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Despite advances in surgical techniques and care, postoperative complications are prevalent and effects up to 15% of the patients who underwent a major surgery. The objective of this study is to develop and validate models for predicting…

Chronic kidney disease (CKD) affects millions worldwide and progresses irreversibly through stages culminating in end-stage renal disease (ESRD) and death. Outcome trials in CKD traditionally employ time-to-first-event analyses using the…

统计方法学 · 统计学 2026-01-27 Jiren Sun , Tuo Wang , Yu Du

Background: Hypertensive kidney disease (HKD) patients in intensive care units (ICUs) face high short-term mortality, but tailored risk prediction tools are lacking. Early identification of high-risk individuals is crucial for clinical…

机器学习 · 计算机科学 2025-07-28 Yong Si , Junyi Fan , Li Sun , Shuheng Chen , Minoo Ahmadi , Elham Pishgar , Kamiar Alaei , Greg Placencia , Maryam Pishgar

Machine learning models for chronic kidney disease (CKD) risk prediction often post strong discrimination scores on internal test sets. Calibration and uncertainty quantification get far less attention, leaving clinicians without reliable…

机器学习 · 计算机科学 2026-05-22 Michael O. Eniolade

Kidney abnormality detection is required for all preclinical drug development. It involves a time-consuming and costly examination of hundreds to thousands of whole-slide images per drug safety study, most of which are normal, to detect any…

计算机视觉与模式识别 · 计算机科学 2025-09-03 Ivan Slootweg , Natalia P. García-De-La-Puente , Geert Litjens , Salma Dammak

Deep learning (DL) can aid doctors in detecting worsening patient states early, affording them time to react and prevent bad outcomes. While DL-based early warning models usually work well in the hospitals they were trained for, they tend…

Acute pancreatitis (AP) is a common and potentially life-threatening gastrointestinal disease that imposes a significant burden on healthcare systems. ICU readmissions among AP patients are common, especially in severe cases, with rates…

应用统计 · 统计学 2025-05-22 Shuheng Chen , Yong Si , Junyi Fan , Li Sun , Elham Pishgar , Kamiar Alaei , Greg Placencia , Maryam Pishgar

Background: Major postoperative complications are associated with increased short and long-term mortality, increased healthcare cost, and adverse long-term consequences. The large amount of data contained in the electronic health record…

Knee Osteoarthritis (OA) is a common musculoskeletal disorder in the United States. When diagnosed at early stages, lifestyle interventions such as exercise and weight loss can slow OA progression, but at later stages, only an invasive…

图像与视频处理 · 电气工程与系统科学 2020-02-26 Aniket A. Tolpadi , Jinhee J. Lee , Valentina Pedoia , Sharmila Majumdar

The optimal moment to start renal replacement therapy in a patient with acute kidney injury (AKI) remains a challenging problem in intensive care nephrology. Multiple randomised controlled trials have tried to answer this question, but…

Background: Vancomycin, a key antibiotic for severe Gram-positive infections in ICUs, poses a high nephrotoxicity risk. Early prediction of kidney injury in critically ill patients is challenging. This study aimed to develop a machine…

机器学习 · 计算机科学 2025-08-01 Junyi Fan , Li Sun , Shuheng Chen , Yong Si , Minoo Ahmadi , Greg Placencia , Elham Pishgar , Kamiar Alaei , Maryam Pishgar

Acute Kidney Injury (AKI) is a frequent complication in critically ill patients, affecting up to 50% of patients in the intensive care units. The lack of standardized and open-source tools for applying the Kidney Disease Improving Global…

Kidney cancer is a global health concern, and accurate assessment of patient frailty is crucial for optimizing surgical outcomes. This paper introduces AI Age Discrepancy, a novel metric derived from machine learning analysis of…

Background: Sepsis-Associated Acute Kidney Injury (SA-AKI) leads to high mortality in intensive care. This study develops machine learning models using the Medical Information Mart for Intensive Care IV (MIMIC-IV) database to predict…

机器学习 · 计算机科学 2025-05-20 Shuheng Chen , Junyi Fan , Elham Pishgar , Kamiar Alaei , Greg Placencia , Maryam Pishgar

Objective: To compare different deep learning architectures for predicting the risk of readmission within 30 days of discharge from the intensive care unit (ICU). The interpretability of attention-based models is leveraged to describe…

Patients with Acute Kidney Injury (AKI) increase mortality, morbidity, and long-term adverse events. Therefore, early identification of AKI may improve renal function recovery, decrease comorbidities, and further improve patients' survival.…

应用统计 · 统计学 2020-07-08 Bowen Kuo , Yihuang Kang , Pinghsung Wu , Sheng-Tai Huang , Yajie Huang

Kidney abnormality segmentation has important potential to enhance the clinical workflow, especially in settings requiring quantitative assessments. Kidney volume could serve as an important biomarker for renal diseases, with changes in…

Several algorithms for learning the structure of dynamic Bayesian networks (DBNs) require an a priori ordering of variables, which influences the determined graph topology. However, it is often unclear how to determine this order if feature…

Predicting the risk of mortality for patients with acute myocardial infarction (AMI) using electronic health records (EHRs) data can help identify risky patients who might need more tailored care. In our previous work, we built…

机器学习 · 计算机科学 2019-04-30 Seyedeh Neelufar Payrovnaziri , Laura A. Barrett , Daniel Bis , Jiang Bian , Zhe He

The current best practice approach for the retrospective diagnosis of adverse drug events (ADEs) in hospitalized patients relies on a full patient chart review and a formal causality assessment by multiple medical experts. This evaluation…