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Clinical trial matching is a key process in health delivery and discovery. In practice, it is plagued by overwhelming unstructured data and unscalable manual processing. In this paper, we conduct a systematic study on scaling clinical trial…

Matching cancer patients to clinical trials is essential for advancing treatment and patient care. However, the inconsistent format of medical free text documents and complex trial eligibility criteria make this process extremely…

Recent advances in large language models (LLMs) show potential for clinical applications, such as clinical decision support and trial recommendations. However, the GPT-4 LLM predicts an excessive number of ICD codes for medical coding…

计算与语言 · 计算机科学 2023-11-27 Zhichao Yang , Sanjit Singh Batra , Joel Stremmel , Eran Halperin

Motivation: Automatic Anatomical Therapeutic Chemical (ATC) classification is a critical and highly competitive area of research in bioinformatics because of its potential for expediting drug develop-ment and research. Predicting an unknown…

定量方法 · 定量生物学 2021-08-09 Loris Nanni , Alessandra Lumini , Sheryl Brahnam

Meta-analyses statistically aggregate the findings of different randomized controlled trials (RCTs) to assess treatment effectiveness. Because this yields robust estimates of treatment effectiveness, results from meta-analyses are…

计算与语言 · 计算机科学 2024-07-26 Hye Sun Yun , David Pogrebitskiy , Iain J. Marshall , Byron C. Wallace

Clinical trial matching is the task of identifying trials for which patients may be potentially eligible. Typically, this task is labor-intensive and requires detailed verification of patient electronic health records (EHRs) against the…

Extracting patient information from unstructured text is a critical task in health decision-support and clinical research. Large language models (LLMs) have shown the potential to accelerate clinical curation via few-shot in-context…

计算与语言 · 计算机科学 2023-06-21 Zelalem Gero , Chandan Singh , Hao Cheng , Tristan Naumann , Michel Galley , Jianfeng Gao , Hoifung Poon

The application of large language models (LLMs) to healthcare information extraction has emerged as a promising approach. This study evaluates the classification performance of five open-source LLMs: GEMMA-3-27B-IT, LLAMA3-70B, LLAMA4-109B,…

计算与语言 · 计算机科学 2025-05-09 Yuting Guo , Abeed Sarker

Compliance checking is an essential part of a construction project. The recent rapid uptake of building information models (BIM) in the construction industry has created more opportunities for automated compliance checking (ACC). BIM…

计算与语言 · 计算机科学 2024-08-01 Stefan Fuchs , Michael Witbrock , Johannes Dimyadi , Robert Amor

This study investigates the application of large language models (LLMs), specifically GPT-3.5 and GPT-4, with Chain-of-Though (CoT) in the automatic scoring of student-written responses to science assessments. We focused on overcoming the…

计算与语言 · 计算机科学 2024-02-20 Gyeong-Geon Lee , Ehsan Latif , Xuansheng Wu , Ninghao Liu , Xiaoming Zhai

In this study, we investigate the use of large language models (LLMs), specifically ChatGPT, for structured deductive qualitative coding. While most current research emphasizes inductive coding applications, we address the underexplored…

人机交互 · 计算机科学 2025-07-22 Angjelin Hila , Elliott Hauser

Purpose: This study aims to use a large language model (LLM) to automate the generation of summaries from the CT simulation orders and evaluate its performance. Materials and Methods: A total of 607 CT simulation orders for patients were…

New medical treatment development requires multiple phases of clinical trials. Despite the significant human and financial costs of bringing a drug to market, less than 20% of drugs in testing will make it from the first phase to final…

计算与语言 · 计算机科学 2024-08-21 Michael Reinisch , Jianfeng He , Chenxi Liao , Sauleh Ahmad Siddiqui , Bei Xiao

Purpose: Large language models (LLMs) have proven performance for certain diagnostic tasks, however limited studies have evaluated their consistency in recommending appropriate medication regimens for a given diagnosis. Medication…

The linking of clinical entities is a crucial part of extracting structured information from clinical texts. It is the process of assigning a code from a medical ontology or classification to a phrase in the text. The International…

计算与语言 · 计算机科学 2025-09-08 Sylvia Vassileva , Ivan Koychev , Svetla Boytcheva

The ability to predict drug overdose risk from a patient's medical records is crucial for timely intervention and prevention. Traditional machine learning models have shown promise in analyzing longitudinal medical records for this task.…

人工智能 · 计算机科学 2025-04-17 Md Sultan Al Nahian , Chris Delcher , Daniel Harris , Peter Akpunonu , Ramakanth Kavuluru

Large Language Models (LLMs) have shown remarkable capabilities in language understanding and generation. Nonetheless, it was also witnessed that LLMs tend to produce inaccurate responses to specific queries. This deficiency can be traced…

计算与语言 · 计算机科学 2025-05-16 Dixuan Wang , Yanda Li , Junyuan Jiang , Zepeng Ding , Ziqin Luo , Guochao Jiang , Jiaqing Liang , Deqing Yang

Background: Structured information extraction from unstructured histopathology reports facilitates data accessibility for clinical research. Manual extraction by experts is time-consuming and expensive, limiting scalability. Large language…

The escalating volume of collected healthcare textual data presents a unique challenge for automated Multi-Label Text Classification (MLTC), which is primarily due to the scarcity of annotated texts for training and their nuanced nature.…

计算与语言 · 计算机科学 2025-03-04 Hajar Sakai , Sarah S. Lam

Large Language Models (LLMs) have emerged as transformative tools in the healthcare sector, demonstrating remarkable capabilities in natural language understanding and generation. However, their proficiency in numerical reasoning,…

人工智能 · 计算机科学 2025-01-27 Arjun R. Malghan