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The area under the curve (AUC) of the mean cumulative function (MCF) has recently been introduced as a novel estimand for evaluating treatment effects in recurrent event settings, offering an alternative to the commonly used…

统计方法学 · 统计学 2025-07-22 Jiren Sun , Tuo Wang , Yanyao Yi , Ting Ye , Jun Shao , Yu Du

A treatment may be appropriate for some group (the ``sick" group) on whom it has a positive effect, but it can also have a detrimental effect on subjects from another group (the ``healthy" group). In a non-targeted trial both sick and…

机器学习 · 计算机科学 2025-04-23 Georgios Mavroudeas , Malik Magdon-Ismail , Kristin P. Bennett , Jason Kuruzovich

The use of artificial intelligence in clinical care to improve decision support systems is increasing. This is not surprising since, by its very nature, the practice of medicine consists of making decisions based on observations from…

定量方法 · 定量生物学 2019-05-03 Isaac Mativo , Yelena Yesha , Michael Grasso , Tim Oates , Qian Zhu

In this study, we investigated the application of bio-inspired optimization algorithms, including Genetic Algorithm, Particle Swarm Optimization, and Whale Optimization Algorithm, for feature selection in chronic disease prediction. The…

神经与进化计算 · 计算机科学 2024-01-12 Abeer Dyoub , Ivan Letteri

Data on hundreds of variables related to individual consumer finance behavior (such as credit card and loan activity) is routinely collected in many countries and plays an important role in lending decisions. We postulate that the detailed…

综合经济学 · 经济学 2021-11-09 Giacomo De Giorgi , Matthew Harding , Gabriel Vasconcelos

There are limited options to estimate the treatment effects of variables which are continuous and measured at multiple time points, particularly if the true dose-response curve should be estimated as closely as possible. However, these…

统计方法学 · 统计学 2024-10-11 Michael Schomaker , Helen McIlleron , Paolo Denti , Iván Díaz

We develop here a data-driven approach for disease recognition based on given symptoms, to be efficient tool for anomaly detection. In a clinical setting and when presented with a patient with a combination of traits, a doctor may wonder if…

种群与进化 · 定量生物学 2020-05-01 Abd AlRahman AlMomani , Erik Bollt

Identifying frail older adults in an ageing population is essential for improving healthcare services. This study proposes a composite indicator to assess individual frailty levels using administrative healthcare data. Given the complex and…

统计方法学 · 统计学 2025-10-07 Sara Rebottini , Pietro Belloni

Causal inference across multiple data sources offers a promising avenue to enhance the generalizability and replicability of scientific findings. However, data integration methods for time-to-event outcomes, common in biomedical research,…

统计方法学 · 统计学 2025-05-16 Yi Liu , Alexander W. Levis , Ke Zhu , Shu Yang , Peter B. Gilbert , Larry Han

The relative case fatality rates (CFRs) between groups and countries are key measures of relative risk that guide policy decisions regarding scarce medical resource allocation during the ongoing COVID-19 pandemic. In the middle of an active…

定量方法 · 定量生物学 2022-12-08 Anastasios Nikolas Angelopoulos , Reese Pathak , Rohit Varma , Michael I. Jordan

An individualized risk prediction model that dynamically updates the probability of a clinical event from a specific cause is valuable for physicians to be able to optimize personalized treatment strategies in real-time by incorporating all…

统计方法学 · 统计学 2019-04-22 Qing Liu , Gong Tang , Joseph P. Costantino , Chung-Chou H. Chang

This paper deals with the problem of estimating the finite population mean when some information on two auxiliary attributes are available. It is shown that the proposed estimator is more efficient than the usual mean estimator and other…

统计理论 · 数学 2013-02-08 Sachin Malik , Rajesh Singh

Survival analysis aims at modeling the relationship between covariates and event occurrence with some untracked (censored) samples. In implementation, existing methods model the survival distribution with strong assumptions or in a discrete…

机器学习 · 计算机科学 2023-05-25 Yu Ling , Weimin Tan , Bo Yan

In causality, estimating the effect of a treatment without confounding inference remains a major issue because requires to assess the outcome in both case with and without treatment. Not being able to observe simultaneously both of them,…

机器学习 · 计算机科学 2021-12-09 Celine Beji , Florian Yger , Jamal Atif

Two-phase sampling designs have been widely adopted in epidemiological studies to reduce costs when measuring certain biomarkers is prohibitively expensive. Under these designs, investigators commonly relate survival outcomes to risk…

统计方法学 · 统计学 2025-12-12 Jooho Kim , Yei Eun Shin

Electronic medical records (EMRs) supports the development of machine learning algorithms for predicting disease incidence, patient response to treatment, and other healthcare events. But insofar most algorithms have been centralized,…

机器学习 · 计算机科学 2019-03-25 Li Huang , Dianbo Liu

We consider methods for causal inference in randomized trials nested within cohorts of trial-eligible individuals, including those who are not randomized. We show how baseline covariate data from the entire cohort, and treatment and outcome…

统计方法学 · 统计学 2019-10-30 Issa Dahabreh , Sarah Robertson , Eric Tchetgen Tchetgen , Elizabeth Stuart , Miguel Hernan

Observational cohort studies with oversampled exposed subjects are typically implemented to understand the causal effect of a rare exposure. Because the distribution of exposed subjects in the sample differs from the source population,…

统计方法学 · 统计学 2019-02-14 Sherri Rose

Infectious disease modeling and forecasting have played a key role in helping assess and respond to epidemics and pandemics. Recent work has leveraged data on disease peak infection and peak hospital incidence to fit compartmental models…

Idiopathic Pulmonary Fibrosis (IPF) is an inexorably progressive fibrotic lung disease with a variable and unpredictable rate of progression. CT scans of the lungs inform clinical assessment of IPF patients and contain pertinent information…

图像与视频处理 · 电气工程与系统科学 2022-03-23 Ahmed H. Shahin , Joseph Jacob , Daniel C. Alexander , David Barber