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Many experiments in biological and medical sciences currently use multiphoton microscopy as a core imaging technique. To date, solid-state lasers are most commonly used as excitation beam sources. However, the most demanding applications…
Two-photon microscopy (TPM) enables deep tissue imaging but requires excitation pulses that have a large product of average and peak power, typically supplied by femtosecond solid-state lasers. However, these lasers are bulky and…
Multiphoton microscopy has enabled us to image cellular dynamics in vivo. However, the excitation wavelength for imaging with commercially available lasers is mostly limited between 650-1040 nm. Here we develop a femtosecond fiber laser…
In this work we demonstrate 3D imaging using two-photon excitation through a 20 cm long multimode optical fiber (MMF) of 350 micrometers diameter. The imaging principle is similar to single photon fluorescence through a MMF, except that a…
Multiphoton microscopes employ femtosecond lasers as light sources because the high peak power of the ultrashort pulse allows for multiphoton excitation of fluorescence in the examined sample. However, such short pulses are susceptible to…
Two-Photon Microscopy (TPM) can provide three-dimensional morphological and functional contrast in vivo. Through proper staining, TPM can be utilized to create virtual, H&E equivalent images and thus can improve throughput in…
We present an entirely fiber based laser source for non-linear imaging with a novel approach for multi-color excitation. The high power output of an actively modulated and amplified picosecond fiber laser at 1064 nm is shifted to longer…
We demonstrate a fibre-based approach that generates mid-infrared femtosecond pulses in the 3-4 {\mu}m spectral region with microjoule-level single pulse energy. This is realised in a piece of gas-filled antiresonant hollow-core fibre that…
Two-photon excited fluorescence (TPEF) microscopy and fluorescence lifetime imaging (FLIM) are powerful imaging techniques in bio-molecular science. The need for elaborate light sources for TPEF and speed limitations for FLIM, however,…
We report the flexible on-target delivery of 800 nm wavelength, 5 GW peak power, 40 fs duration laser pulses through an evacuated and tightly coiled 10 m long hollow-core nested anti-resonant fiber by positively chirping the input pulses to…
Ultrafast laser pulses that are both tunable in wavelength and very short in duration are essential tools in fields ranging from biomedical imaging to ultrafast spectroscopy. While resonant dispersive-wave emission in gas-filled hollow-core…
Multi-photon microscopy is a powerful tool in biomolecular research. Less complex and more cost effective excitation light sources will make this technique accessible to a broader community. Especially semiconductor diode seeded fiber…
Integrated femtosecond pulse and frequency comb sources are critical components for a wide range of applications. The leading approaches for on-chip pulse generation rely on mode locking inside microresonator with either third-order…
A femtosecond frequency-doubled Erbium-doped fiber laser with adjustable pulse repetition rate is developed and applied in two-photon excited fluorescence microscopy. The all-fiber laser system provides the fundamental pulse at 1560 nm…
Detection and identification of lipids are highly coveted for the interrogation of chronic diseases such as atherosclerosis and myocardial infarction. Intravascular photoacoustic imaging (IVPA) and deep tissue imaging are modern techniques,…
We describe a fiber Raman amplifier for nanosecond and sub-nanosecond pulses centered around 1260 nm. The amplification takes place inside a 4.5-m-long polarization-maintaining phosphorus-doped fiber, pumped at 1080 nm by 3-ns-long pulses…
Multiphoton microscopy is widely used for live imaging. However, its acquisition speed remains limited by fluorophore emission rates and photodamage. To increase the pixel rate of a two-photon microscope beyond a few megahertz (MHz),…
We report design of a tapered fiber that can be used for compression of pulses at different central wavelengths. The proposed fiber is a 3-layer W-type large-mode-area fiber, which has been tapered to transform the mode area from 1700…
We introduce a new scheme for generating short-wavelength coherent broadband radiation with well-controlled spectral characteristics. It is based on shaping long-wavelength femtosecond pulse to coherently control atomic resonance-mediated…
An on-demand single photon source is a key element in a series of prospective quantum technologies and applications. We demonstrate the operation of a tuneable on-demand microwave photon source based on a fully controllable superconducting…