相关论文: A CRH-HCN Theory of Obsessive-Compulsive Disorder …

This paper presents a complete theory of autism spectrum disorder (ASD), explaining its etiology, symptoms, and pathology. The core cause of ASD is excessive stress-induced postnatal release of corticotropin-releasing hormone (CRH). CRH…

Obsessive-compulsive disorder (OCD) is a common psychiatric disorder with a lifetime prevalence of 2-3 percent. Recently, brain activity in the resting state is gathering attention as a new means of exploring altered functional connectivity…

This paper gives an explanatory framework for obsessive-compulsive disorder (OCD) based on a generative model of cognition. The framework is constructed using the new concept of a 'formal narrative' which is a sequence of cognitive states…

The neuronal circuit that controls obsessive and compulsive behaviors involves a complex network of brain regions (some with known involvement in reward processing). Among these are cortical regions, the striatum and the thalamus (which…

This paper presents a predictive coding account of obsessive-compulsive disorder (OCD). We extend the predictive coding model to include the concept of a 'formal narrative', or temporal sequence of cognitive states inferred from sense data.…

Obsessive-compulsive disorder (OCD) is a mental health condition that significantly impacts people's quality of life. While evidence-based therapies such as exposure and response prevention (ERP) can be effective, managing OCD symptoms in…

Obsessive-compulsive disorder (OCD) presents itself as a highly debilitating disorder. The disorder has common associations with the prefrontal cortex and the glutamate receptor known as Metabotropic Glutamate Receptor 5 (mGluR5). This…

In recent years the importance of Smart Healthcare cannot be overstated. The current work proposed to expand the state-of-art of smart healthcare in integrating solutions for Obsessive Compulsive Disorder (OCD). Identification of OCD from…

Obsessive-Compulsive Disorder (OCD), characterized by unwanted and distressing intrusive thoughts, images, urges, doubts and ideas or sensations and repetitive mental or behavioral acts, which is regarded as an overwhelming mental disorder.…

Major depressive disorder (MDD) is a debilitating health condition affecting a substantial part of the world's population. At present, there is no biological theory of MDD, and treatment is partial at best. Here I present a theory of MDD…

Current theoretical and computational models of dopamine-based reinforcement learning are largely rooted in the classical behaviorist tradition, and envision the organism as a purely reactive recipient of rewards and punishments, with…

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease that causes obstructed airflow from the lungs. In the United States, more than 15.7 million Americans have been diagnosed with COPD, with 96% of individuals…

Visceral theory of sleep states that the same brain neurons, which process external information in wakefulness, during sleep switch to the processing of internal information coming from various visceral systems. Here we hypothesize that a…

Self-organized criticality (SOC) refers to the ability of complex systems to evolve towards a 2nd-order phase transition at which interactions between system components lead to scale-invariant events beneficial for system performance. For…

This work presents a comprehensive theory of consciousness grounded in mathematical formalism and supported by clinical data analysis. The framework developed herein demonstrates that consciousness exists as a continuous, non-monotonic…

The effect of disorder on a class of transition metal oxides described by a single orbital Hubbard model at half filling is investigated. The phases are characterized by the nature of the electronic and spin excitations. The frequency and…

Many natural systems including the brain comprise coupled non-uniformly stimulated elements. In this paper we show that heterogeneously driven networks of excitatory-inhibitory units exhibit striking collective phenomena, including…

Continual learning (CL) is an important technique to allow artificial neural networks to work in open environments. CL enables a system to learn new tasks without severe interference to its performance on old tasks, i.e., overcome the…

Behavioral control over stressful stimuli induces resilience to future conditions when control is lacking. The medial prefrontal cortex(mPFC) is a critically important brain region required for plasticity of stress resilience. We found that…

Structured internal representations (cognitive maps) shape cognition, from imagining the future and counterfactual past, to transferring knowledge to new settings. Our understanding of how such representations are formed and maintained in…