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Large pretrained models are showing increasingly better performance in reasoning and planning tasks across different modalities, opening the possibility to leverage them for complex sequential decision making problems. In this paper, we…

人工智能 · 计算机科学 2024-10-10 Martin Klissarov , Devon Hjelm , Alexander Toshev , Bogdan Mazoure

Large language models (LLMs) have recently shown impressive performance on tasks involving reasoning, leading to a lively debate on whether these models possess reasoning capabilities similar to humans. However, despite these successes, the…

计算与语言 · 计算机科学 2024-08-07 Philipp Mondorf , Barbara Plank

In recent years, large pre-trained language models (LLMs) have demonstrated the ability to follow instructions and perform novel tasks from a few examples. The possibility to parameterise an LLM through such in-context examples widens their…

The problem of RNA secondary structure design (also called inverse folding) is the following: given a target secondary structure, one aims to create a sequence that folds into, or is compatible with, a given structure. In several practical…

定量方法 · 定量生物学 2013-08-02 Yu Zhou , Yann Ponty , Stéphane Vialette , Jérôme Waldispühl , Yi Zhang , Alain Denise

We present a reality check on large language models and inspect the promise of retrieval augmented language models in comparison. Such language models are semi-parametric, where models integrate model parameters and knowledge from external…

计算与语言 · 计算机科学 2023-06-05 Wang-Chiew Tan , Yuliang Li , Pedro Rodriguez , Richard James , Xi Victoria Lin , Alon Halevy , Scott Yih

Recent advancements in large language models (LLMs) hold significant promise in improving physics education research that uses machine learning. In this study, we compare the application of various models to perform large-scale analysis of…

物理教育 · 物理学 2025-02-25 Rebeckah K. Fussell , Megan Flynn , Anil Damle , Michael F. J. Fox , N. G. Holmes

Machine learning can provide deep insights into data, allowing machines to make high-quality predictions and having been widely used in real-world applications, such as text mining, visual classification, and recommender systems. However,…

机器学习 · 计算机科学 2020-08-11 Meng Wang , Weijie Fu , Xiangnan He , Shijie Hao , Xindong Wu

RNA secondary structure is modeled with the novel arbitrary-order hidden Markov model ({\alpha}-HMM). The {\alpha}-HMM extends over the traditional HMM with capability to model stochastic events that may be in influenced by historically…

生物大分子 · 定量生物学 2024-01-09 Sixiang Zhang , Aaron J. Yang , Liming Cai

The rapid evolution of large language models (LLMs) has opened new possibilities for automating various tasks in software development. This paper evaluates the capabilities of the Llama 2-70B model in automating these tasks for scientific…

软件工程 · 计算机科学 2025-07-09 Patrick Diehl , Nojoud Nader , Maxim Moraru , Steven R. Brandt

Large Language Models (LLMs) have been shown to encode clinical knowledge. Many evaluations, however, rely on structured question-answer benchmarks, overlooking critical challenges of interpreting and reasoning about unstructured clinical…

计算与语言 · 计算机科学 2026-04-01 Meghal Dani , Muthu Jeyanthi Prakash , Filip Rosa , Zeynep Akata , Stefanie Liebe

At the intersection of the rapidly growing biological data landscape and advancements in Natural Language Processing (NLP), protein language models (PLMs) have emerged as a transformative force in modern research. These models have achieved…

生物大分子 · 定量生物学 2025-02-12 Lei Wang , Xudong Li , Han Zhang , Jinyi Wang , Dingkang Jiang , Zhidong Xue , Yan Wang

Large Language Models (LLMs) have revolutionized the field of Natural Language Processing thanks to their ability to reuse knowledge acquired on massive text corpora on a wide variety of downstream tasks, with minimal (if any) tuning steps.…

计算与语言 · 计算机科学 2024-07-12 Flavio Petruzzellis , Alberto Testolin , Alessandro Sperduti

This systematic literature review comprehensively examines the application of Large Language Models (LLMs) in forecasting and anomaly detection, highlighting the current state of research, inherent challenges, and prospective future…

机器学习 · 计算机科学 2024-02-19 Jing Su , Chufeng Jiang , Xin Jin , Yuxin Qiao , Tingsong Xiao , Hongda Ma , Rong Wei , Zhi Jing , Jiajun Xu , Junhong Lin

Recent work exploring the capabilities of pre-trained large language models (LLMs) has demonstrated their ability to act as general pattern machines by completing complex token sequences representing a wide array of tasks, including…

计算机与社会 · 计算机科学 2024-03-25 Seyed Parsa Neshaei , Richard Lee Davis , Adam Hazimeh , Bojan Lazarevski , Pierre Dillenbourg , Tanja Käser

Large Language Models(LLMs)have become effective tools for natural language processing and have been used in many different fields. This essay offers a succinct summary of various LLM subcategories. The survey emphasizes recent developments…

计算与语言 · 计算机科学 2023-07-21 Saurabh Pahune , Manoj Chandrasekharan

Long non-coding RNA, microRNA, and messenger RNA enable key regulations of various biological processes through a variety of diverse interaction mechanisms. Identifying the interactions and cross-talk between these heterogeneous RNA classes…

分子网络 · 定量生物学 2020-12-10 Nhat Tran , Jean Gao

Automated molecular structure elucidation remains challenging, as existing approaches often depend on pre-compiled databases or restrict themselves to single spectroscopic modalities. Here we introduce SpectraLLM, a large language model…

定量方法 · 定量生物学 2026-05-12 Yunyue Su , Jiahui Chen , Zao Jiang , Zhenyi Zhong , Liang Wang , Qiang Liu , Zhaoxiang Zhang

Accurate survival prediction in radiotherapy (RT) is critical for optimizing treatment decisions. This study developed and validated the RT-Surv framework, which integrates general-domain, open-source large language models (LLMs) to…

Large language models (LLMs) have been widely employed across various application domains, yet their black-box nature poses significant challenges to understanding how these models process input data internally to make predictions. In this…

机器学习 · 计算机科学 2025-09-03 Hangfeng He , Weijie J. Su

Binary code analysis plays a pivotal role in the field of software security and is widely used in tasks such as software maintenance, malware detection, software vulnerability discovery, patch analysis, etc. However, unlike source code,…

软件工程 · 计算机科学 2025-05-01 Xiuwei Shang , Zhenkan Fu , Shaoyin Cheng , Guoqiang Chen , Gangyang Li , Li Hu , Weiming Zhang , Nenghai Yu
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