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Genetic engineering of cells has a range of applications in treating incurable diseases. Plasmid DNA is a popular choice of nucleic acid for cell engineering due to its low cost and stability. However, plasmid DNA must survive the…

A new general route for siRNA delivery is presented combining porous core-shell silica nanocarriers with a modularly designed multifunctional block copolymer. Specifically, the internal storage and release of siRNA from mesoporous silica…

亚细胞过程 · 定量生物学 2016-03-23 Karin Moeller , Katharina Mueller , Hanna Engelke , Christoph Braeuchle , Ernst Wagner , Thomas Bein

Effective and controlled drug delivery systems with on-demand release abilities and biocompatible properties receive enormous attention for biomedical applications. Here, we describe a novel inorganic-organic hybrid material with a…

软凝聚态物质 · 物理学 2015-09-09 Stefan Datz , Hanna Engelke , Constantin v. Schirnding , Linh Nguyen , Thomas Bein

We present an electrophoretic platform based on 3D hollow nanoelectrodes capable of controlling and quantifying the intracellular delivery of single nanoparticles in single selected cells by surface-enhanced Raman spectroscopy (SERS). The…

While RNA technologies hold immense therapeutic potential in a range of applications from vaccination to gene editing, the broad implementation of these technologies is hindered by the challenge of delivering these agents effectively. Lipid…

生物大分子 · 定量生物学 2023-08-30 Daisy Yi Ding , Yuhui Zhang , Yuan Jia , Jiuzhi Sun

Within the framework of a Device-to-Device (D2D) data offloading system for cellular networks, we propose a Content Delivery Management System (CDMS) in which the instant for transmitting a content to a requesting node, through a D2D…

网络与互联网体系结构 · 计算机科学 2022-05-31 Loreto Pescosolido , Marco Conti , Andrea Passarella

Implicit particle-in-cell codes offer advantages over their explicit counterparts in that they suffer weaker stability constraints on the need to resolve the higher frequency modes of the system. This feature may prove particularly valuable…

计算物理 · 物理学 2015-05-13 Mathieu Drouin , Laurent Gremillet , Jean-Claude Adam , Anne Héron

We model carrier transport in photonic crystal lasers with lateral current injection through two-dimensional (2D) finite-volume simulations. Though such lasers can achieve ultra-low threshold currents, leakage paths reduce the carrier…

By applying a slow curing process, we show that biomolecules can be incorporated via a simple process as liquid stable phases inside a polydimethylsiloxane (PDMS) matrix. The process is carried out under mild conditions with regards to…

Effective and controlled drug delivery systems with on-demand release and targeting abilities have received enormous attention for biomedical applications. Here, we describe a novel enzyme-based cap system for mesoporous silica…

Self-assembly of simple molecules into complex phases can be driven by physical constraints, for instance, due to selective molecular uptake by nanoporous surfaces. Despite the significance of surface-mediated assembly in evolution of life,…

软凝聚态物质 · 物理学 2023-11-07 Vamseekrishna Ulaganathan , Anupam Sengupta

Deploying fibrous membranes for passive daytime radiative cooling (PDRC) on large and irregular surfaces is highly desirable but remains challenging, owing to the slow deposition rates and the need for electrically conductive substrates in…

光学 · 物理学 2026-02-24 Hanzhuo Shao , Xiaoli Huang , Xuemei Huang , Jin Zhao , Nailin Xing , Hua Xu , Weijie Song , Yuehui Lu

The control of material properties at the atomic scale remains a central challenge in materials science. Transition metal dichalcogenides (TMDCs) offer remarkable electronic and optical properties, but their functionality is largely…

Carrier selective (CS) silicon solar cells are increasingly explored using a variety of different materials. However, the optimum properties of such CS materials are not well understood. In this context, through detailed analytical and…

应用物理 · 物理学 2017-04-24 Nithin Chatterji , Aldrin Antony , Pradeep R. Nair

Nanoparticle drug carriers play an important role in facilitating efficient targeted drug delivery, i.e., improving treatment success and reducing drug costs and side effects. However, the mobility of nanoparticle drug carriers poses a…

Technological advancements in generation of ultrafast and intense laser pulses have enabled the real-time observation and control of charge migration in molecules on their natural timescale, which ranges from few femtoseconds to several…

光学 · 物理学 2025-02-25 Sucharita Giri

The recent super-exponential growth in the amount of sequencing data generated worldwide has put techniques for compressed storage into the focus. Most available solutions, however, are strictly tied to specific bioinformatics formats,…

基因组学 · 定量生物学 2021-11-01 Łukasz Roguski , Paolo Ribeca

Atomically-thin molybdenum disulfide is emerging as a new nanomaterial with potential applications in the fields of electronic and photonics. Charge carrier dynamics plays an essential role in determining its electronic and optical…

介观与纳米尺度物理 · 物理学 2012-07-09 Rui Wang , Brian A. Ruzicka , Nardeep Kumar , Matthew Z. Bellus , Hsin-Ying Chiu , Hui Zhao

Biological studies on in vitro cell cultures are of fundamental importance to investigate cells response to external stimuli, such as new drugs for treatment of specific pathologies, or to study communication between electrogenic cells.…

Generative diffusion models have achieved remarkable success in producing high-quality images. However, these models typically operate in continuous intensity spaces, diffusing independently across pixels and color channels. As a result,…

图形学 · 计算机科学 2025-05-20 Javier E. Santos , Agnese Marcato , Roman Colman , Nicholas Lubbers , Yen Ting Lin
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