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Estimating the causal effect of time-varying treatments on survival outcomes is a challenging task in many domains, particularly in medicine where treatment protocols adapt over time. While recent advances in representation learning have…

机器学习 · 统计学 2025-05-06 Ayoub Abraich

Presence of bias (in datasets or tasks) is inarguably one of the most critical challenges in machine learning applications that has alluded to pivotal debates in recent years. Such challenges range from spurious associations between…

计算机视觉与模式识别 · 计算机科学 2020-11-23 Ehsan Adeli , Qingyu Zhao , Adolf Pfefferbaum , Edith V. Sullivan , Li Fei-Fei , Juan Carlos Niebles , Kilian M. Pohl

Contrastive learning has recently emerged as a promising approach for learning data representations that discover and disentangle the explanatory factors of the data. Previous analyses of such approaches have largely focused on individual…

机器学习 · 计算机科学 2023-11-09 Stefan Matthes , Zhiwei Han , Hao Shen

Treatment effect estimation involves assessing the impact of different treatments on individual outcomes. Current methods estimate Conditional Average Treatment Effect (CATE) using observational datasets where covariates are collected…

机器学习 · 计算机科学 2025-02-10 Lokesh Nagalapatti , Pranava Singhal , Avishek Ghosh , Sunita Sarawagi

Contrastive learning has emerged as a powerful framework for learning generalizable representations, yet its theoretical understanding remains limited, particularly under imbalanced data distributions that are prevalent in real-world…

机器学习 · 计算机科学 2026-02-12 Haixu Liao , Yating Zhou , Songyang Zhang , Meng Wang , Shuai Zhang

Drug-target interaction (DTI) prediction is crucial for drug development and repositioning. Methods using heterogeneous graph neural networks (HGNNs) for DTI prediction have become a promising approach, with attention-based models often…

生物大分子 · 定量生物学 2024-11-05 Junwei Hu , Michael Bewong , Selasi Kwashie , Wen Zhang , Vincent M. Nofong , Guangsheng Wu , Zaiwen Feng

Efficiently and flexibly estimating treatment effect heterogeneity is an important task in a wide variety of settings ranging from medicine to marketing, and there are a considerable number of promising conditional average treatment effect…

机器学习 · 统计学 2023-05-10 Erik Sverdrup , Yifan Cui

Predicting drug response in patients from preclinical data remains a major challenge in precision oncology due to the substantial biological gap between in vitro cell lines and patient tumors. Rather than aiming to improve absolute in vitro…

机器学习 · 计算机科学 2026-03-18 Camille Jimenez Cortes , Philippe Lalanda , German Vega

Many applications of causal inference require using treatment effects estimated on a study population to make decisions in a separate target population. We consider the challenging setting where there are covariates that are observed in the…

机器学习 · 计算机科学 2024-10-22 Khurram Yamin , Vibhhu Sharma , Ed Kennedy , Bryan Wilder

Most machine learning (ML) models are developed for prediction only; offering no option for causal interpretation of their predictions or parameters/properties. This can hamper the health systems' ability to employ ML models in clinical…

Learning data representations under uncertainty is an important task that emerges in numerous scientific computing and data analysis applications. However, uncertainty quantification techniques are computationally intensive and become…

Many Click-Through Rate (CTR) prediction works focused on designing advanced architectures to model complex feature interactions but neglected the importance of feature representation learning, e.g., adopting a plain embedding layer for…

信息检索 · 计算机科学 2022-12-02 Fangye Wang , Yingxu Wang , Dongsheng Li , Hansu Gu , Tun Lu , Peng Zhang , Ning Gu

Heterogeneous treatment effect estimation in high-stakes applications demands models that simultaneously optimize precision, interpretability, and calibration. Many existing tree-based causal inference techniques, however, exhibit high…

机器学习 · 计算机科学 2025-04-21 Yichen Liu

Invariant Contrastive Learning (ICL) methods have achieved impressive performance across various domains. However, the absence of latent space representation for distortion (augmentation)-related information in the latent space makes ICL…

Estimating heterogeneous treatment effects (HTEs) over time is crucial in many disciplines such as personalized medicine. For example, electronic health records are commonly collected over several time periods and then used to personalize…

机器学习 · 计算机科学 2025-02-07 Dennis Frauen , Konstantin Hess , Stefan Feuerriegel

The foremost challenge to causal inference with real-world data is to handle the imbalance in the covariates with respect to different treatment options, caused by treatment selection bias. To address this issue, recent literature has…

机器学习 · 统计学 2022-02-23 Zhixuan Chu , Stephen Rathbun , Sheng Li

An important task in drug development is to identify patients, which respond better or worse to an experimental treatment. Identifying predictive covariates, which influence the treatment effect and can be used to define subgroups of…

统计方法学 · 统计学 2018-11-27 Marius Thomas , Björn Bornkamp , Katja Ickstadt

Contrastive dimension reduction methods have been developed for case-control study data to identify variation that is enriched in the foreground (case) data X relative to the background (control) data Y. Here, we develop contrastive…

统计方法学 · 统计学 2024-01-09 Boyang Zhang , Sarah Nyquist , Andrew Jones , Barbara E. Engelhardt , Didong Li

Individual Treatment Effects (ITE) estimation methods have risen in popularity in the last years. Most of the time, individual effects are better presented as Conditional Average Treatment Effects (CATE). Recently, representation balancing…

机器学习 · 统计学 2022-03-30 Ayoub Abraich , Agathe Guilloux , Blaise Hanczar

With the advent of big data across multiple high-impact applications, we are often facing the challenge of complex heterogeneity. The newly collected data usually consist of multiple modalities and are characterized with multiple labels,…

机器学习 · 计算机科学 2022-07-27 Lecheng Zheng , Jinjun Xiong , Yada Zhu , Jingrui He