相关论文: Protein-Mamba: Biological Mamba Models for Protein…

Knowing the location of a protein within the cell is important for understanding its function, role in biological processes, and potential use as a drug target. Much progress has been made in developing computational methods that predict…

Predicting the biophysical and functional properties of proteins is essential for in silico protein design. Machine learning has emerged as a promising technique for such prediction tasks. However, the relative scarcity of in vitro…

Forecasting CPU performance, which involves estimating performance scores based on hardware characteristics during operation, is crucial for computational system design and resource management. This research field currently faces two…

In this effort, we propose using the Mamba for handling tabular data in personalized recommendation systems. We present the \textit{FT-Mamba} (Feature Tokenizer\,$+$\,Mamba), a novel hybrid model that replaces Transformer layers with Mamba…

Pretraining DNA language models (DNALMs) on the full human genome is resource-intensive, yet often considered necessary for strong downstream performance. Inspired by recent findings in NLP and long-context modeling, we explore an…

The identification of compound-protein interactions (CPI) plays a critical role in drug screening, drug repurposing, and combination therapy studies. The effectiveness of CPI prediction relies heavily on the features extracted from both…

The Mamba-based model has demonstrated outstanding performance across tasks in computer vision, natural language processing, and speech processing. However, in the realm of speech processing, the Mamba-based model's performance varies…

Depression is a prevalent mental health disorder that severely impairs daily functioning and quality of life. While recent deep learning approaches for depression detection have shown promise, most rely on limited feature types, overlook…

Video understanding requires the extraction of rich spatio-temporal representations, which transformer models achieve through self-attention. Unfortunately, self-attention poses a computational burden. In NLP, Mamba has surfaced as an…

Human activity recognition (HAR) from inertial sensors is essential for ubiquitous computing, mobile health, and ambient intelligence. Conventional deep models such as Convolutional Neural Networks (CNNs), Recurrent Neural Networks (RNNs),…

Predicting accurate protein-ligand binding affinity is important in drug discovery but remains a challenge even with computationally expensive biophysics-based energy scoring methods and state-of-the-art deep learning approaches. Despite…

Directed evolution plays an indispensable role in protein engineering that revises existing protein sequences to attain new or enhanced functions. Accurately predicting the effects of protein variants necessitates an in-depth understanding…

Proteins are essential biological macromolecules that execute life functions. Local structural motifs, such as active sites, are the most critical components for linking structure to function and are key to understanding protein evolution…

Protein representation learning plays a crucial role in understanding the structure and function of proteins, which are essential biomolecules involved in various biological processes. In recent years, deep learning has emerged as a…

While the Mamba architecture demonstrates superior inference efficiency and competitive performance on short-context natural language processing (NLP) tasks, empirical evidence suggests its capacity to comprehend long contexts is limited…

Current pharmaceutical formulation development still strongly relies on the traditional trial-and-error approach by individual experiences of pharmaceutical scientists, which is laborious, time-consuming and costly. Recently, deep learning…

Proteins are sequences of amino acids that serve as the basic building blocks of living organisms. Despite rapidly growing databases documenting structural and functional information for various protein sequences, our understanding of…

Image generation models have encountered challenges related to scalability and quadratic complexity, primarily due to the reliance on Transformer-based backbones. In this study, we introduce MaskMamba, a novel hybrid model that combines…

Accurate prediction of protein-ligand binding affinities is crucial for drug development. Recent advances in machine learning show promising results on this task. However, these methods typically rely heavily on labeled data, which can be…

Protein-protein interactions drive many biological processes, including the detection of phytopathogens by plants' R-Proteins and cell surface receptors. Many machine learning studies have attempted to predict protein-protein interactions…