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When exposure measurement error (EME), confounder measurement error (CME), or both are present, health effect estimates regarding exposure mixtures and critical exposure time-window may not represent the true effects. For example, in air…

统计理论 · 数学 2025-05-28 Honghyok Kim

We consider a longitudinal data structure consisting of baseline covariates, time-varying treatment variables, intermediate time-dependent covariates, and a possibly time dependent outcome. Previous studies have shown that estimating the…

统计理论 · 数学 2018-10-09 Linh Tran , Maya Petersen , Joshua Schwab , Mark J van der Laan

Observational studies often use linear regression to assess the effect of ambient air pollution on outcomes of interest, such as human health indicators or crop yields. Yet pollution datasets are typically noisy and include only a subset of…

应用统计 · 统计学 2024-03-08 Dan M. Kluger , David B. Lobell , Art B. Owen

Measurement error in the covariate of main interest (e.g. the exposure variable, or the risk factor) is common in epidemiologic and health studies. It can effect the relative risk estimator or other types of coefficients derived from the…

统计方法学 · 统计学 2022-07-20 Sarit Agami

When examining a contrast between two interventions, longitudinal causal inference studies frequently encounter positivity violations when one or both regimes are impossible to observe for some subjects. Existing weighting methods either…

统计方法学 · 统计学 2025-08-11 Alec McClean , Iván Díaz

Introduction: Methods now exist to detect residual confounding. One requires an "indicator" with two key properties: conditional independence of the outcome (given exposure and measured covariates) absent confounding and other model…

统计方法学 · 统计学 2015-10-26 W. Dana Flanders , Matthew J. Strickland , Mitchel Klein

When estimating causal effects from observational studies, researchers often need to adjust for many covariates to deconfound the non-causal relationship between exposure and outcome, among which many covariates are discrete. The behavior…

统计理论 · 数学 2024-05-07 Zhenghao Zeng , Sivaraman Balakrishnan , Yanjun Han , Edward H. Kennedy

We propose a new approach for estimating causal effects when the exposure is measured with error and confounding adjustment is performed via a generalized propensity score (GPS). Using validation data, we propose a regression calibration…

Studying causal effects of continuous treatments is important for gaining a deeper understanding of many interventions, policies, or medications, yet researchers are often left with observational studies for doing so. In the observational…

统计方法学 · 统计学 2023-06-16 Jared D. Huling , Noah Greifer , Guanhua Chen

We show that causal effects can be identified when there is bunching in the distribution of a continuous treatment variable, without imposing any parametric assumptions. This yields a new nonparametric method for overcoming selection bias…

计量经济学 · 经济学 2025-07-08 Carolina Caetano , Gregorio Caetano , Leonard Goff , Eric Nielsen

Drawing causal inference with observational studies is the central pillar of many disciplines. One sufficient condition for identifying the causal effect is that the treatment-outcome relationship is unconfounded conditional on the observed…

统计理论 · 数学 2017-01-17 Peng Ding , Tyler VanderWeele , James Robins

Researchers often use instrumental variables (IV) models to investigate the causal relationship between an endogenous variable and an outcome while controlling for covariates. When an exogenous variable is unavailable to serve as the…

计量经济学 · 经济学 2025-06-18 Moses Stewart

A common concern when trying to draw causal inferences from observational data is that the measured covariates are insufficiently rich to account for all sources of confounding. In practice, many of the covariates may only be proxies of the…

统计方法学 · 统计学 2023-08-31 Oliver Dukes , Ilya Shpitser , Eric J. Tchetgen Tchetgen

Routinely collected data from electronic health records (EHR) provide opportunities to study effects of longitudinal treatment strategies in real-world clinical settings. A challenge presented by EHR data is that frequency of covariate…

应用统计 · 统计学 2026-04-14 Leah Pirondini , Karla Diaz-Ordaz , Edward Palmer , Ruth H. Keogh

Positivity violations, which occur when some subgroups either always or never receive a treatment of interest, pose significant challenges for causal effect estimation with observational data. Recent balancing weight methods have proved to…

统计方法学 · 统计学 2025-12-17 Martha Barnard , Jared D. Huling , Julian Wolfson

The increasing multiplicity of data sources offers exciting possibilities in estimating the effects of a treatment, intervention, or exposure, particularly if observational and experimental sources could be used simultaneously. Borrowing…

统计方法学 · 统计学 2020-03-24 Jeffrey A. Boatman , David M. Vock , Joseph S. Koopmeiners

Consider sensitivity analysis for estimating average treatment effects under unmeasured confounding, assumed to satisfy a marginal sensitivity model. At the population level, we provide new representations for the sharp population bounds…

统计方法学 · 统计学 2022-09-26 Zhiqiang Tan

We present a method for assessing the sensitivity of the true causal effect to unmeasured confounding. The method requires the analyst to set two intuitive parameters. Otherwise, the method is assumption-free. The method returns an interval…

统计方法学 · 统计学 2022-02-07 Jose M. Peña

Modern medical research demands specialized causal inference methods evaluating complex continuous-time dynamic treatment regimens using observational data. For instance, obtaining the causal effects of intravenous administration, a…

统计方法学 · 统计学 2026-04-02 Haiyan Zhu , Yingchun Zhou

In many scientific studies, it is of interest to determine whether an exposure has a causal effect on an outcome. In observational studies, this is a challenging task due to the presence of confounding variables that affect both the…

统计方法学 · 统计学 2020-10-07 Ted Westling