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Recently, the impressive performance of large language models (LLMs) on a wide range of tasks has attracted an increasing number of attempts to apply LLMs in drug discovery. However, molecule optimization, a critical task in the drug…

定量方法 · 定量生物学 2024-01-22 Geyan Ye , Xibao Cai , Houtim Lai , Xing Wang , Junhong Huang , Longyue Wang , Wei Liu , Xiangxiang Zeng

Large language models (LLMs) have been applied to tasks in healthcare, ranging from medical exam questions to responding to patient questions. With increasing institutional partnerships between companies producing LLMs and healthcare…

计算与语言 · 计算机科学 2024-04-10 Jesutofunmi A. Omiye , Haiwen Gui , Shawheen J. Rezaei , James Zou , Roxana Daneshjou

Large language models (LLMs) have become increasingly prevalent in our daily lives, leading to an expectation for LLMs to be trustworthy -- - both accurate and well-calibrated (the prediction confidence should align with its ground truth…

计算与语言 · 计算机科学 2024-10-04 KaShun Shum , Minrui Xu , Jianshu Zhang , Zixin Chen , Shizhe Diao , Hanze Dong , Jipeng Zhang , Muhammad Omer Raza

The emergence of advanced reasoning capabilities in Large Language Models (LLMs) marks a transformative development in healthcare applications. Beyond merely expanding functional capabilities, these reasoning mechanisms enhance decision…

人工智能 · 计算机科学 2025-08-27 Armin Berger , Sarthak Khanna , David Berghaus , Rafet Sifa

Large Language Models (LLMs) have emerged as powerful candidates to inform clinical decision-making processes. While these models play an increasingly prominent role in shaping the digital landscape, two growing concerns emerge in…

计算与语言 · 计算机科学 2024-04-24 Raphael Poulain , Hamed Fayyaz , Rahmatollah Beheshti

Importance: We introduce a novel Retrieval Augmented Generation (RAG)-Large Language Model (LLM) framework as a Clinical Decision Support Systems (CDSS) to support safe medication prescription. Objective: To evaluate the efficacy of…

Large Language Models (LLMs) have become valuable assets in mental health, showing promise in both classification tasks and counseling applications. This paper offers a perspective on using LLMs in mental health applications. It discusses…

计算与语言 · 计算机科学 2023-12-19 Shaoxiong Ji , Tianlin Zhang , Kailai Yang , Sophia Ananiadou , Erik Cambria

Artificial Intelligence (AI) has increasingly influenced modern society, recently in particular through significant advancements in Large Language Models (LLMs). However, high computational and storage demands of LLMs still limit their…

计算与语言 · 计算机科学 2025-04-23 Daniel Hendriks , Philipp Spitzer , Niklas Kühl , Gerhard Satzger

The proliferation of Large Language Models (LLMs) in medicine has enabled impressive capabilities, yet a critical gap remains in their ability to perform systematic, transparent, and verifiable reasoning, a cornerstone of clinical practice.…

计算与语言 · 计算机科学 2025-08-04 Wenxuan Wang , Zizhan Ma , Meidan Ding , Shiyi Zheng , Shengyuan Liu , Jie Liu , Jiaming Ji , Wenting Chen , Xiang Li , Linlin Shen , Yixuan Yuan

Leveraging Large Language Models as Recommenders (LLMRec) has gained significant attention and introduced fresh perspectives in user preference modeling. Existing LLMRec approaches prioritize text semantics, usually neglecting the valuable…

信息检索 · 计算机科学 2025-06-17 Yang Zhang , Fuli Feng , Jizhi Zhang , Keqin Bao , Qifan Wang , Xiangnan He

Recent developments in large language models (LLMs) have unlocked new opportunities for healthcare, from information synthesis to clinical decision support. These new LLMs are not just capable of modeling language, but can also act as…

In this study, we propose a structured methodology that utilizes large language models (LLMs) in a cost-efficient and parsimonious manner, integrating the strengths of scholars and machines while offsetting their respective weaknesses. Our…

计算与语言 · 计算机科学 2025-12-30 Navid Asgari , Benjamin M. Cole

Automatic disease diagnosis has become increasingly valuable in clinical practice. The advent of large language models (LLMs) has catalyzed a paradigm shift in artificial intelligence, with growing evidence supporting the efficacy of LLMs…

The distillation of knowledge from Large Language Models (LLMs) into Smaller Language Models (SLMs), preserving the capabilities and performance of LLMs while reducing model size, has played a key role in the proliferation of LLMs. Because…

计算与语言 · 计算机科学 2025-07-14 Henry J. Xie , Jinghan Zhang , Xinhao Zhang , Kunpeng Liu

Tabular data synthesis is crucial in machine learning, yet existing general methods-primarily based on statistical or deep learning models-are highly data-dependent and often fall short in recommender systems. This limitation arises from…

信息检索 · 计算机科学 2025-02-12 Jingtong Gao , Zhaocheng Du , Xiaopeng Li , Yichao Wang , Xiangyang Li , Huifeng Guo , Ruiming Tang , Xiangyu Zhao

Large language models (LLMs) have recently been used as backbones for recommender systems. However, their performance often lags behind conventional methods in standard tasks like retrieval. We attribute this to a mismatch between LLMs'…

As software grows in complexity to accommodate diverse features and platforms, software bloating has emerged as a significant challenge, adversely affecting performance and security. However, existing approaches inadequately address the…

软件工程 · 计算机科学 2025-03-13 Bo Lin , Shangwen Wang , Yihao Qin , Liqian Chen , Xiaoguang Mao

In recent years, there has been an explosion of interest in the applications of large pre-trained language models (PLMs) to recommender systems, with many studies showing strong performance of PLMs on common benchmark datasets. PLM-based…

信息检索 · 计算机科学 2025-06-23 Kevin Foley , Shaghayegh Agah , Kavya Priyanka Kakinada

Recommender systems utilizing explicit feedback have witnessed significant advancements and widespread applications over the past years. However, generating recommendations in few-shot scenarios remains a persistent challenge. Recently,…

信息检索 · 计算机科学 2023-12-22 Zhoumeng Wang

Large Language Models (LLMs) have demonstrated exceptional capabilities across various machine learning (ML) tasks. Given the high costs of creating annotated datasets for supervised learning, LLMs offer a valuable alternative by enabling…

计算与语言 · 计算机科学 2024-08-23 Meiyun Wang , Masahiro Suzuki , Hiroki Sakaji , Kiyoshi Izumi