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We present a machine learning pipeline and model that uses the entire uncurated EHR for prediction of in-hospital mortality at arbitrary time intervals, using all available chart, lab and output events, without the need for pre-processing…

机器学习 · 计算机科学 2019-09-18 Jacob Deasy , Pietro Liò , Ari Ercole

Identifying the effects of mechanical ventilation strategies and protocols in critical care requires analyzing data from heterogeneous patient-ventilator systems within the context of the clinical decision-making environment. This research…

Age-specific probabilities of death provide a snapshot of population mortality at the country level at a given point in time. Due to the high dimensionality of the data, summarising mortality information is essential for various analyses,…

应用统计 · 统计学 2026-03-30 Pedro Menezes de Araújo , Isobel Claire Gormley , Thomas Brendan Murphy

To draw real-world evidence about the comparative effectiveness of multiple time-varying treatments on patient survival, we develop a joint marginal structural survival model and a novel weighting strategy to account for time-varying…

统计方法学 · 统计学 2023-08-08 Liangyuan Hu , Jiayi Ji , Himanshu Joshi , Erick Scott , Fan Li

We propose a clustering-based approach for identifying coherent flow structures in continuous dynamical systems. We first treat a particle trajectory over a finite time interval as a high-dimensional data point and then cluster these data…

动力系统 · 数学 2022-12-27 Wai Ming Chau , Shingyu Leung

This paper provides a comprehensive analysis of variational inference in latent variable models for survival analysis, emphasizing the distinctive challenges associated with applying variational methods to survival data. We identify a…

机器学习 · 计算机科学 2025-06-05 Chuanhui Liu , Xiao Wang

Variational Bayes (VB) is a popular scalable alternative to Markov chain Monte Carlo for Bayesian inference. We study a mean-field spike and slab VB approximation of widely used Bayesian model selection priors in sparse high-dimensional…

机器学习 · 统计学 2021-09-07 Kolyan Ray , Botond Szabo , Gabriel Clara

Dynamical phenomena such as infectious diseases are often investigated by following up subjects longitudinally, thus generating time to event data. The spatial aspect of such data is also of primordial importance, as many infectious…

统计方法学 · 统计学 2020-10-13 Ajmal Oodally , Estelle Kuhn , Klara Goethals , Luc Duchateau

Time series analysis of fMRI data is an important area of medical statistics for neuroimaging data. The neuroimaging community has embraced mean-field variational Bayes (VB) approximations, which are implemented in Statistical Parametric…

统计计算 · 统计学 2018-03-06 Ming Teng , Timothy Johnson , Farouk Nathoo

Effective clustering of biomedical data is crucial in precision medicine, enabling accurate stratifiction of patients or samples. However, the growth in availability of high-dimensional categorical data, including `omics data, necessitates…

机器学习 · 统计学 2026-03-03 Jackie Rao , Paul D. W. Kirk

In low-resource settings where vital registration of death is not routine it is often of critical interest to determine and study the cause of death (COD) for individuals and the cause-specific mortality fraction (CSMF) for populations.…

应用统计 · 统计学 2022-07-27 Kelly R. Moran , Elizabeth L. Turner , David Dunson , Amy H. Herring

Cluster-randomized trials (CRTs) on fragile populations frequently encounter complex attrition problems where the reasons for missing outcomes can be heterogeneous, with participants who are known alive, known to have died, or with unknown…

统计方法学 · 统计学 2025-05-06 Guangyu Tong , Chenxi Li , Eric Velazquez , Michael O. Harhay , Fan Li

We propose a new method for clustering of functional data using a $k$-means framework. We work within the elastic functional data analysis framework, which allows for decomposition of the overall variation in functional data into amplitude…

统计方法学 · 统计学 2020-11-26 Xiao Zang , Sebastian Kurtek , Oksana Chkrebtii , J. Derek Tucker

Bayesian approaches to clinical analyses for the purposes of patient phenotyping have been limited by the computational challenges associated with applying the Markov-Chain Monte-Carlo (MCMC) approach to large real-world data. Approximate…

应用统计 · 统计学 2023-03-27 Brian Buckley , Adrian O'Hagan , Marie Galligan

As a statistical tool to assist formative assessments in educational settings, diagnostic classification models (DCMs) have been increasingly used to provide diagnostic information regarding examinees' attributes. DCMs often adopt a…

统计计算 · 统计学 2022-08-24 Motonori Oka , Shun Saso , Kensuke Okada

Variational Bayes (VB) is a popular estimation method for Bayesian inference. However, most existing VB algorithms are restricted to cases where the likelihood is tractable, which precludes their use in many important situations. Tran et…

统计方法学 · 统计学 2017-05-19 David Gunawan , Minh-Ngoc Tran , Robert Kohn

The standard Bayesian technique for searching pulsar timing data for gravitational wave (GW) bursts with memory (BWMs) using Markov Chain Monte Carlo (MCMC) sampling is very computationally expensive to perform. In this paper, we explain…

广义相对论与量子宇宙学 · 物理学 2023-08-02 Jerry Sun , Paul T. Baker , Aaron D. Johnson , Dustin R. Madison , Xavier Siemens

Functional concurrent, or varying-coefficient, regression models are commonly used in biomedical and clinical settings to investigate how the relation between an outcome and observed covariate varies as a function of another covariate. In…

统计方法学 · 统计学 2024-10-10 Mingrui Liang , Matthew D. Koslovsky , Emily T. Hebert , Darla E. Kendzor , Marina Vannucci

Many probabilistic models of interest in scientific computing and machine learning have expensive, black-box likelihoods that prevent the application of standard techniques for Bayesian inference, such as MCMC, which would require access to…

机器学习 · 统计学 2018-11-30 Luigi Acerbi

The long duration of the COVID-19 pandemic allowed for multiple bursts in the infection and death rates, the so-called epidemic waves. This complex behavior is no longer tractable by simple compartmental model and requires more…