相关论文: S$^2$ALM: Sequence-Structure Pre-trained Large Lan…

A plethora of protein language models have been released in recent years. Yet comparatively little work has addressed how to best sample from them to optimize desired biological properties. We fill this gap by proposing a flexible,…

AlphaFold2 (AF2) has transformed protein structure prediction by harnessing co-evolutionary constraints embedded in multiple sequence alignments (MSAs). MSAs not only encode static structural information, but also hold critical details…

Embodied AI requires agents to understand goals, plan actions, and execute tasks in simulated environments. We present a comprehensive evaluation of Large Language Models (LLMs) on the VirtualHome benchmark using the Embodied Agent…

Large-scale audio language models (ALMs), such as Qwen2-Audio, are capable of comprehending diverse audio signal, performing audio analysis and generating textual responses. However, in speech emotion recognition (SER), ALMs often suffer…

In this paper, we address self-supervised representation learning from human skeletons for action recognition. Previous methods, which usually learn feature presentations from a single reconstruction task, may come across the overfitting…

Self-supervised learning (SSL), which aims to learn meaningful prior representations from unlabeled data, has been proven effective for skeleton-based action understanding. Different from the image domain, skeleton data possesses sparser…

SMILES, a crucial textual representation of molecular structures, has garnered significant attention as a foundation for pre-trained language models (LMs). However, most existing pre-trained SMILES LMs focus solely on the single-token level…

Recently, large pre-trained neural language models have attained remarkable performance on many downstream natural language processing (NLP) applications via fine-tuning. In this paper, we target at how to further improve the token…

This paper presents a novel training method, Conditional Masked Language Modeling (CMLM), to effectively learn sentence representations on large scale unlabeled corpora. CMLM integrates sentence representation learning into MLM training by…

Accurately measuring protein-RNA binding affinity is crucial in many biological processes and drug design. Previous computational methods for protein-RNA binding affinity prediction rely on either sequence or structure features, unable to…

A prior-informed large language model (LLM) driven multi-task learning framework is proposed for the unified description of multiple nuclear observables. By fine-tuning the pre-trained DeepSeek-R1-1.5B model with Low-Rank Adaptation (LoRA),…

Large audio language models (ALMs) extend LLMs with auditory understanding. A common approach freezes the LLM and trains only an adapter on self-generated targets. However, this fails for reasoning LLMs (RLMs) whose built-in…

We introduce AbDiffuser, an equivariant and physics-informed diffusion model for the joint generation of antibody 3D structures and sequences. AbDiffuser is built on top of a new representation of protein structure, relies on a novel…

Medical image-language pre-training aims to align medical images with clinically relevant text to improve model performance on various downstream tasks. However, existing models often struggle with the variability and ambiguity inherent in…

Compositional speech-to-speech translation (S2ST) systems built upon speech large language models (SpeechLLMs) have recently shown promising performance. However, existing S2ST systems often either neglect source-language information or…

Proteins inherently possess a consistent sequence-structure duality. The abundance of protein sequence data, which can be readily represented as discrete tokens, has driven fruitful developments in protein language models (pLMs). A key…

Deriving multimodal representations of audio and lexical inputs is a central problem in Natural Language Understanding (NLU). In this paper, we present Contrastive Aligned Audio-Language Multirate and Multimodal Representations (CALM), an…

Efficient encoding and representation of large 3D molecular structures with high fidelity is critical for biomolecular design applications. Despite this, many representation learning approaches restrict themselves to modeling smaller…

Self-supervised learning has recently gained growing interest in molecular modeling for scientific tasks such as AI-assisted drug discovery. Current studies consider leveraging both 2D and 3D molecular structures for representation…

Protein language models (PLMs) have demonstrated remarkable success in protein modeling and design, yet their internal mechanisms for predicting structure and function remain poorly understood. Here we present a systematic approach to…