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Durotaxis motion is a spectacular phenomenon manifesting itself by the autonomous motion of a nano-object between parts of a substrate with different stiffness. This motion usually takes place along a stiffness gradient from softer to…

流体动力学 · 物理学 2023-11-07 Russell Kajouri , Panagiotis E. Theodorakis , Jan Židek , Andrey Milchev

Numerous cell-types have shown a remarkable ability to detect and move along gradients in stiffness of an underlying substrate -- a process known as durotaxis. The mechanisms underlying durotaxis are still unresolved, but generally believed…

A range of technologies require the directed motion of nanoscale droplets on solid substrates. A way of realizing this effect is durotaxis, whereby a stiffness gradient of a substrate can induce directional motion without requiring an…

软凝聚态物质 · 物理学 2018-05-23 P. E. Theodorakis , S. A. Egorov , A. Milchev

Applications such as digital microfluidics and bio-diagnostics rely on droplet locomotion. A prominent example of such motion is durotaxis, a phenomenon that requires a stiffness gradient along a surface for the transport of liquids, cells,…

流体动力学 · 物理学 2026-04-21 Panagiotis E. Theodorakis , Andrey Milchev

Using extensive molecular dynamics simulation of a coarse-grained model, we demonstrate the possibility of sustained unidirectional motion (durotaxis) of droplets without external energy supply when placed on a polymer brush substrate with…

Fluid droplets can be induced to move over rigid or flexible surfaces under external or body forces. We describe the effect of variations in material properties of a flexible substrate as a mechanism for motion. In this paper, we consider a…

软凝聚态物质 · 物理学 2019-08-27 Aaron Bardall , Shih-Yuan Chen , Karen E. Daniels , Michael Shearer

Most passive droplet transport strategies rely on spatial variations of material properties to drive droplet motion, leading to gradient-based mechanisms with intrinsic length scales that limit the droplet velocity or the transport…

流体动力学 · 物理学 2025-12-01 Sthavishtha R. Bhopalam , Jesus Bueno , Hector Gomez

Cells move differently on substrates with different elasticities. In particular, the persistence time of their motion is higher on stiffer substrates. We show that this behavior will result in a net transport of cells directed up a…

生物物理 · 物理学 2017-03-09 Elizaveta A. Novikova , Matthew Raab , Dennis E. Discher , Cornelis Storm

Earlier works found out spontaneous directional motion of liquid droplets on hydrophilic conical surfaces, however, not hydrophobic case. Here we show that droplets on any surface may take place spontaneous directional motion without…

化学物理 · 物理学 2011-01-21 Cunjing Lv , Chao Chen , Yajun Yin , Fan-gang Tseng , Quanshui Zheng

We demonstrate spontaneous bidirectional motion of droplets on liquid infused surfaces in the presence of a topographical gradient, in which the droplets can move either toward the denser or the sparser solid fraction area. Our analytical…

We report an experimental investigation of the spontaneous motion of liquid droplets on soft gels with a crosslinking gradient. By systematically adjusting the spatial difference in crosslinking density, we observed that millimeter-sized…

软凝聚态物质 · 物理学 2025-01-29 Weiwei Zhao , Wenjie Qian , Chang Xu , Qin Xu

The transport of small quantities of liquid on a solid surface is inhibited by the resistance to motion caused by the contact between the liquid and the solid. To overcome such resistance, motion can be externally driven through gradients…

Droplet motion over a surface with wettability gradient has been simulated using molecular dynamics (MD) simulation to highlight the underlying physics. GROMACS and Visual Molecular Dynamics (VMD) were used for simulation and intermittent…

流体动力学 · 物理学 2015-04-13 Monojit Chakraborty , Anamika Chowdhury , Richa Bhusan , Sunando DasGupta

Nano-patterned substrates offer possibilities for controlling the motion of fluids without external energy supply in novel technologies in microfluidics, coatings, etc. Here, we report on the rugotaxial motion of droplets on wrinkled…

流体动力学 · 物理学 2023-06-26 Panagiotis E. Theodorakis , Sergei A. Egorov , Andrey Milchev

How to make small liquid droplets move spontaneously and directionally on solid surfaces is a challenge in lab-on-chip technologies, DNA analysis, and heat exchangers. The best-known mechanism, a wettability gradient, does not move droplets…

流体动力学 · 物理学 2015-03-13 Cunjing Lv , Chao Chen , Yin-Chuan Chuang , Fan-Gang Tseng , Yajun Yin , Francois Grey , Quanshui Zheng

Making liquid droplets move spontaneously on solid surfaces is a key challenge in lab-on-chip and heat exchanger technologies. The best-known mechanism, a wettability gradient, does not generally move droplets rapidly enough and cannot…

软凝聚态物质 · 物理学 2015-03-13 Cunjing Lv , Chao Chen , Yin-Chuan Chuang , Fan-Gang Tseng , Yajun Yin , Francois Grey , Quanshui Zheng

We study chemically driven running droplets on a partially wetting solid substrate by means of coupled evolution equations for the thickness profile of the droplets and the density profile of an adsorbate layer. Two models are introduced…

软凝聚态物质 · 物理学 2007-05-23 K. John , M. Baer , U. Thiele

We demonstrate \textit{bendotaxis}, a novel mechanism for droplet self-transport at small scales. A combination of bending and capillarity in a thin channel causes a pressure gradient that, in turn, results in the spontaneous movement of a…

软凝聚态物质 · 物理学 2019-03-12 Alexander T. Bradley , Finn Box , Ian J. Hewitt , Dominic Vella

Biological cells are able to adapt their behaviour in response to environmental cues. Durotaxis is a phenomenon in which cells adjust their migration depending on the mechanical properties of a surrounding substrate. Although durotaxis has…

生物物理 · 物理学 2026-05-11 Sohei Nakamura , Mitsusuke Tarama

Motile biological cells in tissue often display the phenomenon of durotaxis, i.e. they tend to move towards stiffer parts of substrate tissue. The mechanism for this behavior is not completely understood. We consider simplified models for…

生物物理 · 物理学 2019-01-03 Charles R. Doering , Xiaoming Mao , Leonard M. Sander
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