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Cancer survival prediction from multi-omics data remains challenging because prognostic signals are high-dimensional, heterogeneous, and distributed across interacting genes and pathways. We propose PathMoG, a pathway-centric modular graph…

机器学习 · 计算机科学 2026-04-28 Di Wang , Chupei Tang , Junxiao Kong , Jixiu Zhai , Moyu Tang , Tianchi Lu

Accurate survival prediction in oncology requires integrating diverse imaging modalities to capture the complex interplay of tumor biology. Traditional single-modality approaches often fail to leverage the complementary insights provided by…

计算机视觉与模式识别 · 计算机科学 2025-03-14 Ho Hin Lee , Alberto Santamaria-Pang , Jameson Merkov , Matthew Lungren , Ivan Tarapov

We introduce ProtoPathway, an interpretable-by-design multimodal framework for cancer survival prediction that unifies whole slide imaging and transcriptomics through encoders producing biologically grounded representations on both sides of…

计算机视觉与模式识别 · 计算机科学 2026-05-21 Amaya Gallagher-Syed , Costantino Pitzalis , Myles J. Lewis , Michael R. Barnes , Gregory Slabaugh

Accurate survival prediction is crucial for development of precision cancer medicine, creating the need for new sources of prognostic information. Recently, there has been significant interest in exploiting routinely collected clinical and…

机器学习 · 计算机科学 2021-03-23 Sejin Kim , Michal Kazmierski , Benjamin Haibe-Kains

Multimodal medical image fusion is a crucial task that combines complementary information from different imaging modalities into a unified representation, thereby enhancing diagnostic accuracy and treatment planning. While deep learning…

图像与视频处理 · 电气工程与系统科学 2024-11-19 Meng Zhou , Yuxuan Zhang , Xiaolan Xu , Jiayi Wang , Farzad Khalvati

Clinical decision-making in oncology involves multimodal data such as radiology scans, molecular profiling, histopathology slides, and clinical factors. Despite the importance of these modalities individually, no deep learning framework to…

计算机视觉与模式识别 · 计算机科学 2021-07-02 Nathaniel Braman , Jacob W. H. Gordon , Emery T. Goossens , Caleb Willis , Martin C. Stumpe , Jagadish Venkataraman

Accurate survival prediction in head and neck cancer (HNC) is essential for guiding clinical decision-making and optimizing treatment strategies. Traditional models, such as Cox proportional hazards, have been widely used but are limited in…

计算机视觉与模式识别 · 计算机科学 2024-10-30 Aiman Farooq , Utkarsh Sharma , Deepak Mishra

Survival analysis stands as a pivotal process in cancer treatment research, crucial for predicting patient survival rates accurately. Recent advancements in data collection techniques have paved the way for enhancing survival predictions by…

机器学习 · 计算机科学 2024-07-26 Linhao Qu , Dan Huang , Shaoting Zhang , Xiaosong Wang

The diagnosis and prognosis of cancer are typically based on multi-modal clinical data, including histology images and genomic data, due to the complex pathogenesis and high heterogeneity. Despite the advancements in digital pathology and…

定量方法 · 定量生物学 2024-04-15 Zeyu Zhang , Yuanshen Zhao , Jingxian Duan , Yaou Liu , Hairong Zheng , Dong Liang , Zhenyu Zhang , Zhi-Cheng Li

In recent years, multimodal medical data-based survival analysis has attracted much attention. However, real-world datasets often suffer from the problem of incomplete modality, where some patient modality information is missing due to…

计算机视觉与模式识别 · 计算机科学 2025-10-28 Yi Yin , Yuntao Shou , Zao Dai , Yun Peng , Tao Meng , Wei Ai , Keqin Li

We introduce a multimodal deep learning framework, Prescriptive Neural Networks (PNNs), that combines ideas from optimization and machine learning, and is, to the best of our knowledge, the first prescriptive method to handle multimodal…

机器学习 · 计算机科学 2025-01-27 Dimitris Bertsimas , Lisa Everest , Vasiliki Stoumpou

Genomics, especially multi-omics, has made precision medicine feasible. The completion and publicly accessible multi-omics resource with clinical outcome, such as The Cancer Genome Atlas (TCGA) is a great test bed for developing…

基因组学 · 定量生物学 2020-08-31 Lana X Garmire

Multimodal medical imaging plays a pivotal role in clinical diagnosis and research, as it combines information from various imaging modalities to provide a more comprehensive understanding of the underlying pathology. Recently, deep…

Multimodal survival prediction, a crucial yet challenging task, demands the integration of multimodal medical data (\eg Whole Slide Images (WSIs) and Genomic Profiles) to achieve accurate prognostic modeling. Given the inherent…

计算机视觉与模式识别 · 计算机科学 2026-05-21 Huayi Wang , Haochao Ying , Yuyang Xu , Qiyao Zheng , jun wang , Cheng Zhang , Ying Sun , Jian Wu

Technological advances in medical data collection, such as high-throughput genomic sequencing and digital high-resolution histopathology, have contributed to the rising requirement for multimodal biomedical modelling, specifically for…

机器学习 · 计算机科学 2024-10-29 Konstantin Hemker , Nikola Simidjievski , Mateja Jamnik

This study proposes a novel perspective on multimodal deep learning for biomedical signal classification, systematically analyzing how complementary feature domains impact model performance. While fusing multiple domains often presumes…

机器学习 · 计算机科学 2025-08-05 Timothy Oladunni , Alex Wong

Cancer prognosis and survival outcome predictions are crucial for therapeutic response estimation and for stratifying patients into various treatment groups. Medical domains concerned with cancer prognosis are abundant with multiple…

图像与视频处理 · 电气工程与系统科学 2024-02-29 Ruining Deng , Nazim Shaikh , Gareth Shannon , Yao Nie

Prognostic task is of great importance as it closely related to the survival analysis of patients, the optimization of treatment plans and the allocation of resources. The existing prognostic models have shown promising results on specific…

图像与视频处理 · 电气工程与系统科学 2025-01-14 Binyu Zhang , Shichao Li , Junpeng Jian , Zhu Meng , Limei Guo , Zhicheng Zhao

Multimodal sentiment analysis aims to extract and integrate semantic information collected from multiple modalities to recognize the expressed emotions and sentiment in multimodal data. This research area's major concern lies in developing…

人工智能 · 计算机科学 2021-08-31 Wei Han , Hui Chen , Alexander Gelbukh , Amir Zadeh , Louis-philippe Morency , Soujanya Poria

Purpose: Immunotherapies have revolutionized the landscape of cancer treatments. However, our understanding of response patterns in advanced cancers treated with immunotherapy remains limited. By leveraging routinely collected noninvasive…