相关论文: One protein is all you need

Protein language models (PLMs) have emerged as powerful tools to detect complex patterns of protein sequences. However, the capability of PLMs to fully capture information on protein sequences might be limited by focusing on single…

In recent years, significant progress has been made in the field of protein function prediction with the development of various machine-learning approaches. However, most existing methods formulate the task as a multi-classification…

Attention-based models trained on protein sequences have demonstrated incredible success at classification and generation tasks relevant for artificial intelligence-driven protein design. However, we lack a sufficient understanding of how…

Protein function prediction is a pivotal task in drug discovery, significantly impacting the development of effective and safe therapeutics. Traditional machine learning models often struggle with the complexity and variability inherent in…

Recent work on time-series models has leveraged self-supervised training to learn meaningful features and patterns in order to improve performance on downstream tasks and generalize to unseen modalities. While these pretraining methods have…

Protein is linked to almost every life process. Therefore, analyzing the biological structure and property of protein sequences is critical to the exploration of life, as well as disease detection and drug discovery. Traditional protein…

This paper introduces a simple and scalable approach to improve the data efficiency of large language model (LLM) training by augmenting existing text data with thinking trajectories. The compute for pre-training LLMs has been growing at an…

We present Point-TTA, a novel test-time adaptation framework for point cloud registration (PCR) that improves the generalization and the performance of registration models. While learning-based approaches have achieved impressive progress,…

Pre-trained LLMs have demonstrated substantial capabilities across a range of conventional natural language processing (NLP) tasks, such as summarization and entity recognition. In this paper, we explore the application of LLMs in the…

Pre-trained large language models demonstrate potential in extracting information from DNA sequences, yet adapting to a variety of tasks and data modalities remains a challenge. To address this, we propose DNAGPT, a generalized DNA…

Protein structure prediction remains to be an open problem in bioinformatics. There are two main categories of methods for protein structure prediction: Free Modeling (FM) and Template Based Modeling (TBM). Protein threading, belonging to…

The recent rapid progress in pre-training Large Language Models has relied on using self-supervised language modeling objectives like next token prediction or span corruption. On the other hand, Machine Translation Systems are mostly…

Protein language models (PLMs) have demonstrated remarkable capabilities in learning relationships between protein sequences and functions. However, finetuning these large models requires substantial computational resources, often with…

Time Series Foundation Models (TSFMs) advance generalization and data efficiency in time series forecasting by unified large-scale pretraining. But TSFMs remain lacking when adapting to specific downstream forecasting tasks for two reasons.…

Modern therapeutic antibody design often involves composing multi-part assemblages of individual functional domains, each of which may be derived from a different source or engineered independently. While these complex formats can expand…

Unsupervised cross-lingual pretraining has achieved strong results in neural machine translation (NMT), by drastically reducing the need for large parallel data. Most approaches adapt masked-language modeling (MLM) to sequence-to-sequence…

Algorithms often have tunable parameters that impact performance metrics such as runtime and solution quality. For many algorithms used in practice, no parameter settings admit meaningful worst-case bounds, so the parameters are made…

Fine-tuning Large Language Models (LLMs) on specific datasets is a common practice to improve performance on target tasks. However, this performance gain often leads to overfitting, where the model becomes too specialized in either the task…

Training on test-time data enables deep learning models to adapt to dynamic environmental changes, enhancing their practical applicability. Online adaptation from source to target domains is promising but it remains highly reliant on the…

Multitask prompted finetuning (MTF) has been shown to help large language models generalize to new tasks in a zero-shot setting, but so far explorations of MTF have focused on English data and models. We apply MTF to the pretrained…