相关论文: Experimental study of aerosol deposition in distal…
Pulmonary drug delivery systems rely on inhalation of drug-laden aerosols produced from aerosol generators such as inhalers, nebulizers etc. On deposition, the drug molecules diffuse in the mucus layer and are also subjected to mucociliary…
We study the transport and deposition of inhaled aerosols in a mid-generation, mucus-lined lung airway, with the aim of understanding if and how airborne particles can avoid the mucus and deposit on the airway wall -- an outcome that is…
For the one billion sufferers of respiratory disease, managing their disease with inhalers crucially influences their quality of life. Generic treatment plans could be improved with the aid of computational models that account for…
Could the microdroplets formed by viscoelastic stretching and break-up of mucosal liquids in the upper respiratory tract (URT), when inhaled further downwind, explain the brisk pace at which deep lung infections emerge following onset of…
Improving the efficacy of nasal sprays by enhancing targeted drug delivery to intra-airway tissue sites prone to infection onset is hypothesized to be achievable through an optimization of key device and formulation parameters, such as the…
Airway constriction and blockage in obstructive lung diseases cause ventilation heterogeneity and create barriers to effective drug deposition. Established computational particle-deposition models have not accounted for these impacts of…
Exhaled air contains aerosol of submicron droplets of the alveolar lining fluid (ALF), which are generated in the small airways of a human lung. Since the exhaled particles are micro-samples of the ALF, their trapping opens up an…
A new mathematical analysis of exhaled respiratory droplet dynamics and settling distances in the vicinity of vortical environments is presented. Recent experimental and theoretical studies suggest that vortical flow structures may enhance…
Inhalation directs air through a defined pathway, initiating from nostrils, moving through the main nasal cavity, past the pharynx and trachea, and culminating in the lungs. Inhaled particles, of a range of sizes, are ferried by this…
The big crux with drug delivery to human lungs is that the delivered dose at the local site of action is unpredictable and very difficult to measure, even a posteriori. It is highly subject-specific as it depends on lung morphology,…
COVID-19 pandemic has strikingly demonstrated how important it is to develop fundamental knowledge related to generation, transport and inhalation of pathogen-laden droplets and their subsequent possible fate as airborne particles, or…
Recent guidelines by WHO recommend delaying non-essential oral health care amid COVID-19 pandemic and call for research on aerosol generated during dental procedures. Thus, this study aims to assess the mechanisms of dental aerosol…
A model that predicts the outcome of collisions between droplets and particles in terms of the distribution of the droplet volume post-collision is lacking, in contrast to the case for droplet-droplet interactions. Taking existing models…
Aerosolized droplets play a central role in the transmission of various infectious diseases, including Legionnaire's disease, gastroenteritis-causing norovirus, and most recently COVID-19. Respiratory droplets are known to be the most…
Inhalers spray over 100 million drug particles into the mouth, where a significant portion of the drug may deposit. Understanding how the complex interplay between particle and solid phases influence deposition is crucial for optimising…
To evaluate the role of common substrates in the transmission of respiratory viruses, uniformly distributed microdroplets of artificial saliva were generated using an advanced inkjet printing technology to replicate the aerosol droplets,…
Rotating fans are the prevalent forced cooling method for heat generating equipment and buildings. As the concentration of atmospheric pollutants has increased, the accumulation of microscale and nanoscale particles on surfaces due to…
We study the surface growth generated by the random deposition of particles of different sizes. A model is proposed where the particles are aggregated on an initially flat surface, giving rise to a rough interface and a porous bulk. By…
Introduction: Topical intranasal drugs are widely prescribed for Chronic Rhinosinusitis (CRS), although delivery can vary with device type and droplet size. The study objective was to compare nebulized and sprayed droplet deposition in the…
Localized vortices can have significant influence on transport of inhaled particles through the upper respiratory tract. These vortices have complex three-dimensional structure with details dependent on the anatomical geometry. Using a…