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People with type 1 diabetes (T1D) lack the ability to produce the insulin their bodies need. As a result, they must continually make decisions about how much insulin to self-administer to adequately control their blood glucose levels.…

机器学习 · 计算机科学 2020-09-22 Ian Fox , Joyce Lee , Rodica Pop-Busui , Jenna Wiens

Type 1 Diabetes (T1D) management requires continuous adjustment of insulin and lifestyle behaviors to maintain blood glucose within a safe target range. Although automated insulin delivery (AID) systems have improved glycemic outcomes, many…

Blood Glucose (BG) control involves keeping an individual's BG within a healthy range through extracorporeal insulin injections is an important task for people with type 1 diabetes. However,traditional patient self-management is cumbersome…

人工智能 · 计算机科学 2024-03-18 Weiwei Gu , Senquan Wang

Managing physiological variables within clinically safe target zones is a central challenge in healthcare, particularly for chronic conditions such as Type 1 Diabetes Mellitus (T1DM). Reinforcement learning (RL) offers promise for…

机器学习 · 计算机科学 2025-08-07 David H. Mguni , Jing Dong , Wanrong Yang , Ziquan Liu , Muhammad Salman Haleem , Baoxiang Wang

Type 1 Diabetes (T1D) management is a complex task due to many variability factors. Artificial Pancreas (AP) systems have alleviated patient burden by automating insulin delivery through advanced control algorithms. However, the…

机器学习 · 计算机科学 2025-11-03 Stefano De Carli , Nicola Licini , Davide Previtali , Fabio Previdi , Antonio Ferramosca

In this paper we investigate the use of model-based reinforcement learning to assist people with Type 1 Diabetes with insulin dose decisions. The proposed architecture consists of multiple Echo State Networks to predict blood glucose levels…

The widespread adoption of effective hybrid closed loop systems would represent an important milestone of care for people living with type 1 diabetes (T1D). These devices typically utilise simple control algorithms to select the optimal…

机器学习 · 计算机科学 2023-05-08 Harry Emerson , Matthew Guy , Ryan McConville

Automated insulin delivery for Type 1 Diabetes must balance glucose control and safety under uncertain meals and physiological variability. While reinforcement learning (RL) enables adaptive personalization, existing approaches struggle to…

机器学习 · 计算机科学 2026-01-23 Yushen Liu , Yanfu Zhang , Xugui Zhou

Reinforcement learning (RL) has demonstrated success in automating insulin dosing in simulated type 1 diabetes (T1D) patients but is currently unable to incorporate patient expertise and preference. This work introduces PAINT (Preference…

人工智能 · 计算机科学 2025-01-28 Harry Emerson , Sam Gordon James , Matthew Guy , Ryan McConville

We propose a dual-hormone delivery strategy by exploiting deep reinforcement learning (RL) for people with Type 1 Diabetes (T1D). Specifically, double dilated recurrent neural networks (RNN) are used to learn the hormone delivery strategy,…

定量方法 · 定量生物学 2019-10-10 Taiyu Zhu , Kezhi Li , Pantelis Georgiou

This paper presents a novel multi-agent reinforcement learning (RL) approach for personalized glucose control in individuals with type 1 diabetes (T1D). The method employs a closed-loop system consisting of a blood glucose (BG) metabolic…

机器学习 · 计算机科学 2023-07-24 Mehrad Jaloli , Marzia Cescon

Accurate prediction of future blood glucose (BG) levels can effectively improve BG management for people living with diabetes, thereby reducing complications and improving quality of life. The state of the art of BG prediction has been…

机器学习 · 计算机科学 2024-02-27 Chengzhe Piao , Taiyu Zhu , Stephanie E Baldeweg , Paul Taylor , Pantelis Georgiou , Jiahao Sun , Jun Wang , Kezhi Li

People with Type 1 diabetes (T1D) require regular exogenous infusion of insulin to maintain their blood glucose concentration in a therapeutically adequate target range. Although the artificial pancreas and continuous glucose monitoring…

信号处理 · 电气工程与系统科学 2020-09-08 Taiyu Zhu , Kezhi Li , Pau Herrero , Pantelis Georgiou

Type 1 Diabetes is a chronic autoimmune condition in which the immune system attacks and destroys insulin-producing beta cells in the pancreas, resulting in little to no insulin production. Insulin helps glucose in your blood enter your…

定量方法 · 定量生物学 2025-02-04 Soon Jynn Chu , Nalaka Amarasiri , Sandesh Giri , Priyata Kafle

Control of blood glucose is essential for diabetes management. Current digital therapeutic approaches for subjects with Type 1 diabetes mellitus (T1DM) such as the artificial pancreas and insulin bolus calculators leverage machine learning…

计算机视觉与模式识别 · 计算机科学 2019-02-27 Kezhi Li , John Daniels , Chengyuan Liu , Pau Herrero , Pantelis Georgiou

In this paper, a novel robust tracking control scheme for a general class of discrete-time nonlinear systems affected by unknown bounded uncertainty is presented. By solving a parameterized optimal tracking control problem subject to the…

系统与控制 · 电气工程与系统科学 2023-12-08 Alexandros Tanzanakis , John Lygeros

Self-monitoring of blood glucose (SMBG) and continuous glucose monitoring (CGM) are commonly used by type 1 diabetes (T1D) patients to measure glucose concentrations. The proposed adaptive basal-bolus algorithm (ABBA) supports inputs from…

系统与控制 · 电气工程与系统科学 2024-12-20 Qingnan Sun , Marko V. Jankovic , João Budzinski , Brett Moore , Peter Diem , Christoph Stettler , Stavroula G. Mougiakakou

People with type 1 diabetes (T1D) struggle to calculate the optimal insulin dose at mealtime, especially when under multiple daily injections (MDI) therapy. Effectively, they will not always perform rigorous and precise calculations, but…

人工智能 · 计算机科学 2023-09-19 Anas El Fathi , Marc D. Breton

This paper proposes a robust control design method using reinforcement-learning for controlling partially-unknown dynamical systems under uncertain conditions. The method extends the optimal reinforcement-learning algorithm with a new…

系统与控制 · 电气工程与系统科学 2020-04-17 Phuong D. Ngo , Fred Godtliebsen

Patients with Type I Diabetes (T1D) must take insulin injections to prevent the serious long term effects of hyperglycemia - high blood glucose (BG). Patients must also be careful not to inject too much insulin because this could induce…

机器学习 · 计算机科学 2019-04-01 Neil C. Borle , Edmond A. Ryan , Russell Greiner
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