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Matching cancer patients to clinical trials is essential for advancing treatment and patient care. However, the inconsistent format of medical free text documents and complex trial eligibility criteria make this process extremely…

In this paper, we demonstrate a surprising capability of large language models (LLMs): given only input feature names and a description of a prediction task, they are capable of selecting the most predictive features, with performance…

机器学习 · 计算机科学 2025-04-21 Daniel P. Jeong , Zachary C. Lipton , Pradeep Ravikumar

Clinical trial matching is a key process in health delivery and discovery. In practice, it is plagued by overwhelming unstructured data and unscalable manual processing. In this paper, we conduct a systematic study on scaling clinical trial…

Large language models (LLMs) are being explored for diagnostic decision support, yet their ability to estimate pre-test probabilities, vital for clinical decision-making, remains limited. This study evaluates two LLMs, Mistral-7B and…

We investigate the predictability of large language model (LLM) capabilities: given records of past experiments using different model families, numbers of parameters, tasks, and numbers of in-context examples, can we accurately predict LLM…

计算与语言 · 计算机科学 2023-11-01 Qinyuan Ye , Harvey Yiyun Fu , Xiang Ren , Robin Jia

Large language models (LLMs) have demonstrated remarkable capabilities in natural language understanding and generation across various domains, including medicine. We present a comprehensive evaluation of GPT-4, a state-of-the-art LLM, on…

计算与语言 · 计算机科学 2023-04-13 Harsha Nori , Nicholas King , Scott Mayer McKinney , Dean Carignan , Eric Horvitz

Large language models (LLMs) show promise for supporting clinical decision-making in complex fields such as rheumatology. Our evaluation shows that smaller language models (SLMs), combined with retrieval-augmented generation (RAG), achieve…

Recent work has investigated the capabilities of large language models (LLMs) as zero-shot models for generating individual-level characteristics (e.g., to serve as risk models or augment survey datasets). However, when should a user have…

Advances in large language models (LLMs) have empowered a variety of applications. However, there is still a significant gap in research when it comes to understanding and enhancing the capabilities of LLMs in the field of mental health. In…

计算与语言 · 计算机科学 2024-01-30 Xuhai Xu , Bingsheng Yao , Yuanzhe Dong , Saadia Gabriel , Hong Yu , James Hendler , Marzyeh Ghassemi , Anind K. Dey , Dakuo Wang

Large language models (LLMs) have demonstrated impressive performance across various domains. However, for clinical diagnosis, higher expectations are required for LLM's reliability and sensitivity: thinking like physicians and remaining…

计算与语言 · 计算机科学 2025-04-21 Chenwei Yan , Xiangling Fu , Yuxuan Xiong , Tianyi Wang , Siu Cheung Hui , Ji Wu , Xien Liu

According to GHO (Global Health Observatory (GHO), the high prevalence of a large variety of diseases such as Ischaemic heart disease, stroke, lung cancer disease and lower respiratory infections have remained the top killers during the…

人工智能 · 计算机科学 2020-09-17 Mayssa Ben Kahla , Dalel Kanzari , Ahmed Maalel

Machine learning practitioners often face significant challenges in formally integrating their prior knowledge and beliefs into predictive models, limiting the potential for nuanced and context-aware analyses. Moreover, the expertise needed…

机器学习 · 统计学 2024-12-23 James Requeima , John Bronskill , Dami Choi , Richard E. Turner , David Duvenaud

Large language models (LLMs) have made significant progress in various domains, including healthcare. However, the specialized nature of clinical language understanding tasks presents unique challenges and limitations that warrant further…

计算与语言 · 计算机科学 2023-08-01 Yuqing Wang , Yun Zhao , Linda Petzold

Accurate risk assessment in lung cancer screening is critical for enabling early cancer detection and minimizing unnecessary invasive procedures. The Lung CT Screening Reporting and Data System (Lung-RADS) has been widely used as the…

机器学习 · 计算机科学 2025-09-09 Chuang Niu , Ge Wang

Lab results are often confusing and hard to understand. Large language models (LLMs) such as ChatGPT have opened a promising avenue for patients to get their questions answered. We aim to assess the feasibility of using LLMs to generate…

计算与语言 · 计算机科学 2024-04-23 Zhe He , Balu Bhasuran , Qiao Jin , Shubo Tian , Karim Hanna , Cindy Shavor , Lisbeth Garcia Arguello , Patrick Murray , Zhiyong Lu

Prior work has shown that large language models (LLMs) can predict human attitudes based on other attitudes, but this work has largely focused on predictions from highly similar and interrelated attitudes. In contrast, human attitudes are…

计算与语言 · 计算机科学 2025-03-28 Ana Ma , Derek Powell

Cancer clinical trials often face challenges in recruitment and engagement due to a lack of participant-facing informational and educational resources. This study investigated the potential of Large Language Models (LLMs), specifically…

Large Language Models (LLMs) have demonstrated substantial progress in biomedical and clinical applications, motivating rigorous evaluation of their ability to answer nuanced, evidence-based questions. We curate a multi-source benchmark…

计算与语言 · 计算机科学 2025-09-16 Can Wang , Yiqun Chen

Measuring the generalization ability of Large Language Models (LLMs) is challenging due to data contamination. As models grow and computation becomes cheaper, ensuring tasks and test cases are unseen during training phases will become…

计算与语言 · 计算机科学 2025-07-09 Sougata Saha , Monojit Choudhury

Large language models (LLMs) have immense potential to make information more accessible, particularly in medicine, where complex medical jargon can hinder patient comprehension of clinical notes. We developed a patient-facing tool using…