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Unsupervised clustering algorithms for vectors has been widely used in the area of machine learning. Many applications, including the biological data we studied in this paper, contain some boundary datapoints which show combination…

机器学习 · 计算机科学 2022-05-23 Yingcong Li , Chandra Sekhar Mukherjee , Jiapeng Zhang

High-dimensional single-cell data poses significant challenges in identifying underlying biological patterns due to the complexity and heterogeneity of cellular states. We propose a comprehensive gene-cell dependency visualization via…

机器学习 · 计算机科学 2024-07-25 Shang-Jung Wen , Jia-Ming Chang , Fang Yu

Sparse Subspace Clustering (SSC) has achieved state-of-the-art clustering quality by performing spectral clustering over a $\ell^{1}$-norm based similarity graph. However, SSC is a transductive method which does not handle with the data not…

机器学习 · 计算机科学 2014-09-11 Xi Peng , Lei Zhang , Zhang Yi

Graph Neural Networks (GNN) are reshaping our understanding of biomedicine and diseases by revealing the deep connections among genes and cells. As both algorithmic and biomedical technologies have advanced significantly, we're entering a…

Multi-view subspace clustering (MSC) is a popular unsupervised method by integrating heterogeneous information to reveal the intrinsic clustering structure hidden across views. Usually, MSC methods use graphs (or affinity matrices) fusion…

机器学习 · 计算机科学 2023-08-15 Yidi Wang , Xiaobing Pei , Haoxi Zhan

Most existing popular methods for learning graph embedding only consider fixed-order global structural features and lack structures hierarchical representation. To address this weakness, we propose a novel graph embedding algorithm named…

机器学习 · 计算机科学 2021-02-03 Xue Liu , Wei Wei , Xiangnan Feng , Xiaobo Cao , Dan Sun

Graph condensation, which reduces the size of a large-scale graph by synthesizing a small-scale condensed graph as its substitution, has immediate benefits for various graph learning tasks. However, existing graph condensation methods rely…

机器学习 · 计算机科学 2023-10-24 Xin Zheng , Miao Zhang , Chunyang Chen , Quoc Viet Hung Nguyen , Xingquan Zhu , Shirui Pan

Modeling cellular dynamics from single-cell RNA sequencing (scRNA-seq) data is critical for understanding cell development and underlying gene regulatory relationships. Many current methods rely on single-cell velocity to obtain pseudotime,…

分子网络 · 定量生物学 2024-10-25 Zhen Zhou , Jiachen Li , Hongyi Xin , Xiaoyong Pan , Hong-Bin Shen

Partitioning a graph into groups of vertices such that those within each group are more densely connected than vertices assigned to different groups, known as graph clustering, is often used to gain insight into the organisation of large…

机器学习 · 统计学 2014-01-28 Charanpal Dhanjal , Romaric Gaudel , Stéphan Clémençon

As the key advancement of the convolutional neural networks (CNNs), depthwise separable convolutions (DSCs) are becoming one of the most popular techniques to reduce the computations and parameters size of CNNs meanwhile maintaining the…

机器学习 · 计算机科学 2021-01-05 Yuke Wang , Boyuan Feng , Yufei Ding

Multi-organ segmentation is a critical task in computer-aided diagnosis. While recent deep learning methods have achieved remarkable success in image segmentation, huge variations in organ size and shape challenge their effectiveness in…

图像与视频处理 · 电气工程与系统科学 2025-10-31 Xizhi Tian , Changjun Zhou , Yulin. Yang

Inferring gene regulatory networks (GRNs) from single-cell RNA sequencing (scRNA-seq) data is a complex challenge that requires capturing the intricate relationships between genes and their regulatory interactions. In this study, we tackle…

机器学习 · 计算机科学 2024-07-26 Sindhura Kommu , Yizhi Wang , Yue Wang , Xuan Wang

Semi-supervised learning (SSL) has made notable advancements in medical image segmentation (MIS), particularly in scenarios with limited labeled data and significantly enhancing data utilization efficiency. Previous methods primarily focus…

计算机视觉与模式识别 · 计算机科学 2024-11-25 Mengzhu Wang , Jiao Li , Houcheng Su , Nan Yin , Liang Yang , Shen Li

Determining phenotypes of diseases can have considerable benefits for in-hospital patient care and to drug development. The structure of high dimensional data sets such as electronic health records are often represented through an embedding…

We study the problem of clustering nodes in a dynamic graph, where the connections between nodes and nodes' cluster memberships may change over time, e.g., due to community migration. We first propose a dynamic stochastic block model that…

机器学习 · 计算机科学 2021-06-24 Yuhang Yao , Carlee Joe-Wong

The problem of estimating the structure of a graph from observed data is of growing interest in the context of high-throughput genomic data, and single-cell RNA sequencing in particular. These, however, are challenging applications, since…

基因组学 · 定量生物学 2023-02-15 Thi Kim Hue Nguyen , Koen Van den Berge , Monica Chiogna , Davide Risso

Graph Representation Learning (GRL) is an influential methodology, enabling a more profound understanding of graph-structured data and aiding graph clustering, a critical task across various domains. The recent incursion of attention…

机器学习 · 计算机科学 2023-08-15 Shuo Han , Jiacheng Liu , Jiayun Wu , Yinan Chen , Li Tao

Generative modeling of single-cell RNA-seq data is crucial for tasks like trajectory inference, batch effect removal, and simulation of realistic cellular data. However, recent deep generative models simulating synthetic single cells from…

定量方法 · 定量生物学 2025-03-04 Alessandro Palma , Till Richter , Hanyi Zhang , Manuel Lubetzki , Alexander Tong , Andrea Dittadi , Fabian Theis

The emergence of graph neural networks (GNNs) has offered a powerful tool for semi-supervised node classification tasks. Subsequent studies have achieved further improvements through refining the message passing schemes in GNN models or…

机器学习 · 计算机科学 2025-11-26 Songbo Wang , Renchi Yang , Yurui Lai , Xiaoyang Lin , Tsz Nam Chan

The intrinsic dynamics and event-driven nature of spiking neural networks (SNNs) make them excel in processing temporal information by naturally utilizing embedded time sequences as time steps. Recent studies adopting this approach have…

机器学习 · 计算机科学 2024-12-18 Jiaqi Wang , Liutao Yu , Liwei Huang , Chenlin Zhou , Han Zhang , Zhenxi Song , Min Zhang , Zhengyu Ma , Zhiguo Zhang