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Causal mediation analysis usually requires strong assumptions, such as ignorability of the mediator, which may not hold in many social and scientific studies. Motivated by a multilevel randomized treatment experiment using functional…

应用统计 · 统计学 2017-07-11 Yi Zhao , Xi Luo

In observational studies, potential unobserved confounding is a major barrier in isolating the average causal effect (ACE). In these scenarios, two main approaches are often used: confounder adjustment for causality (CAC) and instrumental…

统计方法学 · 统计学 2024-11-26 Roy S. Zawadzki , Daniel L. Gillen

Performing causal inference in observational studies requires we assume confounding variables are correctly adjusted for. G-computation methods are often used in these scenarios, with several recent proposals using Bayesian versions of…

统计方法学 · 统计学 2021-10-25 Daniel Daly-Grafstein , Paul Gustafson

For observational studies, we study the sensitivity of causal inference when treatment assignments may depend on unobserved confounders. We develop a loss minimization approach for estimating bounds on the conditional average treatment…

统计方法学 · 统计学 2022-03-11 Steve Yadlowsky , Hongseok Namkoong , Sanjay Basu , John Duchi , Lu Tian

In causal inference, sensitivity models assess how unmeasured confounders could alter causal analyses, but the sensitivity parameter -- which quantifies the degree of unmeasured confounding -- is often difficult to interpret. For this…

统计方法学 · 统计学 2025-09-04 Alec McClean , Zach Branson , Edward H. Kennedy

We explore methods to reduce the impact of unobserved confounders on the causal mediation analysis of high-dimensional mediators with spatially smooth structures, such as brain imaging data. The key approach is to incorporate the latent…

统计方法学 · 统计学 2026-05-29 Yuliang Xu , Shu Yang , Jian Kang

Estimating the effect of intervention from observational data while accounting for confounding variables is a key task in causal inference. Oftentimes, the confounders are unobserved, but we have access to large amounts of additional…

机器学习 · 计算机科学 2022-12-13 Shachi Deshpande , Kaiwen Wang , Dhruv Sreenivas , Zheng Li , Volodymyr Kuleshov

Unmeasured confounding is a key threat to reliable causal inference based on observational studies. Motivated from two powerful natural experiment devices, the instrumental variables and difference-in-differences, we propose a new method…

统计方法学 · 统计学 2021-11-09 Ting Ye , Ashkan Ertefaie , James Flory , Sean Hennessy , Dylan S. Small

Plausible identification of conditional average treatment effects (CATEs) may rely on controlling for a large number of variables to account for confounding factors. In these high-dimensional settings, estimation of the CATE requires…

计量经济学 · 经济学 2023-01-18 Adam Baybutt , Manu Navjeevan

We study the problem of learning conditional average treatment effects (CATE) from observational data with unobserved confounders. The CATE function maps baseline covariates to individual causal effect predictions and is key for…

机器学习 · 统计学 2018-10-09 Nathan Kallus , Xiaojie Mao , Angela Zhou

Valid estimation of treatment effects from observational data requires proper control of confounding. If the number of covariates is large relative to the number of observations, then controlling for all available covariates is infeasible.…

统计方法学 · 统计学 2018-01-11 Joseph Antonelli , Matthew Cefalu , Nathan Palmer , Denis Agniel

We consider a causal effect that is confounded by an unobserved variable, but with observed proxy variables of the confounder. We show that, with at least two independent proxy variables satisfying a certain rank condition, the causal…

统计方法学 · 统计学 2018-06-29 Wang Miao , Zhi Geng , Eric Tchetgen Tchetgen

We consider the estimation of average treatment effects in observational studies and propose a new framework of robust causal inference with unobserved confounders. Our approach is based on distributionally robust optimization and proceeds…

统计方法学 · 统计学 2023-02-06 Dimitris Bertsimas , Kosuke Imai , Michael Lingzhi Li

The assumption of no unmeasured confounders is a critical but unverifiable assumption required for causal inference yet quantitative sensitivity analyses to assess robustness of real-world evidence remains underutilized. The lack of use is…

We propose a new Bayesian non-parametric (BNP) method for estimating the causal effects of mediation in the presence of a post-treatment confounder. We specify an enriched Dirichlet process mixture (EDPM) to model the joint distribution of…

统计方法学 · 统计学 2023-05-10 Woojung Bae , Michael J. Daniels , Michael G. Perri

How can we understand classification decisions made by deep neural networks? Many existing explainability methods rely solely on correlations and fail to account for confounding, which may result in potentially misleading explanations. To…

机器学习 · 计算机科学 2020-03-02 Yash Goyal , Amir Feder , Uri Shalit , Been Kim

Causal inference of exact individual treatment outcomes in the presence of hidden confounders is rarely possible. Recent work has extended prediction intervals with finite-sample guarantees to partially identifiable causal outcomes, by…

机器学习 · 计算机科学 2023-11-02 Myrl G. Marmarelis , Greg Ver Steeg , Aram Galstyan , Fred Morstatter

Proximal causal inference (PCI) is a recently proposed framework to identify and estimate the causal effect of an exposure on an outcome in the presence of hidden confounders, using observed proxies. Specifically, PCI relies on two types of…

统计方法学 · 统计学 2025-07-29 Prabrisha Rakshit , Xu Shi , Eric Tchetgen Tchetgen

The presence of intermediate confounders, also called recanting witnesses, is a fundamental challenge to the investigation of causal mechanisms in mediation analysis, preventing the identification of natural path-specific effects. Proposed…

统计方法学 · 统计学 2024-01-10 Tat-Thang Vo , Nicholas Williams , Richard Liu , Kara E. Rudolph , Ivan Dıaz

Random-effects meta-analyses of observational studies can produce biased estimates if the synthesized studies are subject to unmeasured confounding. We propose sensitivity analyses quantifying the extent to which unmeasured confounding of…

统计方法学 · 统计学 2017-10-10 Maya B. Mathur , Tyler J. VanderWeele