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An accurate differential diagnosis (DDx) is a cornerstone of medical care, often reached through an iterative process of interpretation that combines clinical history, physical examination, investigations and procedures. Interactive…

Background: Large language models (LLMs) such as OpenAI's GPT-4 or Google's PaLM 2 are proposed as viable diagnostic support tools or even spoken of as replacements for "curbside consults". However, even LLMs specifically trained on medical…

人工智能 · 计算机科学 2024-10-21 Gioele Barabucci , Victor Shia , Eugene Chu , Benjamin Harack , Nathan Fu

Radiology reports summarize key findings and differential diagnoses derived from medical imaging examinations. The extraction of differential diagnoses is crucial for downstream tasks, including patient management and treatment planning.…

计算与语言 · 计算机科学 2024-10-15 Luoyao Chen , Revant Teotia , Antonio Verdone , Aidan Cardall , Lakshay Tyagi , Yiqiu Shen , Sumit Chopra

Automatic differential diagnosis (DDx) is an essential medical task that generates a list of potential diseases as differentials based on patient symptom descriptions. In practice, interpreting these differential diagnoses yields…

计算与语言 · 计算机科学 2024-11-08 Shuang Zhou , Mingquan Lin , Sirui Ding , Jiashuo Wang , Genevieve B. Melton , James Zou , Rui Zhang

An accurate differential diagnosis (DDx) is essential for patient care, shaping therapeutic decisions and influencing outcomes. Recently, Large Language Models (LLMs) have emerged as promising tools to support this process by generating a…

人工智能 · 计算机科学 2025-10-07 Seungseop Lim , Gibaeg Kim , Hyunkyung Lee , Wooseok Han , Jean Seo , Jaehyo Yoo , Eunho Yang

Lab results are often confusing and hard to understand. Large language models (LLMs) such as ChatGPT have opened a promising avenue for patients to get their questions answered. We aim to assess the feasibility of using LLMs to generate…

计算与语言 · 计算机科学 2024-04-23 Zhe He , Balu Bhasuran , Qiao Jin , Shubo Tian , Karim Hanna , Cindy Shavor , Lisbeth Garcia Arguello , Patrick Murray , Zhiyong Lu

The recent swift development of LLMs like GPT-4, Gemini, and GPT-3.5 offers a transformative opportunity in medicine and healthcare, especially in digital diagnostics. This study evaluates each model diagnostic abilities by interpreting a…

计算与语言 · 计算机科学 2024-05-14 Gaurav Kumar Gupta , Aditi Singh , Sijo Valayakkad Manikandan , Abul Ehtesham

Large language models (LLMs) are increasingly explored for clinical decision support, yet most evaluations are conducted in English, leaving their reliability in other languages uncertain. Here we evaluate the impact of prompting language…

计算与语言 · 计算机科学 2026-05-20 Adrien Bazoge , Josselin Corvellec , Sofiane Djillali Sid-Ahmed , Pierre-Antoine Gourraud

Large language models (LLMs) are increasingly attracting the attention of healthcare professionals for their potential to assist in diagnostic assessments, which could alleviate the strain on the healthcare system caused by a high patient…

计算与语言 · 计算机科学 2025-01-03 Kaushik Roy , Harshul Surana , Darssan Eswaramoorthi , Yuxin Zi , Vedant Palit , Ritvik Garimella , Amit Sheth

Large language models (LLMs) have demonstrated remarkable capabilities in natural language understanding and generation across various domains, including medicine. We present a comprehensive evaluation of GPT-4, a state-of-the-art LLM, on…

计算与语言 · 计算机科学 2023-04-13 Harsha Nori , Nicholas King , Scott Mayer McKinney , Dean Carignan , Eric Horvitz

In practice, clinicians achieve a diagnosis by following a sequence of steps, such as laboratory exams, observations, or imaging. The pathways to reach diagnosis decisions are documented by guidelines authored by expert organizations, which…

计算与语言 · 计算机科学 2024-09-25 Elisa Castagnari , Lillian Muyama , Adrien Coulet

Clinical Decision Support Systems (CDSS) utilize evidence-based knowledge and patient data to offer real-time recommendations, with Large Language Models (LLMs) emerging as a promising tool to generate plain-text explanations for medical…

计算与语言 · 计算机科学 2023-10-04 D. Umerenkov , G. Zubkova , A. Nesterov

Large language models (LLMs) have recently showcased remarkable capabilities, spanning a wide range of tasks and applications, including those in the medical domain. Models like GPT-4 excel in medical question answering but may face…

Large language models (LLMs) constitute a breakthrough state-of-the-art Artificial Intelligence technology which is rapidly evolving and promises to aid in medical diagnosis. However, the correctness and the accuracy of their returns has…

计算与语言 · 计算机科学 2024-02-07 Dimitrios P. Panagoulias , Maria Virvou , George A. Tsihrintzis

Diabetes mellitus is a major global health challenge, affecting over half a billion adults worldwide with prevalence projected to rise. Although the American Diabetes Association (ADA) provides clear diagnostic thresholds, early recognition…

计算与语言 · 计算机科学 2025-09-29 Gaurav Kumar Gupta , Nirajan Acharya , Pranal Pande

Clinical document classification is essential for converting unstructured medical texts into standardised ICD-10 diagnoses, yet it faces challenges due to complex medical language, privacy constraints, and limited annotated datasets. Large…

计算与语言 · 计算机科学 2026-02-03 Akram Mustafa , Usman Naseem , Mostafa Rahimi Azghadi

Large language models (LLMs) can simulate clinical reasoning based on natural language prompts, but their utility in ophthalmology is largely unexplored. This study evaluated GPT-4's ability to interpret structured textual descriptions of…

In recent years, groundbreaking advancements in natural language processing have culminated in the emergence of powerful large language models (LLMs), which have showcased remarkable capabilities across a vast array of domains, including…

计算与语言 · 计算机科学 2023-12-11 Microsoft Research AI4Science , Microsoft Azure Quantum

Large language models (LLMs) have demonstrated impressive performance across various domains. However, for clinical diagnosis, higher expectations are required for LLM's reliability and sensitivity: thinking like physicians and remaining…

计算与语言 · 计算机科学 2025-04-21 Chenwei Yan , Xiangling Fu , Yuxuan Xiong , Tianyi Wang , Siu Cheung Hui , Ji Wu , Xien Liu

Large language models (LLMs) have demonstrated capabilities across diverse domains, yet their performance on rare disease diagnosis from narrative medical cases remains underexplored. We introduce a novel dataset of 176 symptom-diagnosis…

计算与语言 · 计算机科学 2025-11-17 Arsh Gupta , Ajay Narayanan Sridhar , Bonam Mingole , Amulya Yadav
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