相关论文: Deep Tissue Sensing of Chiral Molecules using Pola…
In the close vicinity of a chiral nanostructure, the circular dichroism of a biomolecule could be greatly enhanced, due to the interaction with the local superchiral fields. Modest enhancement of optical activity using a planar…
Sensing chirality is of fundamental importance to many fields, including analytical and biological chemistry, pharmacology, and fundamental physics. Recent developments have extended optical chiral sensing using microwaves, fs pulses,…
Several centimeters below the skin lie multiple biomarkers, such as glucose, oxygenation, and blood flow. Monitoring these biomarkers regularly and in a non-invasive manner would enable early insight into metabolic status and vascular…
This work presents a quantum-limited optomechanical sensing platform for real-time detection and discrimination of chiral molecules, based on a multilayer hybrid plasmonic-mechanical resonator. Leveraging quantum zero-point motion and…
Chiral spectroscopy is a powerful technique that enables to identify the chirality of matter through optical means. So far, experiments to check the chirality of matter or nanostructures have been carried out using free-space propagating…
Strong enhancement of molecular circular dichroism has the potential to enable efficient asymmetric photolysis, a method of chiral separation that has conventionally been impeded by insufficient yield and low enantiomeric excess. Here, we…
Nanophotonic platforms in theory uniquely enable < femtomoles of chiral biological and pharmaceutical molecules to be detected, through the highly localised changes in the chiral asymmetries of the near-fields that they induce. However,…
Metasurfaces, the two-dimensional analogues of metamaterials, are ideal platforms for sensing molecular chirality at the nanoscale, e.g. of inclusions of natural optically active molecules, as they offer large accessible areas (they are…
Optically active achiral metasurfaces offer a promising way to detect chiral molecules based on chiroptic methods. The combination of plasmonic enhanced circular dichroism and reversible optical activity would boost the sensitivity and…
Chiroptical enantioselective sensing is gaining traction across various applications. However, intrinsic molecular chiroptical responses are weak, and existing amplification approaches add synthesis, manufacturing, or operational complexity…
Circular Dichroism (CD) can distinguish the handedness of chiral molecules. However, it is typically very weak due to vanishing absorption at low molecular concentrations. Here, we suggest Thermal Circular Dichroism (TCD) for chiral…
Circular dichroism spectroscopy is an essential technique for understanding molecular structure and magnetic materials, but spatial resolution is limited by the wavelength of light, and sensitivity sufficient for single-molecule…
The enhancement of the inherently weak optical activity of solvated molecules by superchiral fields, crucial for detecting their chirality, is a research frontier of photonics and the basis of novel chiroptical detection schemes. Here, we…
The detection and discrimination of molecular chirality are essential for advancing pharmaceutical and biological applications. While nanophotonic platforms offer a route to enhance chiral light-matter interactions, existing device concepts…
We investigate the potential of surface plasmon polaritons at noble metal interfaces for surface-enhanced chiroptical sensing of dilute chiral drug solutions. The high quality factor of surface plasmon resonances in both Otto and…
Chirality is ubiquitous in nature and fundamental in science, from particle physics to metamaterials.The most established technique of chiral discrimination - photoabsorption circular dichroism - relies on the magnetic properties of a…
Chiral discrimination of enantiomeric biomolecules is vital in chemistry, biology, and medicine. Conventional methods, relying on circularly polarized light, face weak chiroptical signals and potential photodamage. Despite extensive efforts…
Highly sensitive and selective label free devices for real-time identification of specific biomarkers are expected to significantly impact the biosensing field. The ability of plasmonic systems to confine the light in nanometer volume and…
Molecular chirality plays an important role in chemistry and biology, allows control of biological interactions, affects drugs efficacy and safety, and promotes synthesis of new materials. In general, chirality manifests itself in optical…
The interaction between chiral molecules and circularly polarized light is largely influenced by the local optical chirality density. This interaction prompts substantial demand of the design of nanophotonic platforms capable of enhancing…