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This study introduces a novel teacher-student architecture utilizing Large Language Models (LLMs) to improve prostate cancer radiotherapy symptom extraction from clinical notes. Mixtral, the student model, initially extracts symptoms,…

Background: The radiation oncology clinical practice involves many steps relying on the dynamic interplay of abundant text data. Large language models have displayed remarkable capabilities in processing complex text information. But their…

The open-endedness of large language models (LLMs) combined with their impressive capabilities may lead to new safety issues when being exploited for malicious use. While recent studies primarily focus on probing toxic outputs that can be…

计算与语言 · 计算机科学 2023-11-30 Jiaxin Wen , Pei Ke , Hao Sun , Zhexin Zhang , Chengfei Li , Jinfeng Bai , Minlie Huang

Large Language Models (LLMs) have shown significant promise across various natural language processing tasks. However, their application in the field of pathology, particularly for extracting meaningful insights from unstructured medical…

计算与语言 · 计算机科学 2025-03-04 Rachit Saluja , Jacob Rosenthal , Yoav Artzi , David J. Pisapia , Benjamin L. Liechty , Mert R. Sabuncu

Natural language processing (NLP) is a key technology to extract important patient information from clinical narratives to support healthcare applications. The rapid development of large language models (LLMs) has revolutionized many NLP…

计算与语言 · 计算机科学 2025-09-08 Cheng Peng , Xinyu Dong , Mengxian Lyu , Daniel Paredes , Yaoyun Zhang , Yonghui Wu

This study presents a systematic comparison of three approaches for the analysis of mental health text using large language models (LLMs): prompt engineering, retrieval augmented generation (RAG), and fine-tuning. Using LLaMA 3, we evaluate…

计算与语言 · 计算机科学 2025-04-01 Arshia Kermani , Veronica Perez-Rosas , Vangelis Metsis

Large language models (LLMs) excel at clinical information extraction but their computational demands limit practical deployment. Knowledge distillation--the process of transferring knowledge from larger to smaller models--offers a…

计算与语言 · 计算机科学 2025-01-03 Karthik S. Vedula , Annika Gupta , Akshay Swaminathan , Ivan Lopez , Suhana Bedi , Nigam H. Shah

This study evaluates the performance of Large Language Models (LLMs) as an Artificial Intelligence-based tutor for a university course. In particular, different advanced techniques are utilized, such as prompt engineering,…

Recent AI agents, such as ChatGPT and LLaMA, primarily rely on instruction tuning and reinforcement learning to calibrate the output of large language models (LLMs) with human intentions, ensuring the outputs are harmless and helpful.…

计算与语言 · 计算机科学 2025-02-14 Jingxin Xu , Guoshun Nan , Sheng Guan , Sicong Leng , Yilian Liu , Zixiao Wang , Yuyang Ma , Zhili Zhou , Yanzhao Hou , Xiaofeng Tao

Patients with diabetes are at increased risk of comorbid depression or anxiety, complicating their management. This study evaluated the performance of large language models (LLMs) in detecting these symptoms from secure patient messages. We…

We evaluated the viability of using a Large Language Model (LLM) to extract patient-specific specific toxicity and progression outcomes from unstructured radiology reports. We retrospectively extracted 160 follow-up CT and PET/CT electronic…

医学物理 · 物理学 2026-03-02 Justin Pijanowski , Yakout Mezgueldi , Alan Lee , Drew Moghanaki , Ricky R. Savjani , James Lamb

Accurately communicating the side effects of cancer treatments to cancer survivors is critical, particularly in settings such as informed consent, where clinicians must clearly and comprehensively convey potential treatment toxicities.…

计算与语言 · 计算机科学 2026-05-19 Natalie Seah , Danielle S. Bitterman , Daphna Spiegel , Thomas Hartvigsen

In this work, we designed unbiased prompts to systematically evaluate the psychological safety of large language models (LLMs). First, we tested five different LLMs by using two personality tests: Short Dark Triad (SD-3) and Big Five…

计算与语言 · 计算机科学 2024-03-01 Xingxuan Li , Yutong Li , Lin Qiu , Shafiq Joty , Lidong Bing

Despite significant progress in applying large language models (LLMs) to the medical domain, several limitations still prevent them from practical applications. Among these are the constraints on model size and the lack of cohort-specific…

人工智能 · 计算机科学 2024-09-26 Yishu Wei , Xindi Wang , Hanley Ong , Yiliang Zhou , Adam Flanders , George Shih , Yifan Peng

Existing approaches for Large language model (LLM) detoxification generally rely on training on large-scale non-toxic or human-annotated preference data, designing prompts to instruct the LLM to generate safe content, or modifying the model…

计算与语言 · 计算机科学 2025-06-03 Yuanhe Tian , Mingjie Deng , Guoqing Jin , Yan Song

Pathology reports serve as the definitive record for breast cancer staging, yet their unstructured format impedes large-scale data curation. While Large Language Models (LLMs) offer semantic reasoning, their deployment is often limited by…

机器学习 · 计算机科学 2026-04-16 Jiahao Shao , Anam Nawaz Khan , Christopher Brett , Tom Berg , Xueping Li , Bing Yao

Although both Google Gemini (1.5 Flash) and ChatGPT (4o and 4o-mini) give research quality evaluation scores that correlate positively with expert scores in nearly all fields, and more strongly that citations in most, it is not known…

数字图书馆 · 计算机科学 2025-08-12 Mike Thelwall

This paper describes a rapid feasibility study of using GPT-4, a large language model (LLM), to (semi)automate data extraction in systematic reviews. Despite the recent surge of interest in LLMs there is still a lack of understanding of how…

Cancer clinical trials often face challenges in recruitment and engagement due to a lack of participant-facing informational and educational resources. This study investigated the potential of Large Language Models (LLMs), specifically…

Extracting structured information from clinical notes requires navigating a dense web of interdependent variables where the value of one attribute logically constrains others. Existing Large Language Model (LLM)-based extraction pipelines…

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