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Stain normalization often refers to transferring the color distribution of the source image to that of the target image and has been widely used in biomedical image analysis. The conventional stain normalization is regarded as constructing…

图像与视频处理 · 电气工程与系统科学 2021-11-09 Hongtao Kang , Die Luo , Weihua Feng , Junbo Hu , Shaoqun Zeng , Tingwei Quan , Xiuli Liu

Deep learning models that are trained on histopathological images obtained from a single lab and/or scanner give poor inference performance on images obtained from another scanner/lab with a different staining protocol. In recent years,…

图像与视频处理 · 电气工程与系统科学 2020-10-07 Harshal Nishar , Nikhil Chavanke , Nitin Singhal

While human observers are able to cope with variations in color and appearance of histological stains, digital pathology algorithms commonly require a well-normalized setting to achieve peak performance, especially when a limited amount of…

计算机视觉与模式识别 · 计算机科学 2017-08-15 Daniel Bug , Steffen Schneider , Anne Grote , Eva Oswald , Friedrich Feuerhake , Julia Schüler , Dorit Merhof

Staining reveals the micro structure of the aspirate while creating histopathology slides. Stain variation, defined as a chromatic difference between the source and the target, is caused by varying characteristics during staining, resulting…

图像与视频处理 · 电气工程与系统科学 2022-08-31 Nilanjan Chattopadhyay , Shiv Gehlot , Nitin Singhal

Hematoxylin and Eosin (H&E) staining is widely regarded as the standard in pathology for diagnosing diseases and tracking tumor recurrence. While H&E staining shows tissue structures, it lacks the ability to reveal specific proteins that…

图像与视频处理 · 电气工程与系统科学 2025-05-21 Tushar Kataria , Beatrice Knudsen , Shireen Y. Elhabian

Neural Style Transfer (NST) is the field of study applying neural techniques to modify the artistic appearance of a content image to match the style of a reference style image. Traditionally, NST methods have focused on texture-based image…

计算机视觉与模式识别 · 计算机科学 2023-07-12 Dan Ruta , Gemma Canet Tarrés , Andrew Gilbert , Eli Shechtman , Nicholas Kolkin , John Collomosse

The diagnosis of cancer is mainly performed by visual analysis of the pathologists, through examining the morphology of the tissue slices and the spatial arrangement of the cells. If the microscopic image of a specimen is not stained, it…

图像与视频处理 · 电气工程与系统科学 2020-02-06 Pegah Salehi , Abdolah Chalechale

Despite the impressive results of arbitrary image-guided style transfer methods, text-driven image stylization has recently been proposed for transferring a natural image into a stylized one according to textual descriptions of the target…

计算机视觉与模式识别 · 计算机科学 2023-12-19 Nisha Huang , Yuxin Zhang , Fan Tang , Chongyang Ma , Haibin Huang , Yong Zhang , Weiming Dong , Changsheng Xu

Performance of deep learning algorithms decreases drastically if the data distributions of the training and testing sets are different. Due to variations in staining protocols, reagent brands, and habits of technicians, color variation in…

计算机视觉与模式识别 · 计算机科学 2020-12-01 Abhijeet Patil , Mohd. Talha , Aniket Bhatia , Nikhil Cherian Kurian , Sammed Mangale , Sunil Patel , Amit Sethi

Color inconsistency is an inevitable challenge in computational pathology, which generally happens because of stain intensity variations or sections scanned by different scanners. It harms the pathological image analysis methods, especially…

图像与视频处理 · 电气工程与系统科学 2022-03-01 Bingchao Zhao , Jiatai Lin , Changhong Liang , Zongjian Yi , Xin Chen , Bingbing Li , Weihao Qiu , Danyi Li , Li Liang , Chu Han , Zaiyi Liu

The color appearance of a pathological image is highly related to the imaging protocols, the proportion of different dyes, and the scanning devices. Computer-aided diagnostic systems may deteriorate when facing these color-variant…

图像与视频处理 · 电气工程与系统科学 2025-06-25 Zheng Chen

In practice, digital pathology images are often affected by various factors, resulting in very large differences in color and brightness. Stain normalization can effectively reduce the differences in color and brightness of digital…

图像与视频处理 · 电气工程与系统科学 2024-07-17 Hongtao Kang , Die Luo , Li Chen , Junbo Hu , Tingwei Quan , Shaoqun Zeng , Shenghua Cheng , Xiuli Liu

Computational histopathology image diagnosis becomes increasingly popular and important, where images are segmented or classified for disease diagnosis by computers. While pathologists do not struggle with color variations in slides,…

图像与视频处理 · 电气工程与系统科学 2020-07-27 Hanwen Liang , Konstantinos N. Plataniotis , Xingyu Li

In image processing, one of the most challenging tasks is to render an image's semantic meaning using a variety of artistic approaches. Existing techniques for arbitrary style transfer (AST) frequently experience mode-collapse,…

计算机视觉与模式识别 · 计算机科学 2024-08-08 Onkar Susladkar , Gayatri Deshmukh , Sparsh Mittal , Parth Shastri

Foundation models have revolutionized computational pathology by achieving remarkable success in high-level diagnostic tasks, yet the critical challenge of low-level image enhancement remains largely unaddressed. Real-world pathology images…

计算机视觉与模式识别 · 计算机科学 2025-09-03 Ziyi Liu , Zhe Xu , Jiabo Ma , Wenqaing Li , Junlin Hou , Fuxiang Huang , Xi Wang , Ronald Cheong Kin Chan , Terence Tsz Wai Wong , Hao Chen

Deep learning advances have revolutionized automated digital pathology analysis. However, differences in staining protocols and imaging conditions can introduce significant color variability. In deep learning, such color inconsistency often…

计算机视觉与模式识别 · 计算机科学 2025-10-09 Tianyue Xu , Yanlin Wu , Abhai K. Tripathi , Matthew M. Ippolito , Benjamin D. Haeffele

The rapid growth of digital pathology in recent years has provided an ideal opportunity for the development of artificial intelligence-based tools to improve the accuracy and efficiency of clinical diagnoses. One of the significant…

图像与视频处理 · 电气工程与系统科学 2024-03-08 Jack Breen , Kieran Zucker , Katie Allen , Nishant Ravikumar , Nicolas M. Orsi

Stain variation is a phenomenon observed when distinct pathology laboratories stain tissue slides that exhibit similar but not identical color appearance. Due to this color shift between laboratories, convolutional neural networks (CNNs)…

计算机视觉与模式识别 · 计算机科学 2020-04-16 David Tellez , Geert Litjens , Peter Bandi , Wouter Bulten , John-Melle Bokhorst , Francesco Ciompi , Jeroen van der Laak

Style transfer aims to fuse the artistic representation of a style image with the structural information of a content image. Existing methods train specific networks or utilize pre-trained models to learn content and style features.…

计算机视觉与模式识别 · 计算机科学 2024-10-22 Ying Hu , Chenyi Zhuang , Pan Gao

Deep image restoration models aim to learn a mapping from degraded image space to natural image space. However, they face several critical challenges: removing degradation, generating realistic details, and ensuring pixel-level consistency.…

计算机视觉与模式识别 · 计算机科学 2025-07-31 Xinqi Lin , Fanghua Yu , Jinfan Hu , Zhiyuan You , Wu Shi , Jimmy S. Ren , Jinjin Gu , Chao Dong
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