相关论文: Unified Representation of Genomic and Biomedical C…

As digital medical imaging becomes more prevalent and archives increase in size, representation learning exposes an interesting opportunity for enhanced medical decision support systems. On the other hand, medical imaging data is often…

Graphs are a central representation in biomedical research, capturing molecular interaction networks, gene regulatory circuits, cell--cell communication maps, and knowledge graphs. Despite their importance, currently there is not a broadly…

Binary concepts are empirically used by humans to generalize efficiently. And they are based on Bernoulli distribution which is the building block of information. These concepts span both low-level and high-level features such as "large vs…

With the rise of generative paradigms, generative recommendation has garnered increasing attention. The core component is the item code, generally derived by quantizing collaborative or semantic representations to serve as candidate items…

Understanding how the brain encodes stimuli has been a fundamental problem in computational neuroscience. Insights into this problem have led to the design and development of artificial neural networks that learn representations by…

The inference of gene regulatory networks (GRNs) is a foundational stride towards deciphering the fundamentals of complex biological systems. Inferring a possible regulatory link between two genes can be formulated as a link prediction…

Word-vector representations associate a high dimensional real-vector to every word from a corpus. Recently, neural-network based methods have been proposed for learning this representation from large corpora. This type of word-to-vector…

Heterogeneous molecular entities and their interactions, commonly depicted as a network, are crucial for advancing our systems-level understanding of biology. With recent advancements in high-throughput data generation and a significant…

Predicting patient features from single-cell data can help identify cellular states implicated in health and disease. Linear models and average cell type expressions are typically favored for this task for their efficiency and robustness,…

Generative retrieval is an emerging approach in information retrieval that generates identifiers (IDs) of target data based on a query, providing an efficient alternative to traditional embedding-based retrieval methods. However, existing…

Motivation: State-of-the-art biomedical named entity recognition (BioNER) systems often require handcrafted features specific to each entity type, such as genes, chemicals and diseases. Although recent studies explored using neural network…

Large language models (LLMs) trained on text demonstrated remarkable results on natural language processing (NLP) tasks. These models have been adapted to decipher the language of DNA, where sequences of nucleotides act as "words" that…

In the genomic era, the identification of gene signatures associated with disease is of significant interest. Such signatures are often used to predict clinical outcomes in new patients and aid clinical decision-making. However, recent…

While deep learning has achieved great success in many fields, one common criticism about deep learning is its lack of interpretability. In most cases, the hidden units in a deep neural network do not have a clear semantic meaning or…

Deep learning models have demonstrated remarkable results for various computer vision tasks, including the realm of medical imaging. However, their application in the medical domain is limited due to the requirement for large amounts of…

Extracting detailed clinical information from free-text medical narratives remains a practical challenge for researchers and healthcare systems. Terminology for immune-mediated and infectious diseases is especially inconsistent across…

Continual learning is essential for medical image classification systems to adapt to dynamically evolving clinical environments. The integration of multimodal information can significantly enhance continual learning of image classes.…

The recent advancement of pre-trained Transformer models has propelled the development of effective text mining models across various biomedical tasks. However, these models are primarily learned on the textual data and often lack the…

BACKGROUND: In this study, we investigated the efficacy of current state-of-the-art neural sentence embedding models for semantic similarity estimation of sentences from biomedical literature. We trained different neural embedding models on…

Drug discovery is a complex process that involves multiple stages and tasks. However, existing molecular generative models can only tackle some of these tasks. We present Generalist Molecular generative model (GenMol), a versatile framework…