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Whole-slide images (WSIs) are an important data modality in computational pathology, yet their gigapixel resolution and lack of fine-grained annotations challenge conventional deep learning models. Multiple instance learning (MIL) offers a…

计算机视觉与模式识别 · 计算机科学 2025-12-22 Qian Zeng , Yihui Wang , Shu Yang , Yingxue Xu , Fengtao Zhou , Jiabo Ma , Dejia Cai , Zhengyu Zhang , Lijuan Qu , Yu Wang , Li Liang , Hao Chen

Computational pathology (CPath) has significantly advanced the clinical practice of pathology. Despite the progress made, Multiple Instance Learning (MIL), a promising paradigm within CPath, continues to face challenges, particularly…

计算机视觉与模式识别 · 计算机科学 2024-08-28 Yuqi Zhang , Xiaoqian Zhang , Jiakai Wang , Yuancheng Yang , Taiying Peng , Chao Tong

Recently, pathological diagnosis has achieved superior performance by combining deep learning models with the multiple instance learning (MIL) framework using whole slide images (WSIs). However, the giga-pixeled nature of WSIs poses a great…

计算机视觉与模式识别 · 计算机科学 2024-10-31 Zijie Fang , Yifeng Wang , Ye Zhang , Zhi Wang , Jian Zhang , Xiangyang Ji , Yongbing Zhang

Multiple instance learning (MIL) has become the leading approach for extracting discriminative features from whole slide images (WSIs) in computational pathology. Attention-based MIL methods can identify key patches but tend to overlook…

计算机视觉与模式识别 · 计算机科学 2025-09-30 Lubin Gan , Xiaoman Wu , Jing Zhang , Zhifeng Wang , Linhao Qu , Siying Wu , Xiaoyan Sun

Whole slide image (WSI) analysis heavily relies on multiple instance learning (MIL). While recent methods benefit from large-scale foundation models and advanced sequence modeling to capture long-range dependencies, they still struggle with…

图像与视频处理 · 电气工程与系统科学 2026-03-23 Lubin Gan , Jing Zhang , Heng Zhang , Xin Di , Zhifeng Wang , Wenke Huang , Xiaoyan Sun

Sequence modeling plays a vital role across various domains, with recurrent neural networks being historically the predominant method of performing these tasks. However, the emergence of transformers has altered this paradigm due to their…

Whole-slide image (WSI) analysis is challenging due to the gigapixel scale of slides and their inherent hierarchical multi-resolution structure. Existing multiple instance learning (MIL) approaches often model WSIs as unordered collections…

计算机视觉与模式识别 · 计算机科学 2026-03-09 Dongqing Xie , Yonghuang Wu

Multiple instance learning (MIL) is a robust paradigm for whole-slide pathological image (WSI) analysis, processing gigapixel-resolution images with slide-level labels. As pioneering efforts, attention-based MIL (ABMIL) and its variants are…

计算机视觉与模式识别 · 计算机科学 2024-04-02 Linghan Cai , Shenjin Huang , Ye Zhang , Jinpeng Lu , Yongbing Zhang

Whole slide images (WSIs) classification represents a fundamental challenge in computational pathology, where multiple instance learning (MIL) has emerged as the dominant paradigm. Current state-of-the-art (SOTA) MIL methods rely on…

计算机视觉与模式识别 · 计算机科学 2025-10-07 Chengying She , Chengwei Chen , Dongjie Fan , Lizhuang Liu , Chengwei Shao , Yun Bian , Ben Wang , Xinran Zhang

Histopathological whole slide image (WSI) analysis with deep learning has become a research focus in computational pathology. The current paradigm is mainly based on multiple instance learning (MIL), in which approaches with Transformer as…

计算机视觉与模式识别 · 计算机科学 2024-03-19 Hongbo Chu , Qiehe Sun , Jiawen Li , Yuxuan Chen , Lizhong Zhang , Tian Guan , Anjia Han , Yonghong He

State Space Models (SSMs), especially recent Mamba architecture, have achieved remarkable success in sequence modeling tasks. However, extending SSMs to computer vision remains challenging due to the non-sequential structure of visual data…

计算机视觉与模式识别 · 计算机科学 2026-03-23 Puskal Khadka , KC Santosh

Mamba, a recent selective structured state space model, excels in long sequence modeling, which is vital in the large model era. Long sequence modeling poses significant challenges, including capturing long-range dependencies within the…

计算机视觉与模式识别 · 计算机科学 2024-11-12 Rui Xu , Shu Yang , Yihui Wang , Yu Cai , Bo Du , Hao Chen

Foundation models, now powering most of the exciting applications in deep learning, are almost universally based on the Transformer architecture and its core attention module. Many subquadratic-time architectures such as linear attention,…

机器学习 · 计算机科学 2024-06-03 Albert Gu , Tri Dao

State space models (SSMs) with selection mechanisms and hardware-aware architectures, namely Mamba, have recently demonstrated significant promise in long-sequence modeling. Since the self-attention mechanism in transformers has quadratic…

计算机视觉与模式识别 · 计算机科学 2024-04-29 Hanwei Zhang , Ying Zhu , Dan Wang , Lijun Zhang , Tianxiang Chen , Zi Ye

Physics-informed machine learning (PIML) has emerged as a promising alternative to classical methods for predicting dynamical systems, offering faster and more generalizable solutions. However, existing models, including recurrent neural…

机器学习 · 计算机科学 2025-01-28 Zheyuan Hu , Nazanin Ahmadi Daryakenari , Qianli Shen , Kenji Kawaguchi , George Em Karniadakis

Whole Slide Image (WSI) analysis is pivotal in computational pathology, enabling cancer diagnosis by integrating morphological and architectural cues across magnifications. Multiple Instance Learning (MIL) serves as the standard framework…

计算机视觉与模式识别 · 计算机科学 2026-05-07 Sicheng Chen , Chad Wong , Tianyi Zhang , Enhui Chai , Zeyu Liu , Fei Xia

Multi-modal learning that combines pathological images with genomic data has significantly enhanced the accuracy of survival prediction. Nevertheless, existing methods have not fully utilized the inherent hierarchical structure within both…

计算机视觉与模式识别 · 计算机科学 2024-12-05 Ying Chen , Jiajing Xie , Yuxiang Lin , Yuhang Song , Wenxian Yang , Rongshan Yu

Recently, the state space model Mamba has demonstrated efficient long-sequence modeling capabilities, particularly for addressing long-sequence visual tasks in 3D medical imaging. However, existing generative self-supervised learning…

计算机视觉与模式识别 · 计算机科学 2025-05-15 Fenghe Tang , Bingkun Nian , Yingtai Li , Zihang Jiang , Jie Yang , Wei Liu , S. Kevin Zhou

This work presents Mamba Imitation Learning (MaIL), a novel imitation learning (IL) architecture that provides an alternative to state-of-the-art (SoTA) Transformer-based policies. MaIL leverages Mamba, a state-space model designed to…

Digitizing pathological images into gigapixel Whole Slide Images (WSIs) has opened new avenues for Computational Pathology (CPath). As positive tissue comprises only a small fraction of gigapixel WSIs, existing Multiple Instance Learning…

计算机视觉与模式识别 · 计算机科学 2025-09-16 Wenhao Tang , Sheng Huang , Heng Fang , Fengtao Zhou , Bo Liu , Qingshan Liu
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