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One of the promising methods for the treatment of complex diseases such as cancer is combinational therapy. Due to the combinatorial complexity, machine learning models can be useful in this field, where significant improvements have…

机器学习 · 计算机科学 2020-01-08 Işıksu Ekşioğlu , Mehmet Tan

Multi-view representation learning has developed rapidly over the past decades and has been applied in many fields. However, most previous works assumed that each view is complete and aligned. This leads to an inevitable deterioration in…

计算机视觉与模式识别 · 计算机科学 2022-11-10 Yiming Wang , Dongxia Chang , Zhiqiang Fu , Jie Wen , Yao Zhao

The paper utilizes the graph embeddings generated for entities of a large biomedical database to perform link prediction to capture various new relationships among different entities. A novel node similarity measure is proposed that…

信息检索 · 计算机科学 2021-11-01 Prakhar Gurawa , Matthias Nickles

In this paper, we propose Multi-View Dreaming, a novel reinforcement learning agent for integrated recognition and control from multi-view observations by extending Dreaming. Most current reinforcement learning method assumes a single-view…

人工智能 · 计算机科学 2022-03-22 Akira Kinose , Masashi Okada , Ryo Okumura , Tadahiro Taniguchi

Drugs are frequently prescribed to patients with the aim of improving each patient's medical state, but an unfortunate consequence of most prescription drugs is the occurrence of undesirable side effects. Side effects that occur in more…

机器学习 · 计算机科学 2016-11-15 Jenna Reps , Jonathan M. Garibaldi , Uwe Aickelin , Daniele Soria , Jack E. Gibson , Richard B. Hubbard

We propose a novel and efficient method for link prediction in bipartite networks, using \textit{formal concept analysis} (FCA) and the Transformer encoder. Link prediction in bipartite networks finds practical applications in various…

机器学习 · 计算机科学 2025-03-21 Hongyuan Yang , Siqi Peng , Akihiro Yamamoto

This work develops a multivariate extension of the Fixed Rank Kriging (FRK) framework for spatial prediction in settings where multiple spatial processes may provide complementary information. The goal is to preserve the computational…

统计方法学 · 统计学 2026-03-24 Gaia Caringi , Piercesare Secchi

Multi-frame detection algorithms can effectively utilize the correlation between consecutive echoes to improve the detection performance of weak targets. Existing efficient multi-frame detection algorithms are typically based on three…

信号处理 · 电气工程与系统科学 2025-12-16 Zhihao Lin , Chang Gao , Junkun Yan , Qingfu Zhang , Bo Chen , Hongwei Liu

Predicting accurate protein-ligand binding affinity is important in drug discovery but remains a challenge even with computationally expensive biophysics-based energy scoring methods and state-of-the-art deep learning approaches. Despite…

Drug-target interaction (DTI) prediction, which aims at predicting whether a drug will be bounded to a target, have received wide attention recently, with the goal to automate and accelerate the costly process of drug design. Most of the…

生物大分子 · 定量生物学 2023-06-27 Shengming Zhang , Yizhou Sun

In this paper, we consider the problem of disease diagnosis. Unlike the conventional learning paradigm that treats labels independently, we propose a knowledge-enhanced framework, that enables training visual representation with the…

计算机视觉与模式识别 · 计算机科学 2023-02-28 Chaoyi Wu , Xiaoman Zhang , Yanfeng Wang , Ya Zhang , Weidi Xie

This paper presents a new method for estimating high dimensional covariance matrices. The method, permuted rank-penalized least-squares (PRLS), is based on a Kronecker product series expansion of the true covariance matrix. Assuming an…

统计方法学 · 统计学 2013-12-25 Theodoros Tsiligkaridis , Alfred O. Hero

Relation extraction between drugs plays a crucial role in identifying drug drug interactions and predicting side effects. The advancement of machine learning methods in relation extraction, along with the development of large medical text…

计算与语言 · 计算机科学 2025-10-28 Ali Fata , Hossein Rahmani , Parinaz Soltanzadeh , Amirhossein Derakhshan , Behrouz Minaei Bidgoli

Background and Objectives: Multidrug Resistance (MDR) is a critical global health issue, causing increased hospital stays, healthcare costs, and mortality. This study proposes an interpretable Machine Learning (ML) framework for MDR…

We consider prediction in multiple studies with potential differences in the relationships between predictors and outcomes. Our objective is to integrate data from multiple studies to develop prediction models for unseen studies. We propose…

统计方法学 · 统计学 2024-07-23 Boyu Ren , Prasad Patil , Francesca Dominici , Giovanni Parmigiani , Lorenzo Trippa

In many modern applications, a carefully designed primary study provides individual-level data for interpretable modeling, while summary-level external information is available through black-box, efficient, and nonparametric…

统计方法学 · 统计学 2026-04-07 Chi-Shian Dai , Jun Shao

Statistical machine learning algorithms have achieved state-of-the-art results on benchmark datasets, outperforming humans in many tasks. However, the out-of-distribution data and confounder, which have an unpredictable causal relationship,…

计算机视觉与模式识别 · 计算机科学 2022-10-31 Changjie Lu

Representation learning offers a conduit to elucidate distinctive features within the latent space and interpret the deep models. However, the randomness of lesion distribution and the complexity of low-quality factors in medical images…

计算机视觉与模式识别 · 计算机科学 2024-04-09 Qingshan Hou , Shuai Cheng , Peng Cao , Jinzhu Yang , Xiaoli Liu , Osmar R. Zaiane , Yih Chung Tham

Predicting and discovering drug-drug interactions (DDIs) using machine learning has been studied extensively. However, most of the approaches have focused on text data or textual representation of the drug structures. We present the first…

机器学习 · 计算机科学 2021-03-22 Devendra Singh Dhami , Siwen Yan , Gautam Kunapuli , David Page , Sriraam Natarajan

Federated learning enables multiple hospitals to cooperatively learn a shared model without privacy disclosure. Existing methods often take a common assumption that the data from different hospitals have the same modalities. However, such a…

图像与视频处理 · 电气工程与系统科学 2023-06-06 Yunlu Yan , Hong Wang , Yawen Huang , Nanjun He , Lei Zhu , Yuexiang Li , Yong Xu , Yefeng Zheng