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We developed a positron emission tomography (PET) system for multiple-isotope imaging. Our PET system, named multiple-isotope PET (MI-PET), can distinguish between different tracer nuclides using coincidence measurement of prompt…

Positronium Imaging requires two classes of events: double-coincidences originated from pair of back-to-back annihilation photons and triple-coincidences comprised with two annihilation photons and one additional prompt photon. The standard…

医学物理 · 物理学 2025-08-11 Lech Raczynski , Wojciech Krzemien , Konrad Klimaszewski

We report on an hybrid in-beam PET and prompt-gamma Compton imaging system aimed at quasi real-time ion-range verification in proton-therapy treatments. Proof-of-concept experiments were carried out at the radiobiology beam line of the CNA…

Positron emission tomography (PET) is widely used to assess metabolic activity, but its application is limited by the availability of radiotracers. 18F-labeled fluorodeoxyglucose (18F-FDG) is the most commonly used tracer but shows limited…

图像与视频处理 · 电气工程与系统科学 2025-06-24 Fang Chen , Weifeng Zhang , Xingyu Ai , BingXuan Li , An Li , Qiegen Liu

We propose PET scanners using low atomic number media that undergo a persistent local change of state along the paths of the Compton recoil electrons. Measurement of the individual scattering locations and angles, deposited energies, and…

MultiModal Imaging is an innovative technique that consists in the combination of diagnostic exams based on different physical processes, to obtain a unique image with more detailed clinical information. The possibility of a simultaneous…

医学物理 · 物理学 2020-06-23 A. Colombi , F. Barbaro , L. Canton , M. P. Carante , A. Fontana

Photomultipliers are commonly used in commercial PET scanner as devices which convert light produced in scintillator by gamma quanta from positron-electron annihilation into electrical signal. For proper analysis of obtained electrical…

This paper describes the characterization of crystal matrices and silicon photomultiplier arrays for a novel Positron Emission Tomography (PET) detector, namely the external plate of the EndoTOFPET-US system. The EndoTOFPET-US collaboration…

We present a nuclear medical imaging technique, employing triple-gamma trajectory intersections from beta^+ - gamma coincidences, able to reach sub-millimeter spatial resolution in 3 dimensions with a reduced requirement of reconstructed…

医学物理 · 物理学 2014-02-18 C. Lang , D. Habs , K. Parodi , P. G. Thirolf

Improving the coincidence time resolution (CTR) of time-of-flight positron emission tomography (TOF-PET) systems to achieve a higher signal-to-noise ratio (SNR) gain or even direct positron emission imaging (dPEI) is of paramount importance…

Modern PET systems reach a spatial resolution of 3-10 mm. A disadvantage of this technique is the diffusion of the positron before its decay with a typical range of ca. 1 mm (depending on its energy). This motion and Compton scattering of…

仪器与探测器 · 物理学 2012-02-03 C. Lang , D. Habs , P. G. Thirolf , A. Zoglauer

In clinical practice, single-radiotracer positron emission tomography (PET) is commonly used for imaging. Although multi-tracer PET imaging can provide supplementary information of radiotracers that are sensitive to physiological function…

图像与视频处理 · 电气工程与系统科学 2025-06-23 Bin Huang , Feihong Xu , Xinchong Shi , Shan Huang , Binxuan Li , Fei Li , Qiegen Liu

The measurement of the time of flight of the two 511 keV gammas recorded in coincidence in a PET scanner provides an effective way of reducing the random background and therefore increases the scanner sensitivity, provided that the…

仪器与探测器 · 物理学 2016-10-12 J. J Gomez-Cadenas , J. M. Benlloch-Rodríguez , P. Ferrario , F. Monrabal , J. Rodríguez , J. F. Toledo

Positron Emission Tomography using 2-[18F]-2deoxy-D-glucose as radiotracer (FDG-PET) is currently one of the most frequently applied functional imaging methods in clinical applications. The interpretation of FDG-PET data requires…

组织与器官 · 定量生物学 2020-01-22 Michele Piana , Giacomo Caviglia , Sara Sommariva

This work explores the combination of liquid xenon as a scintillating medium and silicon photomultipliers as a readout in Positron Emission Tomography (PET) for enhanced Time-Of-Flight resolution. We present the results of our first…

Metabolic imaging with PET/CT using $^{18}$F-Fludeoxyglucose ($^{18}$F-FDG) as well as other imaging biomarkers has achieved wide acceptance in oncology, cardiology and neurology not only because of the unique metabolic information…

医学物理 · 物理学 2020-06-09 Zhenzhou Deng , Xin Zhao , Anyi Li

For long time non-pure beta emitters are avoided from PET imaging due to extra dose and increase in background from Compton scattering. But advent of high-resolution Compton camera system opens up new domain of imaging. Various non-pure…

医学物理 · 物理学 2021-10-06 Satyajit Ghosh , Pragya Das

For its ease manufacturing, flexible geometry, and cheap manufacturing cost, the gas electron multiplier (GEM) detector can be used as an x-ray image sensor. For this purpose, we acquired relative detection efficiencies and suggested a…

仪器与探测器 · 物理学 2015-03-13 Sukyoung Shin , Jaehoon Jung , Soonhyouk Lee

A PET scanner based on silicon photomultipliers (SiPMs) has been widely used as an advanced nuclear medicine imaging technique that yields quantitative images of regional in vivo biology and biochemistry. The compact size of the SiPM allows…

仪器与探测器 · 物理学 2022-02-02 Cong Ma , Xiaokun Zhao , Size Gao , Fengping Zhang , Guocheng Wu , Xing Li , Lei Lu , Hongwei Ye , Hua Qian

Positron Emission Tomography (PET) is a medical imaging modality that utilizes positron-emitting isotopes, such as Ga-68 and F-18, for many diagnostic purposes. The positron annihilates with an electron from the surrounding area, creating…

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