-19 Yipeng Sun , Linda-Sophie Schneider , Siyuan Mei , Jinhua Wang , Ge Hu , Mingxuan Gu , Chengze Ye , Fabian Wagner , Lan Song , Siming Bayer , Andreas Maier

Image denoising is a prerequisite for downstream tasks in many fields. Low-dose and photon-counting computed tomography (CT) denoising can optimize diagnostic performance at minimized radiation dose. Supervised deep denoising methods are…

机器学习 · 计算机科学 2022-01-06 Chuang Niu , Mengzhou Li , Fenglei Fan , Weiwen Wu , Xiaodong Guo , Qing Lyu , Ge Wang

Self-supervised blind denoising for Poisson-Gaussian noise remains a challenging task. Pseudo-supervised pairs constructed from single noisy images re-corrupt the signal and degrade the performance. The visible blindspots solve the…

计算机视觉与模式识别 · 计算机科学 2023-03-15 Zejin Wang , Jiazheng Liu , Hao Zhai , Hua Han

Low-light, long-exposure defocus deblurring remains a challenging problem due to the simultaneous presence of severe blur and complex biased noise. Existing methods typically rely on simplified noise assumptions, which limits their…

计算机视觉与模式识别 · 计算机科学 2026-05-26 Ziyan Huang , Lang Wu , Hongji Wang , Yifei Liu , Dongliang Tang , Hongqiao Wang

In the last several years deep learning based approaches have come to dominate many areas of computer vision, and image denoising is no exception. Neural networks can learn by example to map noisy images to clean images. However, access to…

图像与视频处理 · 电气工程与系统科学 2023-06-13 Jason Lequyer , Reuben Philip , Amit Sharma , Laurence Pelletier

Noise is an important issue for radiographic and tomographic imaging techniques. It becomes particularly critical in applications where additional constraints force a strong reduction of the Signal-to-Noise Ratio (SNR) per image. These…

计算机视觉与模式识别 · 计算机科学 2023-03-28 Yaroslav Zharov , Evelina Ametova , Rebecca Spiecker , Tilo Baumbach , Genoveva Burca , Vincent Heuveline

In fluorescence microscopy live-cell imaging, there is a critical trade-off between the signal-to-noise ratio and spatial resolution on one side, and the integrity of the biological sample on the other side. To obtain clean high-resolution…

图像与视频处理 · 电气工程与系统科学 2020-08-25 Ruofan Zhou , Majed El Helou , Daniel Sage , Thierry Laroche , Arne Seitz , Sabine Süsstrunk

We extend the blindspot model for self-supervised denoising to handle Poisson-Gaussian noise and introduce an improved training scheme that avoids hyperparameters and adapts the denoiser to the test data. Self-supervised models for…

图像与视频处理 · 电气工程与系统科学 2020-11-20 Wesley Khademi , Sonia Rao , Clare Minnerath , Guy Hagen , Jonathan Ventura

Current self-supervised denoising techniques achieve impressive results, yet their real-world application is frequently constrained by substantial computational and memory demands, necessitating a compromise between inference speed and…

计算机视觉与模式识别 · 计算机科学 2025-10-20 Tomáš Chobola , Julia A. Schnabel , Tingying Peng

Multimodal and multi-information microscopy techniques such as Fluorescence Lifetime Imaging Microscopy (FLIM) extend the informational channels beyond intensity-based fluorescence microscopy but suffer from reduced image quality due to…

图像与视频处理 · 电气工程与系统科学 2025-04-15 Hao Chen , Julian Najera , Dagmawit Geresu , Meenal Datta , Cody Smith , Scott Howard

Biomedical images are noisy. The imaging equipment itself has physical limitations, and the consequent experimental trade-offs between signal-to-noise ratio, acquisition speed, and imaging depth exacerbate the problem. Denoising is,…

图像与视频处理 · 电气工程与系统科学 2020-11-11 Mikhail Papkov , Kenny Roberts , Lee Ann Madissoon , Omer Bayraktar , Dmytro Fishman , Kaupo Palo , Leopold Parts

High-resolution electron microscopy (HREM) imaging technique is a powerful tool for directly visualizing a broad range of materials in real-space. However, it faces challenges in denoising due to ultra-low signal-to-noise ratio (SNR) and…

图像与视频处理 · 电气工程与系统科学 2024-11-20 Xuanyu Tian , Zhuoya Dong , Xiyue Lin , Yue Gao , Hongjiang Wei , Yanhang Ma , Jingyi Yu , Yuyao Zhang

Magnetic Resonance Imaging (MRI), including diffusion MRI (dMRI), serves as a ``microscope'' for anatomical structures and routinely mitigates the influence of low signal-to-noise ratio scans by compromising temporal or spatial resolution.…

图像与视频处理 · 电气工程与系统科学 2025-03-11 Chenxu Wu , Qingpeng Kong , Zihang Jiang , S. Kevin Zhou
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