相关论文: SeqProFT: Sequence-only Protein Property Predictio…

Pre-training Large Language Models (LLMs) on web-scale datasets becomes fundamental for advancing general-purpose AI. In contrast, enhancing their predictive performance on downstream tasks typically involves adapting their knowledge…

Fine-tuning large language models (LLMs) aims to adapt pre-trained models to specific tasks using relatively small and domain-specific datasets. Among Parameter-Efficient Fine-Tuning (PEFT) methods, Low-Rank Adaptation (LoRA) stands out by…

Large language models (LLMs) have demonstrated significant success in natural language processing (NLP) tasks and have shown promising results in other domains such as protein sequence generation. However, there remain salient differences…

Supervised fine-tuning (SFT) is a standard approach for adapting large language models to specialized domains, yet its application to protein sequence modeling and protein language models (PLMs) remains ad hoc. This is in part because…

Parameter-efficient fine-tuning (PEFT) is a popular method for tailoring pre-trained large language models (LLMs), especially as the models' scale and the diversity of tasks increase. Low-rank adaptation (LoRA) is based on the idea that the…

Understanding biological processes, drug development, and biotechnological advancements requires a detailed analysis of protein structures and functions, a task that is inherently complex and time-consuming in traditional protein research.…

Pre-trained LLMs have demonstrated substantial capabilities across a range of conventional natural language processing (NLP) tasks, such as summarization and entity recognition. In this paper, we explore the application of LLMs in the…

Parameter-Efficient Fine-Tuning (PEFT) is widely used for adapting Large Language Models (LLMs) for various tasks. Recently, there has been an increasing demand for fine-tuning a single LLM for multiple tasks because it requires overall…

Low-rank Adaptation (LoRA) has gained popularity as a fine-tuning approach for Large Language Models (LLMs) due to its low resource requirements and good performance. While a plethora of work has investigated improving LoRA serving…

The parallels between protein sequences and natural language in their sequential structures have inspired the application of large language models (LLMs) to protein understanding. Despite the success of LLMs in NLP, their effectiveness in…

Parameter-Efficient Fine-Tuning (PEFT), particularly Low-Rank Adaptation (LoRA), has become a standard approach for adapting Large Language Models (LLMs) under limited compute. However, in continual settings where models are updated…

Low Rank Adaptation (LoRA) has emerged as one of the most widely adopted methods for Parameter Efficient Fine-Tuning (PEFT) of Large Language Models (LLMs). LoRA reduces the number of trainable parameters and memory usage while achieving…

Fine-tuning is a key approach for adapting language models to specific downstream tasks, but updating all model parameters becomes impractical as model sizes increase. Parameter-Efficient Fine-Tuning (PEFT) methods, such as Low-Rank…

Fine-tuning large language models (LLMs) with high parameter efficiency for downstream tasks has become a new paradigm. Low-Rank Adaptation (LoRA) significantly reduces the number of trainable parameters for fine-tuning. Although it has…

Adapting large language models (LLMs) to downstream tasks via full fine-tuning is increasingly impractical due to its computational and memory demands. Parameter-efficient fine-tuning (PEFT) approaches such as Low-Rank Adaptation (LoRA)…

The scaling law of Large Language Models (LLMs) reveals a power-law relationship, showing diminishing return on performance as model scale increases. While training LLMs from scratch is resource-intensive, fine-tuning a pre-trained model…

Large Language Models (LLMs) have transformed both everyday life and scientific research. However, adapting LLMs from general-purpose models to specialized tasks remains challenging, particularly in resource-constrained environments.…

Current Large Language Models (LLMs) for understanding proteins primarily treats amino acid sequences as a text modality. Meanwhile, Protein Language Models (PLMs), such as ESM-2, have learned massive sequential evolutionary knowledge from…

Recent advances in Protein Language Models (PLMs) have transformed protein engineering, yet unlike their counterparts in Natural Language Processing (NLP), current PLMs exhibit a fundamental limitation: they excel in either Protein Language…

Adapting Large Language Models (LLMs) to new tasks through fine-tuning has been made more efficient by the introduction of Parameter-Efficient Fine-Tuning (PEFT) techniques, such as LoRA. However, these methods often underperform compared…