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High-throughput sequencing (HTS) is revolutionizing biological research by enabling scientists to quickly and cheaply query variation at a genomic scale. Despite the increasing ease of obtaining such data, using these data effectively still…

基因组学 · 定量生物学 2012-11-09 Sonal Singhal

Automatic design of organic materials requires black-box optimization in a vast chemical space. In conventional molecular design algorithms, a molecule is built as a combination of predetermined fragments. Recently, deep neural network…

化学物理 · 物理学 2018-06-27 Xiufeng Yang , Jinzhe Zhang , Kazuki Yoshizoe , Kei Terayama , Koji Tsuda

Degree-based graph construction is an ubiquitous problem in network modeling, ranging from social sciences to chemical compounds and biochemical reaction networks in the cell. This problem includes existence, enumeration, exhaustive…

We extend the decomposition approach for learning Bayesian networks (BNs) proposed by (Xie et. al.) to learning multivariate regression chain graphs (MVR CGs), which include BNs as a special case. The same advantages of this decomposition…

人工智能 · 计算机科学 2020-02-26 Mohammad Ali Javidian , Marco Valtorta

Processing large complex networks recently attracted considerable interest. Complex graphs are useful in a wide range of applications from technological networks to biological systems like the human brain. Sometimes these networks are…

数据结构与算法 · 计算机科学 2019-12-03 Christian Schulz

Real-world graphs, such as social networks, financial transactions, and recommendation systems, often demonstrate dynamic behavior. This phenomenon, known as graph stream, involves the dynamic changes of nodes and the emergence and…

机器学习 · 计算机科学 2023-05-16 Yanping Zheng , Zhewei Wei , Jiajun Liu

We present a new scalable, lightweight algorithm to incrementally construct the BWT and FM-index of large string sets such as those produced by Next Generation Sequencing. The algorithm is designed for massive parallelism and can…

数据结构与算法 · 计算机科学 2014-10-03 Jacopo Pantaleoni

Modern machine learning workloads use large models, with complex structures, that are very expensive to execute. The devices that execute complex models are becoming increasingly heterogeneous as we see a flourishing of domain-specific…

机器学习 · 计算机科学 2020-11-02 Jakub Tarnawski , Amar Phanishayee , Nikhil R. Devanur , Divya Mahajan , Fanny Nina Paravecino

Driven by the increasing volume of recorded data, the demand for simulation from experiments based at the Large Hadron Collider will rise sharply in the coming years. Addressing this demand solely with existing computationally intensive…

Graph kernels are often used in bioinformatics and network applications to measure the similarity between graphs; therefore, they may be used to construct efficient graph classifiers. Many graph kernels have been developed thus far, but to…

量子物理 · 物理学 2022-11-01 Kaito Kishi , Takahiko Satoh , Rudy Raymond , Naoki Yamamoto , Yasubumi Sakakibara

Graph Convolutional Network (GCN) has been widely used in graph learning tasks. However, GCN-based models (GCNs) is an inherently coupled training framework repetitively conducting the complex neighboring aggregation, which leads to the…

机器学习 · 计算机科学 2020-07-23 Dalong Yang , Chuan Chen , Youhao Zheng , Zibin Zheng , Shih-wei Liao

Next-generation sequencing (NGS) is a pivotal technique in genome sequencing due to its high throughput, rapid results, cost-effectiveness, and enhanced accuracy. Its significance extends across various domains, playing a crucial role in…

基因组学 · 定量生物学 2025-04-28 Fathima Nuzla Ismail , Shanika Amarasoma

In the area of large-scale training of graph embeddings, effective training frameworks and partitioning methods are critical for handling large networks. However, they face two major challenges: 1) existing synchronized distributed…

机器学习 · 计算机科学 2024-09-17 Yuhe Bai , Camelia Constantin , Hubert Naacke

We propose Slim Graph: the first programming model and framework for practical lossy graph compression that facilitates high-performance approximate graph processing, storage, and analytics. Slim Graph enables the developer to express…

数据结构与算法 · 计算机科学 2021-08-04 Maciej Besta , Simon Weber , Lukas Gianinazzi , Robert Gerstenberger , Andrey Ivanov , Yishai Oltchik , Torsten Hoefler

The adaptive processing of structured data is a long-standing research topic in machine learning that investigates how to automatically learn a mapping from a structured input to outputs of various nature. Recently, there has been an…

机器学习 · 计算机科学 2022-02-28 Federico Errica

The discovery of peptides having high biological activity is very challenging mainly because there is an enormous diversity of compounds and only a minority have the desired properties. To lower cost and reduce the time to obtain promising…

In the modern age of social media and networks, graph representations of real-world phenomena have become an incredibly useful source to mine insights. Often, we are interested in understanding how entities in a graph are interconnected.…

机器学习 · 计算机科学 2021-12-16 Aneesh Komanduri , Justin Zhan

Structural clustering is one of the most popular graph clustering methods, which has achieved great performance improvement by utilizing GPUs. Even though, the state-of-the-art GPU-based structural clustering algorithm, GPUSCAN, still…

数据库 · 计算机科学 2023-12-01 Long Yuan , Zeyu Zhou , Xuemin Lin , Zi Chen , Xiang Zhao , Fan Zhang

The de novo assembly of large, complex genomes is a significant challenge with currently available DNA sequencing technology. While many de novo assembly software packages are available, comparatively little attention has been paid to…

基因组学 · 定量生物学 2013-07-31 Jared T. Simpson

We extend our previous algorithm that generates all labeled graphs with a given graphical degree sequence to generate all labeled triangle-free graphs with a given graphical degree sequence. The algorithm uses various pruning techniques to…

组合数学 · 数学 2026-01-23 Kai Wang