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Whole-slide image classification represents a key challenge in computational pathology and medicine. Attention-based multiple instance learning (MIL) has emerged as an effective approach for this problem. However, the effect of attention…

Foundation models (FMs) have transformed computational pathology by providing powerful, general-purpose feature extractors. However, adapting and benchmarking individual FMs for specific diagnostic tasks is often time-consuming and…

计算机视觉与模式识别 · 计算机科学 2025-10-07 Peiran Quan , Zifan Gu , Zhuo Zhao , Qin Zhou , Donghan M. Yang , Ruichen Rong , Yang Xie , Guanghua Xiao

Digitizing pathological images into gigapixel Whole Slide Images (WSIs) has opened new avenues for Computational Pathology (CPath). As positive tissue comprises only a small fraction of gigapixel WSIs, existing Multiple Instance Learning…

计算机视觉与模式识别 · 计算机科学 2025-09-16 Wenhao Tang , Sheng Huang , Heng Fang , Fengtao Zhou , Bo Liu , Qingshan Liu

Multiple instance learning (MIL) has been increasingly used in the classification of histopathology whole slide images (WSIs). However, MIL approaches for this specific classification problem still face unique challenges, particularly those…

计算机视觉与模式识别 · 计算机科学 2022-03-24 Hongrun Zhang , Yanda Meng , Yitian Zhao , Yihong Qiao , Xiaoyun Yang , Sarah E. Coupland , Yalin Zheng

Recent advances in attention-based multiple instance learning (MIL) have improved our insights into the tissue regions that models rely on to make predictions in digital pathology. However, the interpretability of these approaches is still…

Multi-instance learning (MIL) is a widely-applied technique in practical applications that involve complex data structures. MIL can be broadly categorized into two types: traditional methods and those based on deep learning. These…

人工智能 · 计算机科学 2023-04-25 Yu-Xuan Zhang , Zhengchun Zhou , Xingxing He , Avik Ranjan Adhikary , Bapi Dutta

Multiple instance learning (MIL) has emerged as the dominant paradigm for whole slide image (WSI) analysis in computational pathology, achieving strong diagnostic performance through patch-level feature aggregation. However, existing MIL…

计算机视觉与模式识别 · 计算机科学 2025-11-17 Yiran Song , Yikai Zhang , Shuang Zhou , Guojun Xiong , Xiaofeng Yang , Nian Wang , Fenglong Ma , Rui Zhang , Mingquan Lin

Multiple Instance Learning is the predominant method for Whole Slide Image classification in digital pathology, enabling the use of slide-level labels to supervise model training. Although MIL eliminates the tedious fine-grained annotation…

计算机视觉与模式识别 · 计算机科学 2025-05-28 Chen Shu , Boyu Fu , Yiman Li , Ting Yin , Wenchuan Zhang , Jie Chen , Yuhao Yi , Hong Bu

Deep learning has shown remarkable progress in medical image semantic segmentation, yet its success heavily depends on large-scale expert annotations and consistent data distributions. In practice, annotations are scarce, and images are…

计算机视觉与模式识别 · 计算机科学 2026-01-26 Ba-Thinh Lam , Thanh-Huy Nguyen , Hoang-Thien Nguyen , Quang-Khai Bui-Tran , Nguyen Lan Vi Vu , Phat K. Huynh , Ulas Bagci , Min Xu

Pathology detection and delineation enables the automatic interpretation of medical scans such as chest X-rays while providing a high level of explainability to support radiologists in making informed decisions. However, annotating…

计算机视觉与模式识别 · 计算机科学 2023-09-07 Philip Müller , Felix Meissen , Johannes Brandt , Georgios Kaissis , Daniel Rueckert

Whole-slide image (WSI) classification in computational pathology is commonly formulated as slide-level Multiple Instance Learning (MIL) with a single global bag representation. However, slide-level MIL is fundamentally underconstrained:…

Background: Image classification can be considered one of the key pillars of medical image analysis. Deep learning (DL) faces challenges that prevent its practical applications despite the remarkable improvement in medical image…

图像与视频处理 · 电气工程与系统科学 2026-02-19 Shahabedin Nabavi , Kian Anvari Hamedani , Mohsen Ebrahimi Moghaddam , Ahmad Ali Abin , Alejandro F. Frangi

In many real-world machine learning applications, samples belong to a set of domains e.g., for product reviews each review belongs to a product category. In this paper, we study multi-domain imbalanced learning (MIL), the scenario that…

机器学习 · 计算机科学 2022-04-06 Zixuan Ke , Mohammad Kachuee , Sungjin Lee

Numerous studies have explored image-based automated systems for plant disease diagnosis, demonstrating impressive diagnostic capabilities. However, recent large-scale analyses have revealed a critical limitation: that the diagnostic…

计算机视觉与模式识别 · 计算机科学 2024-12-30 Shoma Kudo , Satoshi Kagiwada , Hitoshi Iyatomi

In recent years, the integration of pre-trained foundational models with multiple instance learning (MIL) has improved diagnostic accuracy in computational pathology. However, existing MIL methods focus on optimizing feature extractors and…

计算机视觉与模式识别 · 计算机科学 2025-12-24 Le Feng , Li Xiao

The hypothesis that computational models can be reliable enough to be adopted in prognosis and patient care is revolutionizing healthcare. Deep learning, in particular, has been a game changer in building predictive models, thus leading to…

机器学习 · 统计学 2019-06-17 Jayaraman J. Thiagarajan , Deepta Rajan , Prasanna Sattigeri

Deploying digital pathology models across medical centers is challenging due to distribution shifts. Recent advances in domain generalization improve model transferability in terms of aggregated performance measured by the Area Under Curve…

计算机视觉与模式识别 · 计算机科学 2025-07-25 Arthur Pignet , John Klein , Genevieve Robin , Antoine Olivier

Whole Slide Image (WSI) classification relies on Multiple Instance Learning (MIL) with spatial patch features, yet existing methods struggle to capture global dependencies due to the immense size of WSIs and the local nature of patch…

计算机视觉与模式识别 · 计算机科学 2025-10-22 Anthony Bilic , Guangyu Sun , Ming Li , Md Sanzid Bin Hossain , Yu Tian , Wei Zhang , Laura Brattain , Dexter Hadley , Chen Chen

Pathology foundation models (PFMs) have emerged as powerful pretrained encoders for computational pathology, but their robustness under clinically relevant distribution shifts remains insufficiently understood. We benchmark the robustness…

图像与视频处理 · 电气工程与系统科学 2026-04-29 Fredrik K. Gustafsson , Mattias Rantalainen

Multiple instance learning (MIL) is the dominant framework for whole-slide image analysis in computational pathology, typically combining a frozen patch encoder, a projection layer, and a slide-level aggregator. While encoders and…

定量方法 · 定量生物学 2026-05-19 Yucheng Xing , Pei Liu , Jingying Ma , Ruping Hong , Jiangdong Qiu , Tianyu Liu , Kai He , Ling Huang , Mengling Feng