相关论文: FLASH-enabled Proton SBRT for a challenging case o…
Background: FLASH radiation therapy (FLASH-RT) uses ultra-high dose rates to induce the FLASH effect, enhancing normal tissue sparing. In proton Bragg peak FLASH-RT, this effect is confined to high-dose regions near the target at deep…
Advanced radiotherapy approaches such as FLASH irradiation and spatially fractionated radiotherapy (SFRT) show potential to improve the therapeutic ratio, yet their biological mechanisms and optimal delivery parameters remain uncertain.…
Objective: While FLASH radiotherapy is recognized for short-term normal tissue sparing, its durability in late-responding organs remains uncertain, limiting clinical adoption. With its clinical importance and steep dose-response, the spinal…
We investigated the effects of scanning speed, beam configuration, and dose-rate modeling on the FLASH effect in post-mastectomy proton transmission-beam (TB) planning and evaluated whether optimizing the spot-scanning path can enhance…
We previously developed a FLASH planning framework for streamlined pin-ridge-filter (pin-RF) design, demonstrating its feasibility for single-energy proton FLASH planning. In this study, we refined the pin-RF design for easy assembly using…
FLASH radiotherapy (FLASH-RT) is a new modality of radiotherapy by delivering doses with ultra-high dose rates. FLASH-RT has the ability to suppress tumor growth while sparing normal tissues, known as the FLASH effect. Although FLASH effect…
Purpose: The FLASH effect, which reduces the radiosensitivity of healthy tissue while maintaining tumor control at high dose rates, has shown potential for improving radiation therapy. Conformal FLASH proton therapy involves advanced…
FLASH radiotherapy (FLASH-RT) achieves tumor control comparable to conventional dose-rate irradiation (CONV-RT) while significantly reducing radiation damage to normal tissues. However, the physical conditions triggering the FLASH sparing…
Recently, shoot-through proton FLASH has been proposed where the highest energy is extracted from the cyclotron to maximize the dose rate (DR). Even though our proton pencil beam scanning system can deliver 250 MeV (the highest energy), it…
Purpose: This study explored the feasibility of a streamlined pin-shaped ridge filter (pin-RF) design for single-energy proton FLASH planning. Methods: An inverse planning framework integrated within a TPS was established for FLASH…
Purpose: The purpose of this work was to provide a flexible platform for FLASH research with protons by adapting a former clinical pencil beam scanning gantry to irradiations with ultrahigh dose rates. Methods: PSI Gantry 1 treated patients…
In this paper, we proposed a method to optimize adaptive proton FLASH therapy (ADP FLASH) using modularized pin ridge filters (pRFs) by recycling module pins from the initial plan while reducing pRF adjustments in adaptive FLASH planning.…
FLASH is a new treatment modality that requires optimization of dose, dose rate, and LET. Here we validate these three quantities under FLASH conditions, which includes the quantum uncertainty in the time-dependent instantaneous dose rate…
Background and Objective: Recent experimental studies using ultra-high dose rate radiation therapy (FLASH-RT) have shown improved normal tissue sparing and comparable tumor control compared to conventional dose rate RT. Pencil beam scanning…
Recent results from animal irradiation studies have rekindled interest in the potential of ultra-high dose rate irradiation (also known as FLASH) for reducing normal tissue toxicity. However, despite mounting evidence of a "FLASH effect", a…
FLASH radiation therapy calls for the delivery of fast bursted spills of particles with dose delivery times of the order of milliseconds. The requirements overlap with fundamental physics experimental requests that are being studied at…
Objective: This study aims to investigate the influence of organ architecture (specifically the distinction between serial and parallel tissue) on the protective FLASH effect when organs are irradiated with inhomogeneous dose distributions.…
Purpose: Recent studies suggest ultra-high dose rate (FLASH) irradiation can spare normal tissues from radiotoxicity, while efficiently controlling the tumor, and this is known as the FLASH effect. This study performed theoretical analyses…
Background: Ultra-high-dose-rate (UHDR) radiation therapy has demonstrated promising potential in reducing toxicity to organs-at-risk (OARs). Proton therapy is uniquely positioned to deliver UHDR by leveraging the Bragg peak in conjunction…
The advent of ultra-high dose rate irradiation, known as FLASH radiation therapy, has shown promising potential in reducing toxicity while maintaining tumor control. However, the clinical translation of these benefits necessitates efficient…