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Multiple Instance Learning (MIL) methods allow for gigapixel Whole-Slide Image (WSI) analysis with only slide-level annotations. Interpretability is crucial for safely deploying such algorithms in high-stakes medical domains. Traditional…

计算机视觉与模式识别 · 计算机科学 2025-01-07 Susu Sun , Leslie Tessier , Frédérique Meeuwsen , Clément Grisi , Dominique van Midden , Geert Litjens , Christian F. Baumgartner

Multiple instance learning (MIL)-based framework has become the mainstream for processing the whole slide image (WSI) with giga-pixel size and hierarchical image context in digital pathology. However, these methods heavily depend on a…

计算机视觉与模式识别 · 计算机科学 2025-02-13 Jiangbo Shi , Chen Li , Tieliang Gong , Yefeng Zheng , Huazhu Fu

Radiologists must utilize multiple modal images for tumor segmentation and diagnosis due to the limitations of medical imaging and the diversity of tumor signals. This leads to the development of multimodal learning in segmentation.…

计算机视觉与模式识别 · 计算机科学 2024-07-11 Chuyun Shen , Wenhao Li , Haoqing Chen , Xiaoling Wang , Fengping Zhu , Yuxin Li , Xiangfeng Wang , Bo Jin

Multi-instance learning (MIL) is a form of weakly supervised learning where a single class label is assigned to a bag of instances while the instance-level labels are not available. Training classifiers to accurately determine the bag label…

计算机视觉与模式识别 · 计算机科学 2020-06-11 Bin Li , Kevin W. Eliceiri

Convolutional neural networks (CNNs) and transformers are widely employed in constructing UNet architectures for medical image segmentation tasks. However, CNNs struggle to model long-range dependencies, while transformers suffer from…

图像与视频处理 · 电气工程与系统科学 2025-03-26 Shaolei Zhang , Jinyan Liu , Tianyi Qian , Xuesong Li

In computational pathology, weak supervision has become the standard for deep learning due to the gigapixel scale of WSIs and the scarcity of pixel-level annotations, with Multiple Instance Learning (MIL) established as the principal…

计算机视觉与模式识别 · 计算机科学 2025-12-17 Andreas Lolos , Theofilos Christodoulou , Aris L. Moustakas , Stergios Christodoulidis , Maria Vakalopoulou

The accelerated MRI reconstruction poses a challenging ill-posed inverse problem due to the significant undersampling in k-space. Deep neural networks, such as CNNs and ViTs, have shown substantial performance improvements for this task…

图像与视频处理 · 电气工程与系统科学 2025-04-01 Yucong Meng , Zhiwei Yang , Zhijian Song , Yonghong Shi

Accurate microscopic medical image segmentation plays a crucial role in diagnosing various cancerous cells and identifying tumors. Driven by advancements in deep learning, convolutional neural networks (CNNs) and transformer-based models…

计算机视觉与模式识别 · 计算机科学 2025-06-17 Daniya Najiha Abdul Kareem , Abdul Hannan , Mubashir Noman , Jean Lahoud , Mustansar Fiaz , Hisham Cholakkal

Multiple Instance Learning (MIL) models have proven effective for cancer prognosis from Whole Slide Images. However, the original MIL formulation incorrectly assumes the patches of the same image to be independent, leading to a loss of…

计算机视觉与模式识别 · 计算机科学 2024-08-13 Thiziri Nait Saada , Valentina Di Proietto , Benoit Schmauch , Katharina Von Loga , Lucas Fidon

Multiple instance learning (MIL) is a supervised learning methodology that aims to allow models to learn instance class labels from bag class labels, where a bag is defined to contain multiple instances. MIL is gaining traction for learning…

计算机视觉与模式识别 · 计算机科学 2019-11-14 Samuel W. Remedios , Zihao Wu , Camilo Bermudez , Cailey I. Kerley , Snehashis Roy , Mayur B. Patel , John A. Butman , Bennett A. Landman , Dzung L. Pham

Brain tumors exhibit high heterogeneity in morphology and multimodal contrast, making manual slice-by-slice de lineation time-consuming and experience-dependent, thus necessitating efficient and stable automated segmentation methods. To…

计算机视觉与模式识别 · 计算机科学 2026-05-19 Hanjun Tao , Hua Wang , Fan Zhang

In data-scarce scenarios, deep learning models often overfit to noise and irrelevant patterns, which limits their ability to generalize to unseen samples. To address these challenges in medical image segmentation, we introduce Diff-UMamba,…

计算机视觉与模式识别 · 计算机科学 2026-04-06 Dhruv Jain , Romain Modzelewski , Romain Herault , Clement Chatelain , Eva Torfeh , Sebastien Thureau

Due to the lack of fine-grained annotation guidance, current Multiple Instance Learning (MIL) struggles to establish a robust causal relationship between Whole Slide Image (WSI) diagnosis and evidence sub-images, just like fully supervised…

计算机视觉与模式识别 · 计算机科学 2025-07-08 Tianhang Nan , Yong Ding , Hao Quan , Deliang Li , Lisha Li , Guanghong Zhao , Xiaoyu Cui

Foundation models (FMs) have transformed computational pathology by providing powerful, general-purpose feature extractors. However, adapting and benchmarking individual FMs for specific diagnostic tasks is often time-consuming and…

计算机视觉与模式识别 · 计算机科学 2025-10-07 Peiran Quan , Zifan Gu , Zhuo Zhao , Qin Zhou , Donghan M. Yang , Ruichen Rong , Yang Xie , Guanghua Xiao

Abnormality detection in medical imaging is a critical task requiring both high efficiency and accuracy to support effective diagnosis. While convolutional neural networks (CNNs) and Transformer-based models are widely used, both face…

计算机视觉与模式识别 · 计算机科学 2025-09-03 Yao Wang , Dong Yang , Zhi Qiao , Wenjian Huang , Liuzhi Yang , Zhen Qian

Multiple instance learning (MIL) is an effective and widely used approach for weakly supervised machine learning. In histopathology, MIL models have achieved remarkable success in tasks like tumor detection, biomarker prediction, and…

Continual Learning (CL) aims to equip AI models with the ability to learn a sequence of tasks over time, without forgetting previously learned knowledge. Recently, State Space Models (SSMs), particularly the Mamba model, have achieved…

计算机视觉与模式识别 · 计算机科学 2025-07-11 De Cheng , Yue Lu , Lingfeng He , Shizhou Zhang , Xi Yang , Nannan Wang , Xinbo Gao

Multi-modality image fusion (MMIF) aims to integrate complementary information from different modalities into a single fused image to represent the imaging scene and facilitate downstream visual tasks comprehensively. In recent years,…

计算机视觉与模式识别 · 计算机科学 2024-04-15 Zhe Li , Haiwei Pan , Kejia Zhang , Yuhua Wang , Fengming Yu

Nuclei panoptic segmentation supports cancer diagnostics by integrating both semantic and instance segmentation of different cell types to analyze overall tissue structure and individual nuclei in histopathology images. Major challenges…

图像与视频处理 · 电气工程与系统科学 2026-01-26 Ming Kang , Fung Fung Ting , Raphaël C. -W. Phan , Zongyuan Ge , Chee-Ming Ting

Convolutional neural networks can be trained to perform histology slide classification using weak annotations with multiple instance learning (MIL). However, given the paucity of labeled histology data, direct application of MIL can easily…

计算机视觉与模式识别 · 计算机科学 2019-11-05 Ming Y. Lu , Richard J. Chen , Jingwen Wang , Debora Dillon , Faisal Mahmood