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Systematic reviews are crucial for synthesizing scientific evidence but remain labor-intensive, especially when extracting detailed methodological information. Large language models (LLMs) offer potential for automating methodological…

计算与语言 · 计算机科学 2025-10-14 Wenqing Zhang , Trang Nguyen , Elizabeth A. Stuart , Yiqun T. Chen

Research scientists increasingly rely on implementing software to support their research. While previous research has examined the impact of identifier names on program comprehension in traditional programming environments, limited work has…

软件工程 · 计算机科学 2025-07-23 Gunnar Larsen , Carol Wong , Anthony Peruma

Objective: To demonstrate the capabilities of Large Language Models (LLMs) as autonomous agents to reproduce findings of published research studies using the same or similar dataset. Materials and Methods: We used the "Quick Access" dataset…

计算与语言 · 计算机科学 2025-06-02 Nic Dobbins , Christelle Xiong , Kristine Lan , Meliha Yetisgen

Large language models (LLMs) have shown potential in biomedical applications, leading to efforts to fine-tune them on domain-specific data. However, the effectiveness of this approach remains unclear. This study evaluates the performance of…

Aligning terminological resources, including ontologies, controlled vocabularies, taxonomies, and value sets is a critical part of data integration in many domains such as healthcare, chemistry, and biomedical research. Entity mapping is…

Large Language Models (LLMs) are transforming language sciences. However, their widespread deployment currently suffers from methodological fragmentation and a lack of systematic soundness. This study proposes two comprehensive…

计算与语言 · 计算机科学 2025-12-11 Kun Sun , Rong Wang

Large Language Models (LLMs) have demonstrated impressive performance in biomedical relation extraction, even in zero-shot scenarios. However, evaluating LLMs in this task remains challenging due to their ability to generate human-like…

计算与语言 · 计算机科学 2025-06-03 Md Tahmid Rahman Laskar , Israt Jahan , Elham Dolatabadi , Chun Peng , Enamul Hoque , Jimmy Huang

Biomedical literature often uses complex language and inaccessible professional terminologies. That is why simplification plays an important role in improving public health literacy. Applying Natural Language Processing (NLP) models to…

计算与语言 · 计算机科学 2024-03-19 Zihao Li , Samuel Belkadi , Nicolo Micheletti , Lifeng Han , Matthew Shardlow , Goran Nenadic

Large language models (LLMs) are increasingly used as automated judges to evaluate recommendation systems, search engines, and other subjective tasks, where relying on human evaluators can be costly, time-consuming, and unscalable. LLMs…

计算与语言 · 计算机科学 2025-02-10 Gerrit J. J. van den Burg , Gen Suzuki , Wei Liu , Murat Sensoy

Clinical diagnosis prediction models, when provided with a patient's medical history, aim to detect potential diseases early, facilitating timely intervention and improving prognostic outcomes. However, the inherent scarcity of patient data…

计算与语言 · 计算机科学 2025-01-30 Mingyu Derek Ma , Xiaoxuan Wang , Yijia Xiao , Anthony Cuturrufo , Vijay S Nori , Eran Halperin , Wei Wang

The biomedical domain has sparked a significant interest in the field of Natural Language Processing (NLP), which has seen substantial advancements with pre-trained language models (PLMs). However, comparing these models has proven…

Natural language generation (NLG) tasks are often subject to inherent variability; e.g. predicting the next word given a context has multiple valid responses, evident when asking multiple humans to complete the task. While having language…

计算与语言 · 计算机科学 2025-10-08 Tobias Groot , Salo Lacunes , Evgenia Ilia

Large language models (LLMs) frequently achieve impressive scores on standardized benchmarks, yet accuracy alone offers a limited view of their capabilities. Evaluating open-source LLMs through leaderboards faces persistent issues like data…

For years, semantic interoperability standards have sought to streamline the exchange of clinical data, yet their deployment remains time-consuming, resource-intensive, and technically challenging. To address this, we introduce a…

计算与语言 · 计算机科学 2025-07-08 Alvaro Riquelme , Pedro Costa , Catalina Martinez

Large language models (LLMs) solve reasoning problems by first generating a rationale and then answering. We formalize reasoning as a latent variable model and derive a reward-based filtered expectation-maximization (FEM) objective for…

机器学习 · 计算机科学 2026-02-03 Junghyun Lee , Branislav Kveton , Anup Rao , Subhojyoti Mukherjee , Ryan A. Rossi , Sunav Choudhary , Alexa Siu

Recent studies have demonstrated the feasibility of modeling single-cell data as natural languages and the potential of leveraging powerful large language models (LLMs) for understanding cell biology. However, a comprehensive evaluation of…

定量方法 · 定量生物学 2025-05-14 Fan Zhang , Tianyu Liu , Zhihong Zhu , Hao Wu , Haixin Wang , Donghao Zhou , Yefeng Zheng , Kun Wang , Xian Wu , Pheng-Ann Heng

The scarcity of high-quality annotated medical data, particularly in mental health, poses a significant bottleneck for training robust machine learning models. Privacy regulations restrict data sharing, making synthetic data generation a…

Large language models (LLMs) excel on multiple-choice clinical diagnosis benchmarks, yet it is unclear how much of this performance reflects underlying probabilistic reasoning. We study this through questions from MedQA, where the task is…

计算与语言 · 计算机科学 2025-12-16 Furong Jia , Yuan Pu , Finn Guo , Monica Agrawal

Large language models (LLMs) often lack specialized knowledge for complex bioinformatics applications. We present a reproducible pipeline for fine-tuning LLMs on specialized bioinformatics data, demonstrated through two use cases: PRSGPT,…

计算与语言 · 计算机科学 2026-01-21 Muhammad Muneeb , David B. Ascher

In the rapidly evolving field of Explainable Natural Language Processing (NLP), textual explanations, i.e., human-like rationales, are pivotal for explaining model predictions and enriching datasets with interpretable labels. Traditional…

计算与语言 · 计算机科学 2025-11-12 Mahdi Dhaini , Juraj Vladika , Ege Erdogan , Zineb Attaoui , Gjergji Kasneci