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Large Language Models (LLMs) have swiftly emerged as vital resources for different applications in the biomedical and healthcare domains; however, these models encounter issues such as generating inaccurate information or hallucinations.…

计算与语言 · 计算机科学 2024-05-06 Mingchen Li , Halil Kilicoglu , Hua Xu , Rui Zhang

Objective: Electronic health records (EHR) data are prone to missingness and errors. Previously, we devised an "enriched" chart review protocol where a "roadmap" of auxiliary diagnoses (anchors) was used to recover missing values in EHR…

In recent years, accurately and quickly deploying medical large language models (LLMs) has become a trend. Among these, retrieval-augmented generation (RAG) has garnered attention due to rapid deployment and privacy protection. However, the…

计算与语言 · 计算机科学 2025-08-06 Penglei Sun , Yixiang Chen , Xiang Li , Xiaowen Chu

While pioneering deep learning methods have made great strides in analyzing electronic health record (EHR) data, they often struggle to fully capture the semantics of diverse medical codes from limited data. The integration of external…

机器学习 · 计算机科学 2024-08-26 Zhihao Yu , Yujie Jin , Yongxin Xu , Xu Chu , Yasha Wang , Junfeng Zhao

In-hospital mortality (IHM) prediction for ICU patients is critical for timely interventions and efficient resource allocation. While structured physiological data provides quantitative insights, clinical notes offer unstructured,…

计算与语言 · 计算机科学 2024-11-27 Harshavardhan Battula , Jiacheng Liu , Jaideep Srivastava

Medical vision-language models (VLMs) achieve strong performance in diagnostic reporting and image-text alignment, yet their underlying reasoning mechanisms remain fundamentally correlational, exhibiting reliance on superficial statistical…

机器学习 · 计算机科学 2026-01-27 Weiqin Yang , Haowen Xue , Qingyi Peng , Hexuan Hu , Qian Huang , Tingbo Zhang

Large language models (LLMs) has become a significant research focus and is utilized in various fields, such as text generation and dialog systems. One of the most essential applications of LLM is Retrieval Augmented Generation (RAG), which…

计算与语言 · 计算机科学 2025-10-06 Sicheng Dong , Vahid Zolfaghari , Nenad Petrovic , Alois Knoll

Due to the increasing adoption of electronic health records (EHR), large scale EHRs have become another rich data source for translational clinical research. Despite its potential, deriving generalizable knowledge from EHR data remains…

机器学习 · 统计学 2023-06-01 Junwei Lu , Jin Yin , Tianxi Cai

Many diagnostic errors occur because clinicians cannot easily access relevant information in patient Electronic Health Records (EHRs). In this work we propose a method to use LLMs to identify pieces of evidence in patient EHR data that…

Deep learning models exhibit state-of-the-art performance for many predictive healthcare tasks using electronic health records (EHR) data, but these models typically require training data volume that exceeds the capacity of most healthcare…

机器学习 · 计算机科学 2018-10-24 Edward Choi , Cao Xiao , Walter F. Stewart , Jimeng Sun

Large Language Models (LLMs) showcase impressive capabilities but encounter challenges like hallucination, outdated knowledge, and non-transparent, untraceable reasoning processes. Retrieval-Augmented Generation (RAG) has emerged as a…

计算与语言 · 计算机科学 2024-03-28 Yunfan Gao , Yun Xiong , Xinyu Gao , Kangxiang Jia , Jinliu Pan , Yuxi Bi , Yi Dai , Jiawei Sun , Meng Wang , Haofen Wang

Clinical note generation aims to produce free-text summaries of a patient's condition and diagnostic process, with discharge instructions being a representative long-form example. While recent LLM-based methods pre-trained on general…

计算与语言 · 计算机科学 2025-08-12 Lo Pang-Yun Ting , Chengshuai Zhao , Yu-Hua Zeng , Yuan Jee Lim , Kun-Ta Chuang , Huan Liu

Large language models (LLMs) offer new opportunities for constructing knowledge graphs (KGs) from unstructured clinical narratives. However, existing approaches often rely on structured inputs and lack robust validation of factual accuracy…

人工智能 · 计算机科学 2026-01-06 Udiptaman Das , Krishnasai B. Atmakuri , Duy Ho , Chi Lee , Yugyung Lee

Evidence-based medicine (EBM) holds a crucial role in clinical application. Given suitable medical articles, doctors effectively reduce the incidence of misdiagnoses. Researchers find it efficient to use large language models (LLMs)…

计算与语言 · 计算机科学 2025-11-07 Mengzhou Sun , Sendong Zhao , Jianyu Chen , Haochun Wang , Bing Qin

Retrieval-augmented generation (RAG) has proven effective in integrating knowledge into large language models (LLMs). However, conventional RAGs struggle to capture complex relationships between pieces of knowledge, limiting their…

信息检索 · 计算机科学 2025-12-12 Linhao Luo , Zicheng Zhao , Gholamreza Haffari , Dinh Phung , Chen Gong , Shirui Pan

Retrieval-augmented generation (RAG) is a paradigm that augments large language models (LLMs) with external knowledge to tackle knowledge-intensive question answering. While several benchmarks evaluate Multimodal LLMs (MLLMs) under…

计算与语言 · 计算机科学 2025-08-18 Yin Wu , Quanyu Long , Jing Li , Jianfei Yu , Wenya Wang

Automated radiology report generation (RRG) holds potential to reduce the workload of radiologists, and recent advances in multimodal large language models (MLLMs) have enabled multimodal chest X-ray (CXR) report generation. However,…

计算机视觉与模式识别 · 计算机科学 2026-04-21 Jonggwon Park , Byungmu Yoon , Soobum Kim , Kyoyun Choi

The rapid growth of electronic health record (EHR) datasets opens up promising opportunities to understand human diseases in a systematic way. However, effective extraction of clinical knowledge from the EHR data has been hindered by its…

机器学习 · 计算机科学 2022-06-06 Yuesong Zou , Ahmad Pesaranghader , Aman Verma , David Buckeridge , Yue Li

Large language models (LLMs) are transforming the landscape of medicine, yet two fundamental challenges persist: keeping up with rapidly evolving medical knowledge and providing verifiable, evidence-grounded reasoning. Retrieval-augmented…

Large language models (LLMs) in biomedicine face a fundamental conflict between static parameter knowledge and the dynamic nature of clinical evidence. Retrieval-Augmented Generation (RAG) addresses this by grounding generation in external…

其他定量生物学 · 定量生物学 2025-12-19 Jiawei He , Boya Zhang , Hossein Rouhizadeh , Yingjian Chen , Rui Yang , Jin Lu , Xudong Chen , Nan Liu , Douglas Teodoro