相关论文: Multi-Modal CLIP-Informed Protein Editing

The conditional generation of proteins with desired functions is a key goal for generative models. Existing methods based on prompting of protein language models (PLMs) can generate proteins conditioned on a target functionality, such as a…

As extended reality (XR) is redefining how users interact with computing devices, research in human action recognition is gaining prominence. Typically, models deployed on immersive computing devices are static and limited to their default…

Contrastive Language-Image Pretraining (CLIP) stands out as a prominent method for image representation learning. Various architectures, from vision transformers (ViTs) to convolutional networks (ResNets) have been trained with CLIP to…

The rapid advancement of large language models (LLMs) and multimodal learning has transformed digital content creation and manipulation. Traditional visual editing tools require significant expertise, limiting accessibility. Recent strides…

Enzyme is the major workhorse to carry out the diverse cellular functions. It catalyzes the biological reactions with a high specificity, with its topology playing a crucial role. For ecologically safe production of numerous bioproducts…

Large-scale image-text contrastive pre-training models, such as CLIP, have been demonstrated to effectively learn high-quality multimodal representations. However, there is limited research on learning video-text representations for general…

Diffusion-based point editing methods have gained significant traction in image editing tasks due to their ability to manipulate image semantics and fine details by applying localized perturbations on the manifold of noise latent. However,…

How and where proteins interface with one another can ultimately impact the proteins' functions along with a range of other biological processes. As such, precise computational methods for protein interface prediction (PIP) come highly…

Generative modeling for protein engineering is key to solving fundamental problems in synthetic biology, medicine, and material science. We pose protein engineering as an unsupervised sequence generation problem in order to leverage the…

In recent years, protein-text models have gained significant attention for their potential in protein generation and understanding. Current approaches focus on integrating protein-related knowledge into large language models through…

Protein Language Models (PLMs) have emerged as performant and scalable tools for predicting the functional impact and clinical significance of protein-coding variants, but they still lag experimental accuracy. Here, we present a novel…

Molecular Dynamics (MD) simulations are fundamental computational tools for the study of proteins and their free energy landscapes. However, sampling protein conformational changes through MD simulations is challenging due to the relatively…

Recent advances in Protein Language Models (PLMs) have transformed protein engineering, yet unlike their counterparts in Natural Language Processing (NLP), current PLMs exhibit a fundamental limitation: they excel in either Protein Language…

The Contrastive Language-Image Pre-training (CLIP) framework has become a widely used approach for multimodal representation learning, particularly in image-text retrieval and clustering. However, its efficacy is constrained by three key…

Recently, efficient fine-tuning of large-scale pre-trained models has attracted increasing research interests, where linear probing (LP) as a fundamental module is involved in exploiting the final representations for task-dependent…

Model reduction, which aims to learn a simpler model of the original mixed integer linear programming (MILP), can solve large-scale MILP problems much faster. Most existing model reduction methods are based on variable reduction, which…

Image enhancement is a significant research area in the fields of computer vision and image processing. In recent years, many learning-based methods for image enhancement have been developed, where the Look-up-table (LUT) has proven to be…

Protein-protein bindings play a key role in a variety of fundamental biological processes, and thus predicting the effects of amino acid mutations on protein-protein binding is crucial. To tackle the scarcity of annotated mutation data,…

Large-scale vision-language pre-trained (VLP) models (e.g., CLIP) are renowned for their versatility, as they can be applied to diverse applications in a zero-shot setup. However, when these models are used in specific domains, their…

Accurate human posture classification in images and videos is crucial for automated applications across various fields, including work safety, physical rehabilitation, sports training, or daily assisted living. Recently, multimodal learning…