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Although species longevity is subject to a diverse range of selective forces, the mortality curves of a wide variety of organisms are rather similar. We argue that aging and its universal characteristics may have evolved by means of a…

种群与进化 · 定量生物学 2013-02-01 Dervis Can Vural , Greg Morrison , L. Mahadevan

Aging is thought to be a consequence of intrinsic breakdowns in how genetic information is processed. But mounting experimental evidence suggests that aging can be slowed. To help resolve this mystery, I derive a mortality equation which…

种群与进化 · 定量生物学 2022-09-01 Thomas Fink

Aging is a fundamental aspect of living systems that undergo a progressive deterioration of physiological function with age and an increase of vulnerability to disease and death. Living systems, known as complex systems, require complexity…

种群与进化 · 定量生物学 2010-11-15 Byung Mook Weon , Jung Ho Je

The relative ageing is an important notion which is useful to measure how a system ages relative to another one. Among all existing stochastic orders, there are two important orders describing the relative ageing of two systems, namely,…

应用统计 · 统计学 2019-06-25 Nil Kamal Hazra , Neeraj Misra

The gradual accumulation of damage and dysregulation during the aging of living organisms can be quantified. Even so, the aging process is complex and has multiple interacting physiological scales -- from the molecular to cellular to whole…

定量方法 · 定量生物学 2021-05-06 Spencer Farrell , Garrett Stubbings , Kenneth Rockwood , Arnold Mitnitski , Andrew Rutenberg

Complex systems, in many different scientific sectors, show coarse-grain properties with simple growth laws with respect to fundamental microscopic algorithms. We propose a classification scheme of growth laws which includes human aging,…

生物物理 · 物理学 2012-07-17 P. Castorina , P. Blanchard

We investigate numerically the dynamics of three different spin models in the aging regime. Each of these models is meant to be representative of a distinct class of aging behavior: coarsening systems, discontinuous spin glasses, and…

无序系统与神经网络 · 物理学 2009-11-10 Andrea Montanari , Federico Ricci-Tersenghi

What is aging? Mechanistic answers to this question remain elusive despite decades of research. Here, we propose a mathematical model of cellular aging based on a model gene interaction network. Our network model is made of only non-aging…

分子网络 · 定量生物学 2023-09-12 Hong Qin

How self-organized networks develop, mature and degenerate is a key question for sociotechnical, cyberphysical and biological systems with potential applications from tackling violent extremism through to neurological diseases. So far, it…

物理与社会 · 物理学 2017-06-05 M. Zheng , Z. Cao , Y. Vorobyeva , P. Manrique , C. Song , N. F. Johnson

Aging is considered as the property of the elements of a system to be less prone to change states as they get older. We incorporate aging into the noisy voter model, a stochastic model in which the agents modify their binary state by means…

统计力学 · 物理学 2018-09-06 Oriol Artime , Antonio F. Peralta , Raúl Toral , José J. Ramasco , Maxi San Miguel

Models of many-species ecosystems, such as the Lotka-Volterra and replicator equations, suggest that these systems generically exhibit near-extinction processes, where population sizes go very close to zero for some time before rebounding,…

统计力学 · 物理学 2023-03-15 Thibaut Arnoulx de Pirey , Guy Bunin

Many real-world complex networks arise as a result of a competition between growth and rewiring processes. Usually the initial part of the evolution is dominated by growth while the later one rather by rewiring. The initial growth allows…

统计力学 · 物理学 2020-10-07 Zdzislaw Burda , Michalina Kotwica , Krzysztof Malarz

The network concept is increasingly used for the description of complex systems. Here we summarize key aspects of the evolvability and robustness of the hierarchical network-set of macromolecules, cells, organisms, and ecosystems. Listing…

分子网络 · 定量生物学 2010-10-05 Huba J. M. Kiss , Agoston Mihalik , Tibor Nanasi , Balint Ory , Zoltan Spiro , Csaba Soti , Peter Csermely

Aging, understood as the tendency to remain in a given state the longer the persistence time in that state, plays a crucial role in the dynamics of complex systems. In this paper, we explore the influence of aging on coevolution models,…

物理与社会 · 物理学 2025-10-27 Byungjoon Min , Maxi San Miguel

Ignoring the differences between countries, human reproductive and dispersal behaviors can be described by some standardized models, so whether there is a universal law of population growth hidden in the abundant and unstructured data from…

物理与社会 · 物理学 2024-02-08 Jiajun Ma , Qinghua Chen , Xiaosong Chen , Jingfang Fan , Xiaomeng Li , Yi Shi

There have been significant efforts devoted to solving the longevity risk given that a continuous growth in population ageing has become a severe issue for many developed countries over the past few decades. The Cairns-Blake-Dowd (CBD)…

应用统计 · 统计学 2024-12-30 Ka Kin Lam , Bo Wang

Existing theories for the evolution of aging and death treat senescence as a side-effect of strong selection for fertility. These theories are well-developed mathematically, but fit poorly with emerging experimental data. The data suggest…

种群与进化 · 定量生物学 2007-05-23 Josh Mitteldorf

Relative ageing describes how a system ages with respect to another one. The ageing faster orders are the ones which compare the relative ageings of two systems. Here, we study ageing faster orders in the hazard and the reversed hazard…

应用统计 · 统计学 2019-06-21 Nil Kamal Hazra , Neeraj Misra

Multiple species in the ecosystem are believed to compete cyclically for survival and thus maintain balance in nature. Stochasticity has also an inevitable role in this dynamics. Considering these attributes of nature, the stochastic…

种群与进化 · 定量生物学 2020-08-05 Sirshendu Bhattacharyya , Pritam Sinha , Rina De , Chittaranjan Hens

The chronological age used in demography describes the linear evolution of the life of a living being. The chronological age cannot give precise information about the exact developmental stage or aging processes an organism has reached. On…

偏微分方程分析 · 数学 2023-10-02 Jacques Demongeot , Pierre Magal
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