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Current cervical cytopathology whole slide image (WSI) screening primarily relies on detection-based approaches, which are limited in performance due to the expense and time-consuming annotation process. Multiple Instance Learning (MIL), a…

计算机视觉与模式识别 · 计算机科学 2024-07-17 Jialong Huang , Gaojie Li , Shichao Kan , Jianfeng Liu , Yixiong Liang

Whole slide pathology image classification presents challenges due to gigapixel image sizes and limited annotation labels, hindering model generalization. This paper introduces a prompt learning method to adapt large vision-language models…

Specific and effective breast cancer therapy relies on the accurate quantification of PD-L1 positivity in tumors, which appears in the form of brown stainings in high resolution whole slide images (WSIs). However, the retrieval and…

Multimodal approaches that integrate histology and genomics hold strong potential for precision oncology. However, phenotypic and genotypic heterogeneity limits the quality of intra-modal representations and hinders effective inter-modal…

计算机视觉与模式识别 · 计算机科学 2025-12-01 Yupei Zhang , Yating Huang , Wanming Hu , Lequan Yu , Hujun Yin , Chao Li

Tissue segmentation is a routine preprocessing step to reduce the computational cost of whole slide image (WSI) analysis by excluding background regions. Traditional image processing techniques are commonly used for tissue segmentation, but…

图像与视频处理 · 电气工程与系统科学 2024-01-25 Ruben T. Lucassen , Willeke A. M. Blokx , Mitko Veta

Predicting genetic mutations from whole slide images is indispensable for cancer diagnosis. However, existing work training multiple binary classification models faces two challenges: (a) Training multiple binary classifiers is inefficient…

计算机视觉与模式识别 · 计算机科学 2024-06-06 Gexin Huang , Chenfei Wu , Mingjie Li , Xiaojun Chang , Ling Chen , Ying Sun , Shen Zhao , Xiaodan Liang , Liang Lin

Identifying predictive covariates, which forecast individual treatment effectiveness, is crucial for decision-making across different disciplines such as personalized medicine. These covariates, referred to as biomarkers, are extracted from…

图像与视频处理 · 电气工程与系统科学 2024-12-10 Shuhan Xiao , Lukas Klein , Jens Petersen , Philipp Vollmuth , Paul F. Jaeger , Klaus H. Maier-Hein

Pathology images are considered the ``gold standard" for cancer diagnosis and treatment, with gigapixel images providing extensive tissue and cellular information. Existing methods fail to simultaneously extract global structural and local…

计算机视觉与模式识别 · 计算机科学 2025-02-17 Haoming Luo , Xiaotian Yu , Shengxuming Zhang , Jiabin Xia , Yang Jian , Yuning Sun , Liang Xue , Mingli Song , Jing Zhang , Xiuming Zhang , Zunlei Feng

Whole slide images (WSIs) are high-resolution, gigapixel sized images that pose significant computational challenges for traditional machine learning models due to their size and heterogeneity.In this paper, we present a scalable and…

计算机视觉与模式识别 · 计算机科学 2025-01-22 Ravi Kant Gupta , Shounak Das , Ardhendu Sekhar , Amit Sethi

Predicting microsatellite instability (MSI) status from routine hematoxylin and eosin (H&E) whole slide images (WSIs) offers a practical alternative to molecular testing, but models trained at one institution tend to generalize poorly to…

图像与视频处理 · 电气工程与系统科学 2026-05-05 Dasari Naga Raju

With the development of computer-aided diagnosis (CAD) and image scanning technology, Whole-slide Image (WSI) scanners are widely used in the field of pathological diagnosis. Therefore, WSI analysis has become the key to modern digital…

计算机视觉与模式识别 · 计算机科学 2021-02-23 Chen Li , Xintong Li , Md Rahaman , Xiaoyan Li , Hongzan Sun , Hong Zhang , Yong Zhang , Xiaoqi Li , Jian Wu , Yudong Yao , Marcin Grzegorzek

Objective: We develop a computer-aided diagnosis (CAD) system using deep learning approaches for lesion detection and classification on whole-slide images (WSIs) with breast cancer. The deep features being distinguishing in classification…

图像与视频处理 · 电气工程与系统科学 2021-08-29 Wei-Wen Hsu , Yongfang Wu , Chang Hao , Yu-Ling Hou , Xiang Gao , Yun Shao , Xueli Zhang , Tao He , Yanhong Tai

Deep learning is a powerful tool for whole slide image (WSI) analysis. Typically, when performing supervised deep learning, a WSI is divided into small patches, trained and the outcomes are aggregated to estimate disease grade. However,…

计算机视觉与模式识别 · 计算机科学 2022-05-20 Yi Zheng , Rushin H. Gindra , Emily J. Green , Eric J. Burks , Margrit Betke , Jennifer E. Beane , Vijaya B. Kolachalama

Prompt learning has emerged as a promising paradigm for adapting pre-trained vision-language models (VLMs) to few-shot whole slide image (WSI) classification by aligning visual features with textual representations, thereby reducing…

计算机视觉与模式识别 · 计算机科学 2025-10-01 Junjie Zhou , Wei Shao , Yagao Yue , Wei Mu , Peng Wan , Qi Zhu , Daoqiang Zhang

Histomorphology is crucial in cancer diagnosis. However, existing whole slide image (WSI) classification methods struggle to effectively incorporate histomorphology information, limiting their ability to capture key pathological features.…

计算机视觉与模式识别 · 计算机科学 2025-12-01 Baizhi Wang , Rui Yan , Wenxin Ma , Xu Zhang , Yuhao Wang , Xiaolong Li , Yunjie Gu , Zihang Jiang , S. Kevin Zhou

Whole Slide Imaging (WSI), which involves high-resolution digital scans of pathology slides, has become the gold standard for cancer diagnosis, but its gigapixel resolution and the scarcity of annotated datasets present challenges for deep…

图像与视频处理 · 电气工程与系统科学 2025-02-03 Rita Pereira , M. Rita Verdelho , Catarina Barata , Carlos Santiago

Molecular assays are standard of care for detecting genomic alterations in cancer prognosis and therapy selection but are costly, tissue-destructive and time-consuming. Artificial intelligence (AI) applied to routine hematoxylin and eosin…

Clinical adoption of multi-shot diffusion-weighted magnetic resonance imaging (multi-shot DWI) for body-wide tumor diagnostics is limited by severe motion-induced phase artifacts from respiration, peristalsis, and so on, compounded by…

Whole-slide images (WSIs) are fundamental for computational pathology, where accurate lesion segmentation is critical for clinical decision making. Existing methods partition WSIs into discrete patches, disrupting spatial continuity and…

计算机视觉与模式识别 · 计算机科学 2026-03-05 Yunheng Wu , Wenqi Huang , Liangyi Wang , Masahiro Oda , Yuichiro Hayashi , Daniel Rueckert , Kensaku Mori

Whole-slide images (WSIs) from cancer patients contain rich information that can be used for medical diagnosis or to follow treatment progress. To automate their analysis, numerous deep learning methods based on convolutional neural…

计算机视觉与模式识别 · 计算机科学 2026-02-18 Lucas Sancéré , Noémie Moreau , Katarzyna Bozek