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Trained on massive cross-species DNA corpora, DNA large language models (LLMs) learn the fundamental "grammar" and evolutionary patterns of genomic sequences. This makes them powerful priors for DNA sequence modeling, particularly over long…

基因组学 · 定量生物学 2025-11-19 Rui Zhu , Xiaopu Zhou , Haixu Tang , Stephen W. Scherer , Lucila Ohno-Machado

Achieving high-performing language models which include medium- and lower-resource languages remains a challenge. Massively multilingual models still underperform compared to language-specific adaptations, especially at smaller model…

计算与语言 · 计算机科学 2025-12-12 Kevin Glocker , Kätriin Kukk , Romina Oji , Marcel Bollmann , Marco Kuhlmann , Jenny Kunz

Reinforcement learning has proven effective for enhancing multi-step reasoning in large language models (LLMs), yet its benefits have not fully translated to multilingual contexts. Existing methods struggle with a fundamental trade-off:…

计算与语言 · 计算机科学 2026-05-22 Yuchun Fan , Bei Li , Peiguang Li , Yilin Wang , Yongyu Mu , Jian Yang , Xin Chen , Rongxiang Weng , Jingang Wang , Xunliang Cai , Jingbo Zhu , Tong Xiao

Domain adaptation in natural language generation (NLG) remains challenging because of the high complexity of input semantics across domains and limited data of a target domain. This is particularly the case for dialogue systems, where we…

计算与语言 · 计算机科学 2019-10-16 Bo-Hsiang Tseng , Paweł Budzianowski , Yen-Chen Wu , Milica Gašić

In the evolving landscape of conversational AI, generating concise, context-aware, and human-like dialogue using small and medium-sized language models (LLMs) remains a complex challenge. This study investigates the influence of LoRA rank,…

计算与语言 · 计算机科学 2025-04-15 Chitranshu Harbola , Anupam Purwar

Fine-tuning large language models is a popular choice among users trying to adapt them for specific applications. However, fine-tuning these models is a demanding task because the user has to examine several factors, such as resource…

机器学习 · 计算机科学 2024-06-07 Arjun Singh , Nikhil Pandey , Anup Shirgaonkar , Pavan Manoj , Vijay Aski

Gene finding is the task of identifying the locations of coding sequences within the vast amount of genetic code contained in the genome. With an ever increasing quantity of raw genome sequences, gene finding is an important avenue towards…

基因组学 · 定量生物学 2025-05-07 Frederikke I. Marin , Dennis Pultz , Wouter Boomsma

The dynamic nature of language, particularly evident in the realm of slang and memes on the Internet, poses serious challenges to the adaptability of large language models (LLMs). Traditionally anchored to static datasets, these models…

计算与语言 · 计算机科学 2025-02-04 Lingrui Mei , Shenghua Liu , Yiwei Wang , Baolong Bi , Xueqi Cheng

Fine-tuning is a promising technique for leveraging Transformer-based language models in downstream tasks. As model sizes continue to grow, updating all model parameters becomes increasingly costly. Parameter-efficient fine-tuning methods…

计算与语言 · 计算机科学 2025-06-27 Xiaoshuang Ji , Zhendong Zhao , Xiaojun Chen , Xin Zhao , Zeyao Liu

Alignment is a crucial step to enhance the instruction-following and conversational abilities of language models. Despite many recent work proposing new algorithms, datasets, and training pipelines, there is a lack of comprehensive studies…

计算与语言 · 计算机科学 2024-10-04 Xiao Yu , Qingyang Wu , Yu Li , Zhou Yu

Rich textual and topological information of textual graphs need to be modeled in real-world applications such as webpages, e-commerce, and academic articles. Practitioners have been long following the path of adopting a shallow text encoder…

计算与语言 · 计算机科学 2024-07-25 Yun Zhu , Yaoke Wang , Haizhou Shi , Siliang Tang

Consistency is a key requirement of high-quality translation. It is especially important to adhere to pre-approved terminology and adapt to corrected translations in domain-specific projects. Machine translation (MT) has achieved…

计算与语言 · 计算机科学 2024-01-29 Yasmin Moslem

Large pretrained language models (PLMs) are often domain- or task-adapted via fine-tuning or prompting. Finetuning requires modifying all of the parameters and having enough data to avoid overfitting while prompting requires no training and…

计算与语言 · 计算机科学 2022-07-11 Zejiang Hou , Julian Salazar , George Polovets

Integrating large language models (LLMs) with knowledge graphs derived from domain-specific data represents an important advancement towards more powerful and factual reasoning. As these models grow more capable, it is crucial to enable…

人工智能 · 计算机科学 2024-04-19 Stefan Dernbach , Khushbu Agarwal , Alejandro Zuniga , Michael Henry , Sutanay Choudhury

Large language models (LLMs) have significantly advanced natural language processing, excelling in areas like text generation, summarization, and question-answering. Despite their capabilities, these models face challenges when fine-tuned…

计算与语言 · 计算机科学 2024-12-23 Ali Hamdi , Hozaifa Kassab , Mohamed Bahaa , Marwa Mohamed

Genomic language models (gLMs) have shown mostly modest success in identifying evolutionarily constrained elements in mammalian genomes. To address this issue, we introduce a novel framework for training gLMs that explicitly models…

基因组学 · 定量生物学 2026-03-23 Carlos Albors , Jianan Canal Li , Gonzalo Benegas , Chengzhong Ye , Yun S. Song

The integration of contextual embeddings into the optimization processes of large language models is an advancement in natural language processing. The Context-Aware Neural Gradient Mapping framework introduces a dynamic gradient adjustment…

计算与语言 · 计算机科学 2025-04-25 David Boldo , Lily Pemberton , Gabriel Thistledown , Jacob Fairchild , Felix Kowalski

The lack of out-of-domain generalization is a critical weakness of deep networks for semantic segmentation. Previous studies relied on the assumption of a static model, i. e., once the training process is complete, model parameters remain…

计算机视觉与模式识别 · 计算机科学 2024-09-04 Sherwin Bahmani , Oliver Hahn , Eduard Zamfir , Nikita Araslanov , Daniel Cremers , Stefan Roth

Self-supervised learning has emerged as a key approach for learning generic representations from speech data. Despite promising results in downstream tasks such as speech recognition, speaker verification, and emotion recognition, a…

计算与语言 · 计算机科学 2024-08-01 Nakamasa Inoue , Shinta Otake , Takumi Hirose , Masanari Ohi , Rei Kawakami

Neural machine translation often adopts the fine-tuning approach to adapt to specific domains. However, nonrestricted fine-tuning can easily degrade on the general domain and over-fit to the target domain. To mitigate the issue, we propose…

计算与语言 · 计算机科学 2021-03-29 Jianze Liang , Chengqi Zhao , Mingxuan Wang , Xipeng Qiu , Lei Li